Adipocytes, Adipose Obesity, Belly Fat Buring Cells, Adipocytes - Page 1

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Shed Pounds by Inhibiting Cellular Fat Storage - Page 1
By Kirk Stokel - Reprinted by permission from Bill Faloon of The Life Extension Foundation

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Health authorities are warning about the devastating consequences of obesity, yet doctors remain in the dark about what causes people to accumulate so many fat pounds as they age.

Through a series of well-designed studies, scientists investigating certain plant extracts found they can block fat storage at the cellular level.

In a significant scientific advance, a potent new weapon has been identified to help safely induce weight loss.

This article describes how a novel dual plant extract favorably modulates six pathways that fat cells use to trigger weight gain.

When tested on humans in a placebo-controlled study, those taking this dual plant extract lost 4.05 inches of abdominal fat and dropped 11.4 pounds after eight weeks with weight loss observed as early as 14 days.1

Cells that store fat are called adipocytes.  They are deposited throughout our bodies.2,3

As we age, adipocytes tend to expand and congregate in areas that are cosmetically unsightly and detrimental to our health.

Cells that store fat are called adipocytes.  They are deposited throughout our bodies.2,3

As we age, adipocytes tend to expand and congregate in areas that are cosmetically unsightly and detrimental to our health.

Of greatest concern are the adipocytes that deposit deep in our abdomens.  This visceral fat represents more than fat stored on our waistlines. Visceral fat is chemically active tissue that churns out a torrent of pro-inflammatory cytokines.4

Those with bulging belly fat suffer constant bombardment from toxic cytokines that trigger the metabolic syndrome and its deadly consequences.5,6

This widespread problem led scientists to seek out plant extracts that specifically interfere with adipocyte fat storage in our abdominal anatomy.

Sphaeranthus Indicus

Sphaeranthus Indicus

How Unwanted Fat Storage Occurs
Excess calories transform to fat deposits in adipocytes7 through a multi-step process known as adipogenesis.

When fewer calories are consumed, fat is released from adipocytes to meet the bodys energy needs.8,9  This is known as lipolysis.

A dual plant extract has been studied based on its ability to simultaneously inhibit adipogenesis (fat storage) and enhance lipolysis (fat breakdown and release).

Mangosteen Fruit

Mangosteen Fruit

Like any other cell, adipocytes develop from undifferentiated stem cells.  Premature, developing fat cells are called pre-adipocytes.  When you ingest more calories than your body needs, young pre-adipocytes respond by maturing into adult adipocytes.7,10-12

Adult adipocytes take up excess fatty acids from your bloodstream and begin expanding.  It is this process of fatty acid uptake and adipocyte expansion that ultimately results in obesity and its pathologic consequences.  Every excess calorie contributes to the maturation and growth of fat cells in this way.  Past a certain point, adipocytes distend and become bloated, much in the same way your belly does.

Not all adipocytes are the same.  While fat cells distribute throughout your body, those that store in your abdomen -- producing so-called visceral fat or belly fat -- are more than just storage containers.

Belly fat cells are chemically active.  They form fatty tissue capable of releasing detrimental pro-inflammatory cytokines.4

In obese individuals, the mass of excess visceral fat deposits generates a pro-inflammatory flood of cytokines.  This cytokine release then incites a cascade of harmful effects that, if left unchecked, contributes to the onset of multiple degenerative diseases.5,6

So unwanted body fat storage happens when pre-adipocyte stem cells mature in order to store excess dietary fat (adipogenesis) while the ability to break down stored fat (lipolysis) diminishes.

