Cognitex w/Brain Shield/Gastrodin - Pregnenolone, Phosphatidylserine, Acetylcholine, Vinpocetine, Phosphatidylcholine - Side Effects/Dose

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Cognitex with Brain Shield/Gastrodin
With and Without Pregnenolone Complex

Pregnenolone, Phosphatidylserine, Acetylcholine, Vinpocetine, Phosphatidylcholine

Cognitex has been reformulated to take advantage of new developments and ingredients for cognitive health.  The newest ingredients in the Cognitex formula are two standardized wild blueberry extracts that provide the most active constituents found in this positive side effects heath-promoting fruit.

Blueberry anthocyanins are considered natures most potent antioxidants and have demonstrated properties that extend well beyond suppressing free radicals and side effects.  Pterostilbene is another blueberry constituent that helps maintain healthy lipid and glucose levels in those already within normal range.8  Importantly, through their unique biological effects; pterostilbene and anthocyanins may help support DNA structure.The Life Extension Cognitex formulas provides blueberry extracts standardized with both anthocyanins and pterostilbene.

A crucial building block in the brain is phosphatidylserine (PS).  In fact, brain tissues are especially rich in this brain nutrient, but aging causes a decline in the PS content of cells throughout the body, which can lead to cognitive decline.  Phosphatidylserine helps the brain use its fuel efficiently. 

By boosting glucose metabolism and stimulating production of acetylcholine (ACh - which specifically addresses learning and short-term memory), supplemental phosphatidylserine has been shown to improve the condition of patients experiencing age-associated memory impairment or cognitive decline and associated side effects.10,11  Thus, replacing this brain food is essential.

Gastrodin acts as a "brain shield," calming brain cells and helping to protect against oxidant, inflammatory, and excitatory damage. Gastrodin's multiple modes of action work together to improve circulation and shield the brain from age-related insults.

Life Extension's new generation Cognitex formulas now contain a rich PS compound that mimics the naturally occurring PS in the brain.  SharpPS GoldTM fortified with omega-3 fatty acids, delivers unique brain-health benefits to help retard the cognitive degeneration so often seen with advanced age.  These unique brain nutrients have been extensively studied and may be of tremendous benefit for the aging brain.12

More Protection Against Side Effects Laden Free Radicals
The brain is a highly active organ that produces high levels of free radicals from normal metabolism.  These free radicals can bombard the fatty membranes of neurons and other brain cells causing premature loss of function.  Cognitex contains a number of phytonutrient-based antioxidants that work best in a lipid (fat) rich environment like the brain.

While antioxidant nutrients provide essential free radical protection, many have limited capacity once they have spared an electron to balance a free radical.  Cognitex now contains a novel rosemary extract that is rich in carnosic acid, which provides multi-step protection against free radicals in a process called the carnosic acid cascade.  At each step of free radical interaction a new compound is formed, which in turn is a powerful antioxidant in itself.

Bioavailable to the Brain
Nutritional support for the brain is challenging as a barrier called the blood-brain barrier keeps out toxins.  In addition, it hangs-on to beneficial nutrients and drugs.  Cognitex contains the grape seed extract Leucoselect Phytosome.  By pairing one molecule of proanthocyanidins from grape seed extract with two molecules of phosphatidylcholine from soy lecithin in the Phytosome, the uptake and distribution to target tissues of the grape seed polyphenols is enhanced.

Once in the brain, the polyphenols trap side effects dangerous hydroxyl free radicals that turn fat rancid.  These fats make up the outer lipid membrane of trillions of brain cells.  These polyphenols also protect blood circulation and oxygen flow to the brain by improving the tone and elasticity of blood vessels.

Molecular Size Matters
High levels of procyanidins from grape seed extract does not ensure an extract is going to have a beneficial effect on the brain.  Polyphenols with higher molecular weight cannot be absorbed.  Leucoselect Phytosome contains smaller size molecules for advanced therapeutic activity as the larger molecules are discarded during the extraction process.

A Difference You Can Feel
Taking dietary supplements can often be an act of faith as we often cannot feel what they are doing.  Cognitex provides the patented, non-stimulant phytonutrient called Sensoril.  Sensoril is a proprietary standardized extract of ashwagandha, also know as Indian ginseng, and used in Ayurvedic traditional medicine for boosting brain function and alleviating mental fatigue.  Advanced extraction practices now allows for a highly concentrated yet balanced brain nutrient.  The positive side effects can often be felt immediately with greater alertness and focus but without the jitteriness of stimulants.

Sensoril also helps modulate the stress response resulting in cortisol excretion.  Stress can be very damaging to the brain, especially memory function, and cortisol stimulates the body to release sugar (glucose) into the bloodstream.  Elevated levels of glucose can accelerate aging and increase fat storage leading to weight gain, especially in the abdomen.  In addition, the stress-modulating abilities of Sensoril can help stress-overeaters especially when it comes to carbohydrate cravings.

Advanced Inflammation Protection
Cognitex also contains a NeuroProtection Complex designed to provide highly concentrated standardized extracts of hops, ginger and rosemary known anti-inflammatory nutrients.  Perluxan is a phytonutrient derived from the hops plant that is beginning to be used in nutritional formulas for chronic inflammatory conditions.

