CoQ10 May Protect Against Ischemic Heart Disease and Free Radicals

Welcome To
SmartBodyz Nutrition
Your Online Source for Nutritional Supplements and Related Research

CoQ10 - Ischemic Heart Disease & Free Radicals
Home Products
Amazon Shopping Terms and Conditions MX GuardDog Spam Blocker View Cart
Live Search
Buy anything from eBay!

CoQ10 May Protect Against Ischemic Heart Disease


"Ischemia, reperfusion, and free radical generation have been recently implicated in progressive bladder dysfunction.  Coenzyme Q10 (CoQ10) is a pro-vitamin like substance that appears to be efficient for neurodegenerative disorders and ischemic heart disease," scientists writing in the journal Molecular and Cellular Biochemistry, report (see also Ischemia).

"Our goal was to investigate the potential protective effect of CoQ10 in a rabbit model of in vivo bilateral ischemia and ischemia/reperfusion (I/R).  Material and Methods Six groups of four male New Zealand White rabbits each were treated with CoQ10 (3 mg/kg body weight/day-dissolved in peanut oil) (groups 1-3) or vehicle (peanut oil) (groups 4-6).  Groups 1 and 4 (ischemia-alone groups) had clamped bilateral vesical arteries for 2 h; in groups 2 and 5 (I/R groups), bilateral ischemia was similarly induced and the rabbits were allowed to recover for 2 weeks.

Groups 3 and 6 were controls (shams) and were exposed to sham surgery.  The effects on contractile responses to various stimulations and biochemical studies such as citrate synthase (CS), choline acetyltransferase (ChAT), superoxide dismutase (SOD), and catalase (CAT) were evaluated.  The protein peroxidation indicator, carbonyl group, and nitrotyrosine contents were analyzed by Western Blotting.  Ischemia resulted in significant reductions in the contractile responses to all forms of stimulation in vehicle-fed rabbits, whereas there were no reductions in CoQ10-treated rabbits.  Contractile responses were significantly reduced in vehicle-treated I/R groups, but significantly improved in CoQ10-treated rabbits.  Protein carbonylation and nitration increased significantly in ischemia-alone and I/R bladders; CoQ10 treatment significantly attenuated protein carbonylation and nitration.  CoQ10 up-regulated SOD and CAT activities in control animals; the few differences in CoQ10-treated animal in SOD and CAT after ischemia and in general increase CAT activities following I/R.  CoQ10 supplementation provides bladder protection against I/R injury," wrote Y.S. Juan and colleagues.

The researchers concluded:  "This protection effect improves mitochondrial function during I/R by repleting mitochondrial CoQ10 stores and potentiating their antioxidant properties."

Juan and colleagues published their study in Molecular and Cellular Biochemistry (Coenzyme Q10 protect against ischemia/reperfusion induced biochemical and functional changes in rabbit urinary bladder.  Molecular and Cellular Biochemistry, 2008;311(1-2):73-80).

Additional information can be obtained by contacting R.M. Levin, Albany College Pharmacy, 106 New Scotland Avenue, Albany, NY 12208, USA.

The publisher of the journal Molecular and Cellular Biochemistry can be contacted at:  Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands.

Keywords:  United States, Albany, Biochemical, Blood Transfusion, Cellular Biochemistry, Choline, Dietary Supplement, Heart Disease, Ischemia, Medical Device, Mental Health, Micronutrient, Myocardial Ischemia, Neurodegenerative, Perfusion, Reperfusion, Surgery, Transfusion Medicine.

This article was prepared by Heart Disease Weekly editors from staff and other reports. Copyright 2008, Heart Disease Weekly.

To see more of, go to

CoQ10 - Pg 1 | Pg 2 | Pg 3 | References | Super Ubiquinol - Information/Ingredients/Dose

Order:   CoQ10 (Super-Absorbable) Coenzyme Supplements

Pay it Forward - Give You and Your Loved Ones the Gift of Health!
Sale - In addition to your 25% off, you get another 10% automatic volume discount at checkout on orders of $25 or more ... all items apply (including super sale items).  Just place your items in your shopping cart and it will calculate everything for you. Then, you can call us 817-335-1982 and we will complete the transaction for you via our secure credit card platform.  Or, you can print the completed form and send it with your check or money order.

We accept alll major credit cards or, PayPal.
Or , or send a check, money order, or cashiers check with completed order form.


Enjoy the benefits of our flat rate shipping and handling!  You receive the same great service for the same shipping price whether you order one item or one hundred!

$5.97 - Within USA only - US Post Office  5-9 business days.

$29.77 - To Canada only (see warning information here) 5-9 business days to customs check point (the only way we ship - US Post Office).

$49.77 - Outside USA only (see warning
here) 7-10 business days to your country's customs check point (the only way we ship - US Post Office).

Save 8.25% on all purchases - Texans and everyone!

It's all tax free!  You will be able to review all charges before they are charged to you.

At checkout (after you click the Add button on any of the order pages), the billing address you enter must match the address where you receive your credit card (security effects).  The shipping address you enter does not have to match.

All orders placed by Noon Central Standard Time (CST) are shipped the same day.  PO Boxes Okay.

Payment by credit card is immediate.  Payment by check adds a few more business days -- as soon as funds clear.

We do not sell the information you give us to anyone.

Protecting Your Personal Information
We pledge a safe and worry-free shopping experience using the industry standard for Internet security, 128-bit Secure Sockets Layer (SSL) encryption (see an online payments diagram).  SSL scrambles your personal and credit card information as it travels the Internet during the checkout process.  We utilize the Authorize.Net payment gateway.  Your credit card information is encrypted and sent to an Authorize.Net transaction server.  This server sends the data through the network to the card's bank, using a secure, proprietary connection.  When complete, you will receive an approval or decline response.  At no point is your credit card information stored on our server.

For additional information regarding the privacy of your sensitive cardholder data, please read the Authorize.Net Privacy Policy.

SmartBodyz Nutrition Home Page
1000 West 10th, Suite 218
Fort Worth, Texas 76102
Local Telephone: 817-335-1982
Email: DG[at] - replace [at] with @
(helps prevent spam)
Copyright 1996-2018, SmartBodyz Nutrition -- all rights reserved.

Credit Card Processing

Credit Card Processing

You can shop here with safety and confidence.  We have partnered with Authorize.Net, a leading payment gateway since 1996, to offer safe and secure credit card transactions.

The information and statements made throughout this web site have not been endorsed/evaluated by the Food and Drug Administration or any other governmental authority, unless otherwise specifically noted.  We do not offer products or services for the benefits or purpose of diagnosis, prescription for, treatment of, or claims to prevent, mitigate or cure any viral or disease condition or be free from side effects.  Please, seek the advice of a competent medical professional about anything you read on our site.

BlogBlogLinks | Testimonials | Privacy | RSS Feed