African Mango (Irvingia Gabonensis) - Weight-Loss, Side-Effects / Dose

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African Mango (Irvingia Gabonensis) - Weight-Loss, Side-Effects / Dose
This is the authentic irvingia gabonensis, (African mango extract).

The Optimized Irvingia with Phase 3 Calorie Control Complex with African mango formulation provides a combination of natural compounds that aid in weight loss while combating age-related fat accumulation via the following eight distinct mechanisms:

1.  Delaying digestion and absorption of sucrose,
2.  Enhancing resting energy expenditure at the cellular level,
3.  Slowing the absorption of dietary fat from the intestines while aiding weight loss,
4.  Moderating alpha-amylase enzyme activity to reduce the absorption of carbohydrates into the bloodstream,
5.  Reducing alpha-glucosidase enzyme activity to further slow the absorption of starches and sugars into the bloodstream,
6.  Supporting leptin sensitivity to stimulate lipolysis,
7.  Supporting youthful levels of adiponectin to help maintain healthy insulin sensitivity,
8.  Moderating glycerol-3-phosphate dehydrogenase enzyme activity and its positive side effects to reduce the amount of ingested starches that are converted to triglycerides and stored as fat.

Phase 3 Sucrase Modulator
A recent study in the journal Science concluded that in primates a calorie-restricted diet, leading to weight loss, can delay disease onset and age-related mortality.28  While Life Extension readers understand the positive side effects of calorie restriction, that doesn't make it any easier to cut back on one of the major calorie culprits in the American diet:  Refined sugar.

Sucrase is an enzyme that breaks down sucrose in the digestive tract for absorption into the bloodstream.  Phase 3 is a patented compound that functions as a beneficial sucrase modulator.  It contains L-Arabinose, a natural substance found in plants that reduces the number of absorbed calories from sugar.  Phase 3 can help support healthy insulin metabolism and sugar levels in the bloodstream while assisting with weight loss.  Phase3 is just one ingredient in Optimized Irvingia.

Green Tea Phytosome Cellular Energy Enhancer
The positive side effects of green tea extracts to inhibit the breakdown and absorption of dietary fat has been the subject of research studies across the globe.  Mounting scientific research has documented the metabolic effects of green tea polyphenols.  A proprietary phytosome complex has shown an ability to increase the absorption of green tea polyphenols into the bloodstream better than conventional tea extracts resulting in peak plasma levels of the critical green tea polyphenol epigallocatechin-3-gallate which can lead to weight loss.29

Participants in a human clinical trial showed an average weight loss of 30 pounds and a 10% reduction in waist circumference in 90 days when 300 mg/day of this new green tea phytosome was taken in conjunction with a reduced-calorie diet.29  The placebo group that followed the same reduced-calorie diet lost only 9.9 pounds and only 5% of their waist size.  Optimized Irvingia contains the exact same green tea phytosome as was used in this study, thus linear positive side effects were not obtained between the 2 groups.

The Alpha-Amylase Enzyme
Aging reduces our ability to utilize the carbohydrates (and fats) that constitute what most would consider part of a healthy diet.  The result is that as we grow older, our bloodstreams become chronically bloated with glucose and triglycerides in direct contrast to the youthful metabolic profile we have in our younger years making weight loss more difficult.  Emerging scientific research suggests that the negative side effects associated with the alpha-amylase enzyme plays an undesirable role in the digestion of dietary carbohydrates and subsequent absorption of calories from starch and sugar.  A natural bean extract (Phaseolus vulgaris) moderates alpha-amylase activity.  In a human trial in which all overweight participants were placed on a 2,000-2,200 calorie, carbohydrate-rich diet, those taking Phaseolus vulgaris lost 6.5 pounds and 1.2 inches in waist size in only 30 days compared with 0.8 pounds and 0.2 inches in the placebo group.30  Optimized Irvingia contains the identical Phaseolus vulgaris used in this study.

The Alpha-Glucosidase Enzyme
Another intestinal enzyme that displays positive side effects is alpha-glucosidase which enables carbohydrate absorption.  A patented seaweed extract (InSea2) has demonstrated the ability to help maintain healthy levels of both alpha-glucosidase and alpha-amylase.  When given to laboratory animals, this seaweed extract reduced after-meal (postprandial) glucose elevations by up to 90% compared with non-supplemented animals.31

Remember, young healthy individuals rapidly convert ingested fats and sugars into energy making weight loss easier.  Age-related changes decrease our metabolic capacity to efficiently utilize dietary fats and sugars and the side effects associated with them.  It is thus paramount for aging people to reduce their absorption of excess calories.  By taking nutrients before each meal that reduce the activity of carbohydrate and fat digesting enzymes, the calorie burden is significantly reduced.  Optimized Irvingia provides the same InSea2 extract as used in laboratory studies.

Leptin Sensitivity
Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough.  Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes via the process of lipolysis.  Heavy individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds.

