5htp (5 htp) Hydroxytryptophan (hydroxy tryptophan)

Welcome To
SmartBodyz Nutrition
Your Online Source for Nutritional Supplements and Related Research

by Jarrow
Home Products
A-K
Products
L-Z
News / Studies Customer Service MX GuardDog Spam Blocker View Cart
Live Search
Buy anything from eBay!

5-HTP (hydroxy tryptophan) - Page 1
by James South of Vitamin Research News

The order page has moved -- click 5HTP to order.

The Serotonin Solution
This article first appeared in the March 1997 issue of Vitamin Research News reprinted by permission from Pat Whittington of Vitamin Research Products

Serotonin is one of the ten or so major brain neurotransmitters; there are perhaps 100 minor neurotransmitters.  Neurotransmitters are the biochemicals nerve cells use to "talk" to each other.  There are an estimated 10-100 billion neurons in the human brain and each neuron may connect to thousands of other neurons.  Yet, when these interconnecting neurons do not quite touch each other, there is a microscopic gap between them called the "synaptic gap."  As a burst of electric current travels down the length of a neuron, it releases a packet of neurotransmitter molecules which are stored at the edge of the synaptic gap.  These neurotransmitters then diffuse across the synaptic gap and "plug in" to the receptor sites of the next neuron, like keys fitting into locks.  When a sufficient number of molecules have "plugged in" to the corresponding receptors of the next neuron, this neuron then discharges a burst of electricity down its cell membrane surface, repeating the process with neurons to which it connects.

Thus, neurons use electricity to propagate a signal down the length of their own cell structure, but use chemical neurotransmitter molecules to signal other neurons. 

When there are inadequate numbers of neurotransmitters to activate other neurons, various brain circuits become under or overactive due to lack of communication between nerve cells.

Studies with humans and animals have shown that serotonin nerve circuits promote feelings of well being, calm, personal security, relaxation, confidence, and concentration.(15)  Serotonin neural circuits also help counterbalance the tendency of brain dopamine and noradrenalin (two other major neurotransmitters) to encourage over-arousal, fear, anger, tension, aggression, violence, obsessive-compulsive actions, overeating, anxiety and sleep disturbances.(15)  Unfortunately, neuroscience has also discovered that many people suffer from various degrees of brain serotonin deficiency, leading to a host of mental, emotional and behavioral problems.  To understand why brain serotonin deficiency is becoming ever more common in modern society, it is necessary to look at how the brain makes serotonin.

Serotonin Function
Serotonin (also called "5HT"), dopamine, and noradrenaline are the three main "monoamine" neurotransmitters.  They are each made from one specific amino acid.  Serotonin is made from the amino acid tryptophan while dopamine and noradrenaline are made from the amino acid tyrosine.  While other cells outside the brain such as blood platelets and some intestinal lining cells make and/or use serotonin, all serotonin used by brain cells must be made within the neurons.  Due to the blood-brain barrier, serotonin cannot be "imported" from outside the brain.  The blood-brain barrier serves as a protection device to prevent toxins from entering the brain, yet this protection comes at a price.  Even friendly molecules needed by the brain, such as amino acids, are limited in their access to the brain.  Nutrients are ferried through the blood-brain barrier by transport molecules, like passengers on a bus.  This creates a special bottleneck for serotonin.  Serotonin itself cannot pass through the blood-brain barrier, while its precursor tryptophan must share its transport "bus" with five other amino acids leucine, isoleucine, valine, tyrosine and phenylalanine.  In any normal diet, animal protein-based or vegetarian tryptophan is the least plentiful of all 20 food amino acids.  Thus, tryptophan is typically outnumbered as much as 7-9:1 in its competition to secure its transport through the blood-brain barrier into the brain.  Eating a high protein diet in an attempt to increase dietary tryptophan (a typical diet provides only 1-1.5 grams/day) only increases its competition even more.  Ironically, the only dietary strategy that increases brain tryptophan supply is to eat a high carbohydrate, low protein diet.  When large amounts of carbs are eaten, the body secretes large amounts of the hormone insulin to lower the ensuing high blood sugar.  Insulin also clears most of the five amino acids from the blood that compete with tryptophan for a ride to the brain.  Tryptophan then has the "bus" to itself, allowing plenty of tryptophan to reach the brain. (10)

This strategy is instinctively known and practiced by many Americans who eat large amounts of carbs such as candy, cake, pie, bread, chips, ice cream, etc.  They do this when they are feeling stressed, depressed, or anxious.  The increased brain serotonin this produces lowers arousal and anxiety which promotes a (temporary) sense of well-being and security.  This strategy comes at a price.  The same insulin which enhances brain serotonin also enhances the conversion of the fats, carbs, and aminos cleared from the blood into stored body fat!  Hence the carb addiction / overfat-serotonin connection. (10)

Tryptophan v. 5-HTP
In the 1970's, the American health food industry began providing an alternative method of getting more tryptophan to the brain with tryptophan supplements.  Some people found that 500 - 3000 mg of supplementary tryptophan daily provided sufficient support.  Yet, in 1989 the FDA removed tryptophan from the American health food market due to an ailment called eosinophilia myalgia (EMS) caused by a single batch of contaminated tryptophan from a single Japanese producer.  To this day, the FDA shows no signs of allowing tryptophan back on the market.  If the FDA were to re-approve tryptophan for general use, would it still be the best natural non-drug way to deal with the serotonin deficiency syndrome?  For several reasons, the answer is "No."

