CoQ10 May Protect Against Ischemic Heart Disease and Free Radicals

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CoQ10 May Protect Against Ischemic Heart Disease

NewsRx.com

06-12-08

"Ischemia, reperfusion, and free radical generation have been recently implicated in progressive bladder dysfunction.  Coenzyme Q10 (CoQ10) is a pro-vitamin like substance that appears to be efficient for neurodegenerative disorders and ischemic heart disease," scientists writing in the journal Molecular and Cellular Biochemistry, report (see also Ischemia).

"Our goal was to investigate the potential protective effect of CoQ10 in a rabbit model of in vivo bilateral ischemia and ischemia/reperfusion (I/R).  Material and Methods Six groups of four male New Zealand White rabbits each were treated with CoQ10 (3 mg/kg body weight/day-dissolved in peanut oil) (groups 1-3) or vehicle (peanut oil) (groups 4-6).  Groups 1 and 4 (ischemia-alone groups) had clamped bilateral vesical arteries for 2 h; in groups 2 and 5 (I/R groups), bilateral ischemia was similarly induced and the rabbits were allowed to recover for 2 weeks.

Groups 3 and 6 were controls (shams) and were exposed to sham surgery.  The effects on contractile responses to various stimulations and biochemical studies such as citrate synthase (CS), choline acetyltransferase (ChAT), superoxide dismutase (SOD), and catalase (CAT) were evaluated.  The protein peroxidation indicator, carbonyl group, and nitrotyrosine contents were analyzed by Western Blotting.  Ischemia resulted in significant reductions in the contractile responses to all forms of stimulation in vehicle-fed rabbits, whereas there were no reductions in CoQ10-treated rabbits.  Contractile responses were significantly reduced in vehicle-treated I/R groups, but significantly improved in CoQ10-treated rabbits.  Protein carbonylation and nitration increased significantly in ischemia-alone and I/R bladders; CoQ10 treatment significantly attenuated protein carbonylation and nitration.  CoQ10 up-regulated SOD and CAT activities in control animals; the few differences in CoQ10-treated animal in SOD and CAT after ischemia and in general increase CAT activities following I/R.  CoQ10 supplementation provides bladder protection against I/R injury," wrote Y.S. Juan and colleagues.

The researchers concluded:  "This protection effect improves mitochondrial function during I/R by repleting mitochondrial CoQ10 stores and potentiating their antioxidant properties."

Juan and colleagues published their study in Molecular and Cellular Biochemistry (Coenzyme Q10 protect against ischemia/reperfusion induced biochemical and functional changes in rabbit urinary bladder.  Molecular and Cellular Biochemistry, 2008;311(1-2):73-80).

Additional information can be obtained by contacting R.M. Levin, Albany College Pharmacy, 106 New Scotland Avenue, Albany, NY 12208, USA.

The publisher of the journal Molecular and Cellular Biochemistry can be contacted at:  Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands.

Keywords:  United States, Albany, Biochemical, Blood Transfusion, Cellular Biochemistry, Choline, Dietary Supplement, Heart Disease, Ischemia, Medical Device, Mental Health, Micronutrient, Myocardial Ischemia, Neurodegenerative, Perfusion, Reperfusion, Surgery, Transfusion Medicine.

This article was prepared by Heart Disease Weekly editors from staff and other reports. Copyright 2008, Heart Disease Weekly.

To see more of NewsRx.com, go to http://www.newsrx.com.

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