It reverses inflammation and restores filtration. Similar findings are reported by French researchers when NAC is given as a pre-treatment before experimental kidney damage in rats. Without NAC, there is a 68% reduction in the ability of the kidneys to do their job. With it, the loss of kidney function is only 29%. A third study confirms that an infusion of NAC before and after experimental kidney damage doubles the kidney filtration rate. NAC is strong medicine for the kidneys. It has no adverse side effects, even when small animals like cats are given a human dose.
The veterinarian started Jack on 100 mg of NAC twice a day, plus a new diet of raw beef and chicken and 100 mg of DHEA (dehydroepiandrosterone). DHEA is critical for an important kidney enzyme known as sulfotransferase. People with kidney disease have depleted levels of DHEA. Research shows that DHEA and NAC probably work synergistically, which is why they were given together.
Within 24 hours of receiving NAC and DHEA, Jack began eating like a normal cat. He continued to vomit for several days (a side effect of kidney failure), but two weeks from the date of surgery, his BUN had dropped from 152mg/dl to 45.6mg/dl and he was up and around. At that point, the supplements were cut in half. A month later, Jack's blood tests were normal. That was over a year ago and Jack is still doing great. He is maintained on a high-protein diet along with 50 mg of NAC and 25 mg of DHEA a day.
Zoe, the Hairless Dog
"Flea allergy" or "food allergy" is a common diagnosis for animals loosing their hair. It's a quick, eye-ball diagnosis rarely accompanied by laboratory tests. The cure is usually steroids plus one of the new pesticides that is put on the back of the animal and absorbed through the skin. The problem is that fleas are only one of many things that can cause hair loss, which is usually accompanied by some sort of skin disorder.
Researchers from Hungary recently reported that 17 dogs treated with pesticides, "restricted diets," steroids, antibiotics and other medications did not respond because they were infected with microorganisms that are not usually regarded as a problem. Yet when the bugs were eradicated with the proper drugs, the dogs got well. This points out the importance of finding the root cause of a persistent problem.
Another cause of hair loss is poor nutrition. There is considerable evidence that the nutritional requirements for dogs depends on the breed. It appears that dogs prone to certain disorders also require certain dietary needs. English setters, for example, can inherit a terrible disease called Batten disease which causes the brain to shrink. It is accompanied by abnormally low levels of polyunsaturated fatty acids and the amino acid, l-carnitine. Researchers at Indiana University wanted to see if it would help to supplement the animals diets' with l-carnitine, omega 3 fatty acids (flax seed oil) and corn oil. It did. Carnitine greatly reduced cognitive decline, and the combination reduced brain atrophy and extended lifespan 10%.
In 1988, veterinarians at the University of California at Davis reported on 13 dogs that had been eating a generic dry, corn and wheat-based dog food. The dogs were depressed and lethargic. They had swollen lymph nodes and, worst of all, they had scaly, crusting areas where their fur was falling out. The dog food label did not state that it met minimum nutritional requirements (AAFCO). When the animals were put on a higher-quality dog food, the animals began to get better within days.
Aging and Dementia in Dogs
There are various supplements an owner can give their animals to protect them from degenerative diseases. DHEA (dehydroepiandrosterone), for example, is a hormone secreted by the adrenal glands that declines drastically with age. In a study from Purdue University, 100 mg/kg of DHEA a day given as a supplement for seven months to elderly dogs reduced the percentage of brain cells with extensive DNA damage by 42%. This shows that even an elderly animal can benefit from anti-aging interventions. In the same study, damage to the dogs' immune cells was cut in half. This is good health news for pet owners. Note that both types of cells (immune and brain) are extensively damaged in people with Alzheimer's disease. Its antioxidant action may account for DHEA's ability to protect these vital cells.
There are other methods to protect the brain as well. When the Science Diet people went looking for a supplement that could help aging dogs stay alert, they focused on two important aspects of brain aging -- energy and free radical damage.