It is generally accepted that only about 1% or less of dietary/supplementary tryptophan ever enters the brain.  The rest is used to make various body proteins; some is converted into vitamin B-3 at a cost of 60 mg tryptophan to make one mg B-3; some is converted by other body cells into serotonin for their needs; and some may be broken down through the kynurenine pathway.  A liver enzyme, tryptophan pyrrolase, converts tryptophan into kynurenine, which may then be converted to hydroxykynurenine (3-OH-K), xanthurenic acid (XA), and hydroxyanthranilic acid (3-OH-AA) for urinary excretion.  Unfortunately, 3-OH-K, XA and 3-OH-AA are all known to cause liver damage and bladder cancer.(16)  It may not be pure chance or coincidence that nature has arranged tryptophan to be the least plentiful amino in our diets.  Furthermore, there are at least two known factors which significantly increase liver pyrrolase activity, dramatically enhancing production of these toxic metabolites.  The first is the stress hormone cortisol.(13)   Cortisol, produced by the adrenal glands, is the "state-of-siege" stress hormone.  It is released in response to unremitting stress which we can neither fight nor flee.  Cortisol is known to be elevated frequently in the very conditions, such as depression, insomnia and obesity(13), for which tryptophan / serotonin might be useful.  Thus, taking tryptophan supplements while under elevated cortisol-stress conditions might supply little extra to the brain for serotonin synthesis, yet dramatically raise toxic 3-OH-K, XA and 3-OH-AA levels.

The second factor known to increase liver pyrrolase activity is increased intake of tryptophan.  The kynurenine pathway is the major degradation pathway for tryptophan in the human body, and higher tryptophan intake automatically induces higher pyrrolase activity.(13)  This explains why studies using tryptophan as an antidepressant frequently find moderate doses more effective than high doses, and why van Praag noted in 1981 that "L-tryptophan was found to be effective in [only] five of the ten double-blind comparative studies."(5)

Fortunately, a safe alternative to both tryptophan and drugs (such as Prozac) is now available in the U.S. without a prescription.  This substance is L-5-Hydroxytryptophan (5-HTP).  5-HTP is not produced by bacterial fermentation (as was the tainted tryptophan) nor chemical synthesis but is extracted from the seeds of the Griffonia plant.

Recommended Dosage
The recommended dose of 5HTP for most people is 50-100 mg, three times a day, 20 minutes before meals.

Click here to read more from Dr. Michael T. Murray, Author of  5-HTP: The Natural Way to Boost Serotonin.

Click here for 6 steps to healthy sleep by Dr. David Williams.

More Information | Conclusion and References

 Order:   5HTP | Melatonin | Valerian and Herbal Sleep Formula | Vitamin B12 | GABA

Pay it Forward - Give You and Your Loved Ones the Gift of Health!
Sale - In addition to your 25% off, you get another 10% automatic volume discount at checkout on orders of $25 or more ... all items apply (including special sale items).  SECURE SHOPPING CART CREDIT CARD PURCHASES ONLY.  Call-ins do not receive this special discount.

 

Enjoy the benefits of our flat rate shipping and handling!  You receive the same great service for the same shipping price whether you order one item or one hundred!

$5.97 - Within USA only - US Post Office  5-9 business days.

$29.77 - To Canada only (see warning information here) 5-9 business days to customs check point (the only way we ship - US Post Office).

$39.77 - Outside USA only
(see warning here) 7-10 business days to your country's customs check point (the only way we ship - US Post Office).

Save 8.25% on all purchases - Texans and everyone!

It's all tax free!  You will be able to review all charges before they are charged to you.

At checkout (after you click the Add button on any of the order pages), the billing address you enter must match the address where you receive your credit card (security effects).  The shipping address you enter does not have to match.

All orders placed by Noon Central Standard Time (CST) are shipped the same day.  PO Boxes Okay.

Payment by credit card and PayPal is immediate.  Payment by check adds a few more business days -- as soon as funds clear.

We do not sell the information you give us to anyone.


Protecting Your Personal Information
:
We pledge a safe and worry-free shopping experience using the industry standard for Internet security, 128-bit Secure Sockets Layer (SSL) encryption (see an online payments diagram).  SSL scrambles your personal and credit card information as it travels the Internet during the checkout process.  We utilize the Authorize.Net payment gateway.  Your credit card information is encrypted and sent to an Authorize.Net transaction server.  This server sends the data through the network to the card's bank, using a secure, proprietary connection.  When complete, you will receive an approval or decline response.  At no point is your credit card information stored on our server.

For additional information regarding the privacy of your sensitive cardholder data, please read the Authorize.Net Privacy Policy.

SmartBodyz Nutrition Home Page
1000 West 10th, Suite 218
Fort Worth, Texas 76102
Local Telephone: 817-335-1982
Email: DG[at]SmartBodyz.com - replace [at] with @
(helps prevent spam)
Copyright 1996-2016, SmartBodyz Nutrition -- all rights reserved.

Credit Card Processing

Credit Card Processing

You can shop here with safety and confidence.  We have partnered with Authorize.Net, a leading payment gateway since 1996, to offer safe and secure credit card transactions.  We also offer PayPal Checkout.

Order Anything
Amazon Shopping

The information and statements made throughout this web site have not been endorsed/evaluated by the Food and Drug Administration or any other governmental authority, unless otherwise specifically noted.  We do not offer products or services for the benefits or purpose of diagnosis, prescription for, treatment of, or claims to prevent, mitigate or cure any viral or disease condition or be free from side effects.  Please, seek the advice of a competent medical professional about anything you read on our site.

BlogBlogLinks | Testimonials | Privacy | RSS Feed