What You Need to Know:  Inhibiting Cellular Fat Storage
  • An obesity epidemic continues to rage in this country, with more than two-thirds of the American population overweight or obese,
  • Conventional medicine has yet to offer any safe, long-term, practical solution,
  • Cutting-edge researchers continue to identify novel natural weight loss -- inducing agents,
  • Among the most recent is a dual plant extract containing extracts of the flower S. indicus and the mangosteen fruit, both native to Asia,
  • When combined, the resulting dual extract blend was found to favorably influence six distinct biomolecular pathways by which fat cells trigger weight gain.  In placebo-controlled clinical trials involving obese subjects, this dual extract safely induced total weight loss of 11.4 pounds, a decline of 2.05 in body mass index (BMI), and a reduction of 4.05 inches in harmful visceral fat after just eight weeks.1

Combating Surplus Body Fat Storage
Searching for natural interventions that would effectively inhibit fat accumulation (adipogenesis) and enhance fat burning (lipolysis), scientists evaluated more than a thousand plants for evidence that would meet this criteria.13

Two plants whose extracts demonstrated significant biological effects were:

  1. Sphaeranthus indicus flower (S. indicus)13
  2. Mangosteen fruit (Garcinia mangostana).13
Control adipocyte cells not treated with S. indicus display lipid accumulation
Control adipocyte cells not treated with S. indicus display lipid accumulation.
Adipocyte cells treated with S. indicus inhibited fat accumulation
Adipocyte cells treated with S. indicus inhibited fat accumulation.

In the laboratory, S. indicus and mangosteen extracts powerfully impeded adipogenesis.

When cells were treated with S. indicus alone, fat storage was inhibited by as much as 65%, compared with control cells.  Photographs (below) show a markedly visible difference between the two cell groups.  The control cells show a bloated, foamy appearance, bulging with fat droplets, compared to the smaller, more naturally contoured cells treated with the S. indicus extract.13

Each of these extracts also enhanced lipolysis (or fat burning), by as much as 56% compared to control cells.13

Having identified these unifying properties in the two extracts, the researchers set out to determine if they would exhibit enhanced effects when used in combination.

They found that the S. indicus and mangosteen extracts favorably modulate the activity of six genomic pathways involved in fat cell formation and breakdown.13

Remarkably, these extracts reduced gene expression that promotes adipogenesis while favorably influencing a gene involved in desirable lipolysis.

The box on this page shows how these plant extracts, used alone and in combination, positively modulated the markers involved in unwanted cellular fat accumulation by inhibiting adipogenesis and promoting lipolysis.

Given these observations, researchers recognized that this novel blend of plant extracts could result in significant weight loss via three distinct mechanisms:

  1. Preventing young fat cells (pre-adipocytes) from developing into mature fat cells (adipocytes),
  2. Reducing the amount of fatty acids adipocytes could absorb,
  3. Speeding breakdown of bloated adipocytes existing fat stores.

The next step was to determine if these plant extracts would induce weight loss in experimental animals and -- more importantly -- obese humans.

Preventing Obesity in Rodents
When young adult rats are fed a high-fat diet they rapidly gain weight -- just as humans often do.

Dual Plant Extract Burning Fat Cells To investigate the effects of the plant extracts that worked in cell studies, scientists fed a group of young adult rats a high-fat diet.  Half the rats received the dual plant extract while the other half served as the control group.13

At the end of eight weeks, the control group rapidly gained weight.  The rats fed a high-fat diet and given the dual plant extract, on the other hand, reduced body weight gain by an impressive 700%.13

This is not surprising considering these same plant extracts blocked fat accumulation by 48.5% and 65.9% in the cellular model.13

This study demonstrated that these plant extracts decrease diet-induced obesity in young adult rats.  The real challenge, however, is whether these same plant extracts are effective in humans who are already obese.

Anti-Adipocyte Formula with adipocytes - Ingredients/Dose | Page 2 | References

 Pricing Information:   Anti-Adipocyte Formula | Saffron Extract w/Satiereal (Crocus Sativus L.) | Fastin | San-Hoodia |
Forskolin (Coleus Forskohlii) [Obesity/Weight Loss] | Konjac Fiber Root Extract (LuraLean), White Kidney Bean, Irvingia |
Hydroxycut | CLA w/Guarana | 5-HTP

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