The brain's energy is generated by sub-cellular structures called "mitochondria." When mitochondria make energy, free radicals are created. Free radicals, in turn, damage mitochondrial DNA. Damaged DNA, in turn, prevents the little power plants from producing energy efficiently. The vicious cycle is accelerated by age.
The brain is very susceptible to free radical damage because of its high fat content and high demand for energy. One of the most powerful brain antioxidants is alpha lipoic acid, also known as lipoic, or thioctic acid. Lipoic acid has multiple actions. On one level, it restores and maintains other antioxidants including vitamins C and E, and the natural antioxidant, glutathione. Glutathione is diminished in the brains of elderly dogs. Lipoic acid also enhances the level of coenzyme Q10, an energy-related enzyme, and restores arachidonic acid in brain cells to youthful levels. Arachidonic acid is absolutely critical for learning and remembering. Researchers have demonstrated that restoring arachidonic acid to youthful levels through supplements increases the ability of neurons to respond. In other words, arachidonic acid may be the key to teaching an old dog new tricks.
Additionally, alpha lipoic acid can chelate iron and other metals, keeping them from fueling free radical chain reactions. By itself, lipoic acid is highly protective of brain cells, but there is another element that can be combined with it that makes it even more powerful -- l-carnitine.
As great as it was to get the old mice up and going again, their increased energy came with a price -- a 30% increase in free radicals. This is where lipoic acid comes into the picture. When the same researchers added lipoic acid to the l-carnitine supplements, oxidative stress was reduced to the level of youngsters and physical activity was even greater than that achieved with lipoic acid alone. Memory was enhanced, and when the researchers looked at the hippocampus (a brain structure having to do with memory) they found that the combination of l and lipoic acid actually kept the mitochondria from aging.
For years nobody paid much attention to the diets of their cats and dogs. They got the scraps off the table, or the mice from the barn, and that was about it. But when these animals began being used in laboratories, it became imperative to know their nutritional requirements. "Complete and balanced nutrition" pet food is a billion dollar offshoot of "lab chows." The industry has contributed substantially to understanding the nutritional requirements of our "best friends." But science is moving on now, beyond what it takes to keep an animal on its feet, to what it takes to keep an animal healthy in the long run. New research shows that cats and dogs respond positively to some of the same supplements we take. Lower vet bills and happier animals is our reward for optimal nutrition.
To view which brands of dog food contained detectable levels of pentobarbital in the FDA study, see http://www.fda.gov/cvm/efoi/DFchart.pdf. For a brief report of the study, see http://www.fda.gov/cvm.
Earth Island Institute has done several reports on commercial pet food and rendering plants, including "The Dark Side of Recycling", fall 1990; "Food Not Fit for A Pet", summer 1996. "Look Inside" a Rendering Plant, summer 1996. See www.earthisland.org.
Cats are strict carnivores. Their requirement for meat protein is three times higher than omnivores like dogs. They must have meat protein to maintain health. Meat should be the first ingredient in a cat's diet. Commercial pet food made with human-grade meat is available online. Brands include Wysong, Wellness, PetGuard and Active Life. Darwins Natural Products http://www.darwinsnaturalpet.com/ is fresh, all-natural meals for your dog delivered right to your door. http://www.azmira.com/ProductFoods.htm is holistic food for your animals and may be found in your area.
Ann Martin looked into the pet food industry after her own dog almost died from contaminated commercial dog food. An updated version of her book, Food Pets Die For is now available for $13.95. Call, toll-free, 877-695-2211 or visit www.newsagepress.com. The book is also available through bookstores online.
Martin Goldstein is a Cornell-educated veterinarian who practices holistic vet care. The Nature of Animal Healing. (Knopf 1999).
In addition, a good resource book is available for download - Ninety percent of all pet health problems are caused by pet food and preventable health hazards.
Pet Foods Unfit for Animals - Pg 1 | Life
Extension Cat Mix - Dose
| Dog Mix with Ground Flax Seed - Dose
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