EPA/DHA (Omega 3 Fatty Acids) - Anxiety, Substance Abusers

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Omega-3 Fatty Acids Decrease Anxiety in Substance Abusers
Reprinted by permission from Pat Whittington of Complementary Prescriptions

A new study has found that omega-3 fatty acids found in fish oil decrease feelings of anxiety in substance abusers, adding to the mounting evidence that fish-oil-derived fatty acids can improve well-being.

Past studies have shown that omega-3 fatty acids have a role to play in alleviating depression and that their deficiency may be associated with bipolar disorder.  Pre-clinical studies also have shown that omega-3 fatty acids decrease anxiety-like behaviors.  Because there is a strong association between anxiety disorders and substance use disorders and because substance abusers have poor dietary habits, researchers investigated the theory that omega-3 supplements would decrease anxiety in a group of substance abusers.
In the three-month, randomized, double-blind trial, researchers gave 13 patients capsules containing 3 grams of omega-3 fatty acids (EPA/DHA -- eicosapentaenoic acid plus docosahexaenoic acid) per day.  Eleven patients received placebo capsules.

At the start of  the study and on a monthly basis thereafter, the researchers administered a scale assessing anxiety feelings.  Six patients consuming the omega-3 supplements and 8 placebo group patients were followed for an additional three months after treatment discontinuation and administered the same questionnaire monthly.

Subjects who received the omega-3s for three months showed a progressive decline in anxiety scores.  This same improvement was not noted in the placebo group.  A comparison of the two groups showed that there was a significant difference between those taking the omega-3s and the subjects taking the placebo.  Furthermore, for three months after treatment discontinuation, anxiety scores remained significantly decreased in the omega-3 group.

In conclusion, the researchers wrote, these preliminary data indicate that n-3 PUFA [omega-3 fatty acid] supplementation could be beneficial in the treatment of some patients with anxiety disorders.

Buydens-Branchey L, Branchey M.  n-3 Polyunsaturated Fatty Acids Decrease Anxiety Feelings in a Population of Substance Abusers.  Journal of Clinical Psychopharmacology.  December 2006;26(6):661-665.


  • Two softgels may be taken up to three times daily if so directed by a healthcare practitioner or see above,
  • Do not take with fiber supplements,
  • The olive polyphenols in Polyphen-Oil protect against LDL oxidation, suppress free radicals, and stabilize cell membranes,*
  • Each serving of two softgels provides the amount of polyphenols equivalent to drinking two ounces of virgin olive oil.

If you are taking anticoagulant drugs, use only under the supervision of your physician.  Blood tests that measure clotting time can be used to ensure these nutrients are not reducing the clotting factors in your blood to abnormal levels.

Note:  It is important to refrigerate Super EPA / DHA Omega 3 fatty acids supplements once they are received for the most benefits.


  • Keep out of reach of children,

  • Do not exceed recommended dose,

  • If you have a bad reaction, discontinue use immediately,

  • When using Super EPA / DHA Omega 3 fatty acids supplements in the battle against substance abuse or as an anti-anxiety supplement, please inform your physician.

Pricing Information:   Super EPA / DHA Omega 3 fatty acids Supplements

Articles:  Docosahexaenoic (DHA) Essential Fatty Acids (EFA) - Nutrition Research |

Junk-food Diet 'Makes Children Badly Behaved' - Omega 3 Fatty Acids


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