Studies document that drinking eight glasses of cranberry juice twice a day can be helpful. As long as the cranberry juice is continued, problems are not likely to return. One way that cranberry juice works is to prevent unwanted out-of-control cellular activity.
Studies suggests that unwanted out-of-control cellular activity and the associated influx of white blood cells into the urine (pyuria) can be reduced by nearly 50 percent in elderly women who drink 300 mL of cranberry juice cocktail each day.
Laboratory studies have attempted to account for the effectiveness of cranberry juice and microscopic studies have focused on urine acidification.
When cranberry cocktail was given to mice in the place of their normal water supply for a period of 14 days, the adherence of unwanted out-of-control cellular activity to urinary wall cells was reduced by approximately 80 percent. Anti-adherence activity also could be detected in human urine. Fifteen of 22 subjects showed significant anti-adherence activity in the urine one to three hours after drinking 15 ounces of cranberry cocktail without side effects.
In urostomy patients, urinary wall issues are common and may stem from alkaline urine. Cranberry juice appears to acidify urine and is widely recommended for the reduction of unwanted out-of-control cellular activity. A recent study showed that drinking cranberry juice could help to prevent and/or improve complications and side effects for urostomy patients. It also showed that cranberry juice resulted in improvements of conditions and a reduction in complications in patients with severe urinary wall issues.
Most people would find it difficult to drink sixteen 8 ounce glasses of cranberry juice a day, but Cran-Max provides the equivalent of eight 8 ounce glasses of cranberry juice in just one capsule. That means that people predisposed to urinary tract problems and its side effects need to take only two capsules to consume the active ingredients in sixteen 8 ounce glasses of cranberry juice.Unlike many diluted cranberry supplements, each vegetarian capsule:
American Medical Association. "Urinary Tract: A Patient's Guide." Pamphlet. 1997 edition.
Avorn J, et al. The ingestion of cranberry juice. JAMA. 1994. 271: 751.
Cape Cod Biolab Corporation. Annual incidence of urinary tract health in the U.S. Private report. Jan 11, 1999.
Carlson KJ, et al. "Urinary tract issues" chapter. The Harvard Guide to Women's Health, published by Harvard University Press. 1996. P. 617-619.
Collins MM, et al. "How common is? A national survey of physician visits." J Urol. h1998; 158: 1224-1228.
Cox SM, et al. "In pregnancy: cause, symptoms, treatment and prevention and side effects." Clin Prac Sexuality. 1989; 5(1) 21-26.
Fowler JE. "Urinary tract in women." Urol Clinics of No Am., 1986; 13-4: 673-681.Haverkorn MJ, et al. Reduction of out-of-control cellular activity using cranberry juice [letter]. JAMA. 1994; 272-590.
Healthy Life. "The power of the whole cranberry." Article. 1998; 1(3), p. 1.
Howell AB, et al. Inhibition of the adherence of P-fimbriated E. coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries [letter]. N Engl J Med. 1998; 339:1085-1086.
Iravani A. "During pregnancy." Clin Adv Treatment Infect. Oct,1988: 2(5)1 p.9.
National Business Journal. "Cranberry supplement ingredient captures attention of vitamin manufacturers." June,1998: p. 11.
National Institute of Digestive and Kidney Problems (NIH). "Urinary Issues in Adults." Pamphlet.
Ofek I, et al. "Anti-E. coli adhesion activity of cranberry and blueberry juices." N Eng. J Med. 1991; 324:1599.
Schmidt DR, Sobata AE. "An examination of the anti-adherence activity of cranberry juice on isolates." Microbios. 1998; 55: 173-181.
Sobata AE. "Inhibition by cranberry juice: potential use for the treatment." J Urol. 1984; 131:1013-1016.
Stamm WE, et al. "Management of Urinary Problems in Adults." N Engl J Med. Oct 28, 1993, pg. 1328.
U.S. Dept. of Health & Human Services. "Urinary Issues in Adults." NIH publication No. 91-2097.
U.S. News & World Report. "Losing the Battle of the Bugs." Coverstory. May 10, 1999.
Zafriri, et al. "Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated E. coli to eucaryotic cells." Anti Microb Agents Chemother. 1989: 33: 99-8.
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