Circulation is a Positive Side Effect to Cognitive Health
Brain cells such as neurons are fed by blood vessels.  Some of these microcapillaries can be so small that red blood cells carrying oxygen have difficulty passing through them.  Neurons are the key structure for cognitive functions including memory.  Vinpocetine enhances blood flow by dilating blood vessels and reducing blood viscosity.  Vinpocetine enhances cerebral metabolism by helping to maintain healthy blood flow and glucose levels in those already within normal range, which enhances oxygen utilization by neurons.

Additional Advanced Brain Nutrients
L-alpha glycerylphosphorylcholine (A-GPC) is naturally present in all of our cells.  Its importance to life and safety as a supplement are evidenced by its substantial presence in human breast milk.13,14  Acetylcholine is an essential neurotransmitter involved in muscle control, sleep, short term memory and cognition.  Its decline coincides with advancing age and is a hallmark of teh side effects associated with neurodegenerative decline.  Cognitex provides A-GPC as a crucial building block for the production of acetylcholine in the brain.15,16

Cognitex is available with pregnenolone.  Concentrations of this critical hormone are much higher in the brain and studies show that this hormone has numerous positive side effects and mental benefits.

All these ingredients work synergistically to promote optimal cognitex function.

Supplement Facts:  Serving Size - 3 softgels.  Servings Per Container - 30


Alpha-Glyceryl Phosphoryl Choline (A-GPC)

600 mg

Phosphatidylserine [SharpPS Gold Conjugated Phosphatidylserine-DHA (std. to 45% PS and 8% DHA) and phosphatidylserine]

100 mg

Pregnenolone (This ingredient is not included in Cognitex without Pregnenolone)

50 mg


20 mg

Phosphatidylcholine-Grape Seed Extract [Contains 50 mg of Leucoselect Phytosome grape seed extract (95% polyphenols) bound to 100 mg of phosphatidylcholine from soy]

150 mg

VitaBlue Wild Blueberry (Vaccinium angustifolium) 130:1 Extract (fruit) [std. to 14% Total Phenolics (21 mg), 4.9% Total Anthocyanins (7.35 mg), 660 ppm Pterostilbene (0.1 mg)]

150 mg

Sensoril Ashwagandha (Withania somnifera) Extract (root and leaves) [standardized to 8% withanolide glycoside conjugates (10 mg) and 32% oligosaccharides (40 mg)]

125 mg

Proprietary NeuroProtection Complex Blend
Perluxan Hops Extract (Humulus lupulus) Rosemary (Rosmarinus officinalis) Extract (leaves)

125 mg

New Ingredient:  Brain Shield/Gastrodin -- 50 mg

Other Ingredients:  Rice bran oil, gelatin, glycerin, soy lecithin, silicon dioxide, carob color, rosemary extract, purified water.

Contains fish (e.g., bass, flounder, cod) and soybeans.  Contains rice.  This product contains NO milk, egg, peanuts, crustacean shellfish, tree nuts, wheat, yeast, gluten, or corn.  Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Leucoselect is a registered trademark of Indena S.p.A.
Phytosome is a trademark of Indena S.p.A.
Perluxan is a trademark of Pharmachem Laboratories, Inc.
Sensoril is protected under US Patents Nos. 6,153,198 and 6,713,092 and is a registered trademark of Natreon, Inc.
VitaBlue is a registered trademark of VDF Futureceuticals, Inc.
SharpPS Gold is a trademark of Enzymotec Ltd.

Dose:  3 in the AM as soon as you awake and 3 more in the afternoon.  Taking it too late in the evening may have a tendency to keep you awake.

Note:  For some, taking this new Cognitex can cause hours of alertness so it may not be advisable to take near bedtime.  Also, Sensoril is an adpatogenic herb and like all adaptogens are effective by bringing balance within the body.  Someone who is mentally exhausted and needs rest may find that initial use of this product may bring on a feeling of needing to sleep.  This is normal and the body is responding to the need for rest.  Continued use of the product will bring on mental re-invigoration.

Caution:  Pregnenolone may affect hormone levels so those with hormonal cancs such as prostate or breast canc should use Cognitex without pregnenolone.  If you suffer from bi-polar (manic depressive) disorder, consult your physician before using Cognitex.*

A site that be helpful to see if Cognitex helps you is  You can perform a set of tasks and see your score as a pre-test.  Then, take Cognitex supplements for at least 2 weeks and then perform a post-test.  Compare your scores and see if you improved.

Warnings Information:

  • For dietary supplement use only,
  • If you are taking Warfarin (Coumadin), consult with your physician before using this product,
  • Keep Cognitex with Pregnenolone supplements out of reach of children,
  • Do not exceed recommended dosage,
  • If you have negative side effects, discontinue use immediately,
  • When using Cognitex with Pregnenolone supplements, please inform your physician,
  • If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement,
  • If side effects of allergic reaction occurs, discontinue immediately.


Pricing Information: Cognitex with or without Pregnenolone

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