Dehydroepiandrosterone (DHEA) 7-keto Supplements Side Effects, Levels, Benefits - Dose

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Dehydroepiandrosterone (DHEA) 7-Keto Supplements Side Effects, Levels, Benefits

DHEA (dehydroepiandrosterone) 7-Keto -- 25 mg and 100 mg

Among DHEA's many metabolites, one has attracted significant attention for its unique ability to lower cholesterol, burn fat, and improve the immune system.  This metabolite, known at 7-Keto DHEA, is not converted into estrogen or testosterone, so it may be safely used among people with hormone-dependent diseases, including canc.

Scientific studies have shown that 7-Keto can help people burn fat through a process known as thermogenesis.  This means the body's metabolic rate is accelerated, generating heat and energy that consumes calories and burns fat.  7-Keto accomplishes this by boosting the levels of three liver enzymes that stimulate fatty acid oxidation.

In one study of 30 overweight adults, study subjects either received 100 mg of 7-Keto twice daily or placebo.  They also participated in a supervised exercise and diet program.  At the end of the study, those taking 7-Keto had lost 6.3 pounds on average, versus 2.1 pounds for the control group (Kalman DS et al 2000).

7-Keto has also been studied for its immune-boosting and cholesterol-lowering properties.  In a study on cholesterol levels, human volunteers applied a gel containing 25 mg of 7-Keto for five consecutive days.  At the end of the study, the subjects taking 7-Keto had experienced a rise in good HDL cholesterol and a slight reduction in harmful LDL cholesterol (Sulcova J et al 2001).

Another study looking at immune function found that four weeks of 7-Keto supplementation improved immune function in elderly men and women. In this study, subjects over age 65 took 100 mg of 7-Keto twice daily or placebo. The subjects on 7-Keto experienced a significant decrease in immune suppressor cells and an increase in immune helper cells (Zenk JL et al 2004).

Because 7-Keto is not converted into estrogen or testosterone, it may be the perfect complement to DHEA therapy, as well as providing an option for people who have hormone dependent cancs. In some women, high doses of DHEA may cause the growth of unwanted hair or acne. By adding 7-Keto to a daily program, it may be possible to lower the dosage of DHEA.

In 1981, the Life Extension Foundation introduced DHEA (dehydroepiandrosterone) through an article that described the multiple benefits it might produce virtually side effects free.  However, the general public did not learn about DHEA until 1996, when the benefits of DHEA 7-keto were touted by the news media and in several popular books.

It has been shown that DHEA often declines 80-90% by age 70 or later, leading to imbalances that can affect ones quality of life.  Peak blood levels of DHEA occur at approximately age 25, decreasing progressively thereafter.  Thus, scientists have been looking at ways of restoring DHEA benefits to youthful levels.  People over age 40 usually have serum levels below 200 and many are below 100.

Life Extension DHEA 7-keto supplements conform to the following specifications:

  • 99.9% purity,
  • Micronized (for maximum absorption and utilization),
  • Manufactured under GMP (Good Manufacturing Practice) conditions.

DHEA Dosing and Safety Precautions Information
The Life Extension Foundation has been investigating DHEA for more than 20 years.  Life Extension's DHEA directions for use are specially drafted to provide optimal and side effects free safe dosing.   A DHEA-S (dehydroepiandrosterone sulfate) blood test may be taken three to six weeks after initiating DHEA supplementation regimen to help determine optimal dosing.  When having your blood tested for DHEA, blood should be drawn three to four hours after the last dose for the most benefits.  DHEA testing may save you money if it shows that you can take less DHEA to maintain serum levels.

The standard blood test to evaluate DHEA status is one that measures DHEA-S.  The DHEAS is calculated in micrograms per deciliter (mcg/dL) of blood.

The ranges of DHEA are as follows (mcg/dL):  Men; 400-560.  Women; 350-430

For Men, when taking DHEA 7-keto, it may be prudent to consider taking the following other nutrients to maintain a healthy balance.

Vitamin E Succinate (natural)

400-800 IU daily

Selenium (a mineral included in Life Extension Mix)

200 mcg daily

Mega Soy Extract (40% isoflavone extract from the soy bean plant)

135 mcg twice daily

Lycopene Extract (the red pigment found in tomatoes and several fruits -- included in Natural Prostate and Life Extension Mix)

20-30 mg daily

Saw Palmetto Extract (an extract form a form of palm tree)

160 mg twice daily

Pygeum Extract (an herb included in Natural Prostate)

50 mg twice daily

Nettle Extract (an herb included in Natural Prostate)

120 mg twice daily

Gamma tocopherol (a form of vitamin E)

200 mg daily

Boron (a mineral included in Life Extension Mix)

3-10 mg daily

For Women, when taking DHEA 7-keto it may be prudent to consider taking the following other nutrients to maintain a healthy balance.


300 mcg to 3 mg nightly

Vitamin E Succinate (natural)

400-800 IU daily

Mega Soy Extract (40% isoflavone extract)

135 mg twice daily

Indole-3-carbinol (I3C)

200 mg two to four times daily

Vitamin D3

1000-1400 IU daily

Gamma tocopherol

200 mg daily


Supplements Facts Information for 7-Keto, 25 mg:

 Serving Size - 1 Capsule.  Servings Per Container - 100.

Amount Per Serving

DHEA (3-acetyl-7-oxo-dehydroepiandrosterone) 7-keto

25 mg

Other ingredients: Rice flour, gelatin, vegetable stearate. Contains rice. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives. 7-Keto is a registered trademark of Humanetics Corp.

Supplements Facts Information for 7-Keto, 100 mg:

 Serving Size - 1 Vegetarian Capsule.  Servings Per Container - 60.

Amount Per Serving

DHEA (3-acetyl-7-oxo-dehydroepiandrosterone) 7-keto

100 mg

Ascorbyl palmitate

25 mg

BCM-95 Bio-Curcumin (Curcuma longa) 25:1 extract (root) [std. to 95% Total Curcuminoids Complex with Essential Oils of Turmeric Rhizome by HPLC (23.75 mg)]

25 mg

Green tea (Camellia sinensis) decaffeinated extract (leaf) [standardized to 98% polyphenols (24.5 mg)]

25 mg

Polygonum cuspidatum (root) and whole red grape (Vitis vinifera) extract [std. to 35% trans-resveratrol (1 mg)]

3 mg

Other ingredients: Rice flour, vegetable cellulose (capsule), vegetable stearate.

Dosage and Use InformationGenerally, take one to four capsules in the morning and/or afternoon.  Taking DHEA (dehydroepiandrosterone) with fat or an oil based capsule (such as flax seed or krill oil) enhances absorption.  DHEA serum blood tests are suggested 3 to 6 weeks after initiating DHEA replacement therapy to optimize individual dosing.  Do not take in the evening as it could interfere with sleep.

Warnings Information:

  • Keep out of reach of children,

  • Do not exceed recommended dose for maximum benefits,

  • If you have a bad reaction or side effects, discontinue use immediately,

  • When using DHEA 7-keto dehydroepiandrosterone supplements, please inform your physician.

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