CLA (Conjugated Linoleic Acid - Safflower Oil) With/Without Guarana - Body Fat Information

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Conjugated Linoleic Acid (CLA - Safflower Oil) With or Without Guarana - Drop Body Fat

Conjugated linoleic acid (CLA - from safflower oil) refers to a group of positional and geometric isomers of linoleic acid, which are found primarily in meat and dairy products.  CLA has been shown in a number of studies to have a wide variety of benefits with regards to the immune system, cardiovascular protection, blood sugar maintenance, lipid profiles and body composition.93-107

In studies that support the use of CLA in a weight loss program, the amount of CLA (from safflower oil) used varies from 1.7 to 12 grams per day. Those studies included:

  • A study that showed a dose of 3.4 g CLA per day for 12 weeks seems to be sufficient to reduce body fat mass (BFM) significantly in overweight and obese humans.101
  • Another study on human subjects that showed 3.2 g per day of CLA increased lean body mass over a 12 week period.102
  • A six month study on healthy or overweight adults showed CLA (from safflower oil) decreased body fat mass in specific regions of the body for all participants.104

  • Another six-month study on healthy overweight people showed that supplementation with CLA (from safflower oil) prevented weight gain during the holiday season.106  Modest loss in fat mass has been shown using 3.2 grams per day of CLA.107

Sesame lignans have been shown to stimulate fatty acid oxidation in the liver, and help stimulate lipolysis (fat breakdown).108,109

In a study presented at the Experimental Biology 2002 meeting, CLA (from safflower oil) alone was shown to cause a substantial decrease in fat mass, and for those who received CLA plus guarana, both adipocyte (fat cell) size and number were decreased by 50%.  As an added benefit, sesame lignans have been shown to further increase fat loss by stimulating fatty acid oxidation in the liver.  As with any fatty acid, CLA can be oxidized by free radicals once it has been ingested.  Sesame lignans help prevent the oxidation of CLA, providing health benefits without negative impact.

Guarana, an herb that contains a form of caffeine, called guaranine, is 2.5 times stronger than caffeine, but does not cause a caffeine rush in most people.  That's because guarana slowly releases into the system over as much as six hours.  One can thus conclude that the combination of guarana and CLA (from safflower oil) could have a profound effect.

The primary dietary sources of CLA are beef and milk.  Americans are eating less red meat and drinking less whole milk in order to reduce their dietary intake of saturated fat.

People often drink non-fat milk, but it's the fat content of the milk that contains CLA.  Since skim milk contains virtually no CLA, those seeking to lose weight who use skim milk are depriving themselves of a potential source of this nutrient.  In 1963, the CLA percentage in milk was as high as 2.81%.  By 1992, the percentage of CLA in dairy products seldom exceeded 1%.  The reason for the sharp reduction in milk CLA was because of changing feeding patterns.  Cows that eat natural grass produce lots of CLA.  Today's "efficient" feeding methods rely far less on natural grass.  Grass-fed Australian cows have 3 to 4 times as much CLA in their meat as American cows.  Grass-fed animals have 2 to 3 times more omega-3 fatty acids than grain-fed animals.  Most Americans thus have inadequate amounts of CLA in their diet, and this CLA deficit may be at least partially responsible for the epidemic of overweight people of all ages that now exists.  Thus, Life Extension created CLA from safflower oil.

The effects of Alpine milk may be the healthiest of all.  Milk from one hundred percent grass-fed cows is healthier than milk from grain-fed cows because it contains more of a number of key nutrients, including omega-3 fatty acids, beta-carotene (included in Life Extension Mix), and conjugated linoleic acid or CLA.  Why?  Plants growing in higher altitudes have more omega-3 fatty acids, fats which solidify at lower temperatures than other fats and therefore act as a form of anti-freeze.  The cows eat this enriched pasture and pass the nutrients on to their milk.

Supplement to be taken in conjunction with a healthy diet and regular exercise program.  Benefits and weight loss may vary.

Warnings Information:

  • Keep CLA (conjugated linoleic acid with safflower oil and sesame lignans) supplements with or without guarana out of reach of children,
  • Do not exceed recommended dose,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using, please inform your physician,
  • If you are pregnant or breastfeeding, consult your health care professional before using CLA (conjugated linoleic acid with safflower oil and sesame lignans) supplements.

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References:
93. Med Sci Sports Exerc. 2004 May;36(5):814-20.
94. Eur J Clin Nutr. 2003 Apr;57(4):595-603.
95. Br J Nutr. 2002 Sep;88(3):243-51.
96. Lipids. 2001 Mar;36(3):221-7.
97. Am J Clin Nutr. 2004 Jun;79(6):1118-25.
98. J Int Med Res. 2001 Sep-Oct;29(5):392-6.
99. Int J Obes Relat Metab Disord. 2001 Aug;25(8):1129-35.
100. Lipids. 2001 Aug;36(8):773-81.
101. J Nutr. 2000 Dec;130(12):2943-8.
102. J Nutr. 2007 May;137(5):1188-93.
103. Br J Nutr. 2007 May;97(5):1001-11.
104. Br J Nutr. 2007 Mar;97(3):550-60.
105. Br J Nutr. 2007 Feb;97(2):273-80.
106. Int J Obes (Lond). 2007 Mar;31(3):481-7.
107. Am J Clin Nutr. 2007 May;85(5):1203-11.
108. Metabolism. 1999 Oct;48(10):1303-13.
109. Biosci Biotechnol Biochem. 2001 Nov;65(11):2535-41.

 

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