An extract from a West African food called Irvingia gabonensis (African mango extract) has been shown to help support leptin sensitivity in overweight people.  In a recently published study, Irvingia demonstrated beneficial side effects upon leptin blood levels, followed by weight loss and inches off the waistline.32  In addition to supporting healthy leptin sensitivity, Irvingia has demonstrated the following beneficial effects on key aspects of metabolism:

  • Glycerol-3-phosphate dehydrogenase is an enzyme involved in the complex biochemical process that converts ingested starch and sugar calories to stored body fat.  African mango Irvingia has been shown in studies involving fat cells to reduce the activity of glycerol-3-phosphate dehydrogenase,33 which may help reduce the impact of starch and sugar calories on body fat.
  • Scientific research on fat cells suggests that African mango Irvingia has alpha-amylase-inhibiting properties34 (like InSea2 and Phaseolus vulgaris) which can help support a slowing of the rate of carbohydrate absorption from the intestines and a reduction of the caloric impact of starchy and sugary foods.35
  • Adiponectin is a hormone involved in helping to maintain insulin sensitivity on the membranes of energy-producing cells.  Big fat cells produce less adiponectin, and overweight people need to be especially concerned about maintaining healthy levels of adiponectin to support insulin sensitivity and metabolic fitness.  Scientific data suggests that African mango Irvingia helps support healthy adiponectin levels.33

Optimized Irvingia with Phase 3 Calorie Control Complex is indeed an innovative multi-modal approach to weight loss with an additional benefit. By helping to slow the absorption of starches and sugars, it reduces their caloric impact.  And, according to a recent mammalian study, those following a calorie-restricted diet were shown to significantly reduce the risk of mortality from age-related causes and its side effects.28  This suggests that regular supplementation with this African mango Irvingia formulation may help provide anti-aging benefits similar to those found in this recent study.

This supplement should be taken in conjunction with a healthy diet and regular exercise program.  Results may vary.


Supplement Facts:  Serving Size - 2 Caps.  Servings/Container - 60.

  Amount / Serving

Iodine - (typical value naturally occurring from Ascophyllum nodosum and Fucus vesiculosus)

37.5 mcg

Chromium (as Chromium GlycoProtein Matrix) 100 mcg
Integra-Lean Irvingia gabonensis (African Mango) proprietary extract (seed) 150 mg
Calorie Control Complex providing:

InSea2 [proprietary composition of demineralized polyphenols from brown seaweeds Kelp (Ascophyllum nodosum) and Bladderwrack (Fucus vesiculosus)]
125 mg
TeaSlender Green Tea Phytosome Green Tea (Camellia sinensis) Phytosome decaffeinated extract (leaf) containing standardized green tea extract bound to phosphatidylcholine (from lecithin) 150 mg
Phase 2 Phaseolus vulgaris white kidney (bean) extract 445 mg
Phase 3 Sucrase Inhibitor L-Arabinose and Chromium GlycoProtein Matrix (supplying 475 mg L-arabinose and 100 mcg chromium in a food bound state) 550 mg

Other ingredients:  Vegetable cellulose (capsule), stearic acid, silica, vegetable stearate, maltodextrin.  Contains soybeans and tree nuts.  Contains yeast and corn.  This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), wheat, gluten or rice. Contains NO artificial sweeteners, flavors, colors, or preservatives. Integra-Lean Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. InSea2 is a trademark of innoVactiv Phase 2 and Phase 3 are used under license.

Dosage and Use:
  Dosage and Use Take two capsules twice daily 15 minutes before meals.  Best if taken before meals containing carbohydrates or starches, or as recommended by a healthcare practitioner.

Caution and Side Effects:  Because this product may lower blood glucose, consult your healthcare provider before taking this product if you are taking blood glucose lowering medication.  Take at least two hours apart from medications.  Because this product may lower blood glucose, consult your healthcare provider before taking this product if you are taking blood glucose lowering medication.  Do not take fiber supplements with oil-based products such as CLA, flax seed oil, krill, fish oil, GLA (borage), or CoQ10.  Do not use if abdominal pain, nausea, or vomiting is present.

Note:  Optimized Irvingia with Phase 3 Calorie Control Complex w/African Mango (Irvingia Gabonensis) is designed to target several critical factors involved in age-related weight gain.  Those who ingest more calories than what their body has the metabolic capacity to utilize, will not see results.  This is because some people are ingesting so many excess calories that no matter how much their metabolic rate is increased, or how much improvement occurs in their post-meal blood sugar and serum triglyceride levels, or how much youthful insulin sensitivity and other body fat-regulating systems are restored, they are overwhelming the metabolic capacity to utilize these calories.  This will result in excess calories being stored in adipocytes.  One cannot consume limitless calories and expect to shed fat pounds by taking drugs, nutrients, and/or hormones that demonstrate weight-loss effects in clinical studies.

Warnings Information:

  • Keep Optimized Irvingia with Phase 3 Calorie Control Complex w/African Mango (Irvingia Gabonensis) out of reach of children,
  • Do not exceed recommended dose,
  • If you have a bad reaction or unwanted side effects, discontinue use immediately,
  • When using Optimized Irvingia with Phase 3 Calorie Control Complex w/African Mango (Irvingia Gabonensis), please inform your physician concerning weight loss issues.

 Pricing Information:  Optimized Irvingia with Phase 3 Calorie Control Complex w/African Mango (Irvingia Gabonensis) |
Forskolin (Coleus Forskohlii) [Obesity/Weight Loss] | Fastin | San-Hoodia | Original |
Hydroxycut | CLA w/Guarana | 5-HTP

28. Science. 2009 Jul 10;325(5937):201-4.
29. ntegr Nutr. 2008;11(2):1-14.
30. Int J Med Sci. 2007;4:45-52.
31. index.php?option=com_content&task=view&id=18&Itemid=
32. Lipids Health Dis. 2009 Mar 2;8:7.
33. Lipids Health Dis. 2008 Nov 13;7:44.
34. Ann Nutr Metab. 1993;37(1):14-23.
35. Lipids Health Dis. 2008 Mar 31;7:12.

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