GABA (gamma amino butyric acid) Supplement - Side Effects, Dose

Welcome To
SmartBodyz Nutrition
Your Online Source for Nutritional Supplements and Related Research

GABA - 227gm (8 ounces) Pure Powder by Source Naturals PharmaGABA - 60 Chewable Tablets by Dr. Michael Murray
Home Products
Amazon Shopping Terms and Conditions MX GuardDog Spam Blocker View Cart
Live Search
Buy anything from eBay!

GABA (gamma amino butyric acid) Supplement - Side Effects, Dose

227 grams pure powder or 60 chewable tablets

GABA (gamma-amino butyric acid) is an inhibitory neurotransmitter, helping neurons stay selective about the signals to which they respond and helping produce a state of relaxation.  Taken at bedtime, supplemental GABA may assist some people in the initiation of sleep and produce a deeper and more beneficial sleep.

Gamma-amino butyric acid (GABA), the brains major inhibitory neurotransmitter, tends to be in lower than normal levels in seizure-prone rats (1) and humans with epilepsy.(2)  Seizure-prone preeclamptic patients (hypertensive condition during late pregnancy) also have decreased brain GABA concentrations.(3)  Brain GABA levels depend on both zinc and vitamin B6.  Zinc is involved in the maintenance of pyridoxal phosphate (a form of vitamin B6) concentrations by the activation of pyridoxal kinase (enzyme participates in vitamin B6 metabolism).  Pyridoxal kinase is important in decarboxylation, and lack of this enzyme results in lowered brain levels of GABA.  Consequently, zinc deficiency may increase the risk of pre-eclamptic seizures by reducing brain GABA concentrations and lowering the seizure threshold.  Unfortunately, plasma pyridoxal phosphate measurements alone do not appear to accurately reflect vitamin B6 status or true tissue pyridoxal phosphate levels.(3)

In addition to vitamin B6, magnesium and dimethylglycine (DMG) may result in an appearance of speech in formerly non-speaking autistic children.  Magnesium, vitamin B6 and dimethylglycine (DMG) all have strong anti-seizure properties and may be effective in this regard.(5)  The deficiency of another member of the B-complex, B1, has also been reported as a contributor to epileptic seizures.(6)

British researchers have found that the age-related decline in higher brain functions is due, in large part, to a lack of the inhibitory neurotransmitter, GABA.  Higher brain functions, such as visual recognition and language comprehension, decline as people get older.  This decline appears to be due to a reduction of GABA, which results in neurons with specific tasks being more easily fired by some other types of stimulus, slowing down processing of information in the brain.

As people age, brain neurons increasingly fire non-selectively, and interpreting information then becomes like listening to whispering in the discotheque as opposed to shouting in a quiet room.  The new research shows that GABA works as a gating mechanism to help neurons remain selective when responding to stimuli to enable the brain to make sense of the vast quantity of incoming information.

When old Macaque monkeys, equivalent to 90-year-old humans, were treated with GABA and drugs that increase GABA levels in the brain, their performance on tests for brain functions improved vastly within a couple of minutes.  The fact is, all the cells are still there and functioning -- it is a transmitter problem -- its treatable.  While doctors have observed the paradoxical effect of GABA-enhancing drugs making people more alert, this is the first study to show that increasing GABA or its effects may support mental function.

Another consideration for increasing GABA levels is via the amino acid L-glutamine The glutamine cycle in the brain is simple and elegant.  Glutamine readily crosses the blood-brain barrier.  Neurons take up glutamine and convert it to glutamate or GABA (through the additional step of decarboxylating glutamate).  After either glutamate or GABA are released into the synaptic junction, the supportive cells called glia take up the glutamate or GABA and re-synthesize glutamine -- detoxifying ammonia in the process. The glutamate that is not converted to l-glutamine is used by the glia as a source of energy and also to produce energy nutrients alanine and alpha-ketoglutarate which are then released to the neurons.

Supplement Facts:  227gm (8 oz) Pure Powder.  Serving Size - 1/4 teaspoon.  Amount / Serving

GABA (gamma amino butyric acid)

750 mg

This product contains NO sugar, yeast, wheat, gluten, corn, soy or dairy. Contains NO artificial color, sweeteners, flavors or preservatives.

Supplement Facts:  60 Chewable Tablets.  Serving Size - 2 Tabs.  Servings/Container - 30.  Amount/Serving




3 gm

GABA (gamma amino butyric acid)

200 mg

Stevia powder extract (leaf)

10 mg

Other ingredients:  Sorbitol, xylitol, stearic acid, magnesium silicate, silica, fruit flavor (orange and tangerine), citric acid.  Contains milk. Contains NO artificial color or sweeteners; no soy, wheat or yeast.

PharmaGABA is a trademark of Pharma Foods International Co., Ltd.. (Japan).

Dosage and Use

  • 1/8 - 1/4 teaspoon before sleep or chew 1-2 tablets, up to 3 times per day or as directed by a health professional.  GABA is most effectively utilized when taken on an empty stomach,
  • The powder is easily soluble in juice or water and has a pleasant taste,
  • GABA (gamma-amino butyric acid) powder may also be dissolved in the mouth for quicker assimilation.

Caution:  Refrain from taking more than 800mg per dose.


  • Keep GABA (gamma amino butyric acid) amino acid supplements out of reach of children,

  • Do not exceed recommended dose,

  • If you have a reaction or side effects, discontinue use immediately,

  • When using GABA (gamma amino butyric acid) amino acid supplements, please inform your physician.

 Order:   GABA (gamma amino butyric acid) | L-Theanine | L-Glutamine | OptiZinc | Magnesium | Vitamin B6

Pay it Forward - Give You and Your Loved Ones the Gift of Health!
Sale - In addition to your 25% off, you get another 10% automatic volume discount at checkout on orders of $25 or more ... all items apply (including special sale items).  SECURE SHOPPING CART CREDIT CARD PURCHASES ONLY.  Call-ins do not receive this special discount.

All major credit cards accepted
Or , or send a check, money order, or cashiers check with completed order form.

1. Lasley, S. M. Role of Neurotransmitter Amino Acids in Seizure Severity and Experience in the Genetically Epilepsy-Prone Rat. Brain Res, 1991; 560:63-70
2. During, M.J. and Spencer, D. D. Extracellular Hippocampal Glutamate and Spontaneous Seizure in the Conscious Human Brain. The Lancet, June 26, 1993; 341 (8861): 1607-1610
3. Anonymous. Zinc, Preeclampsia, and Gamma-Aminobutyric Acid. Am Jnl of Obst & Gyn, July 1990, 163, 1, (Part I): 242-243
4. Baumeister, F. Glutamate in Pyridoxine-Dependent Epilepsy: Neurotoxic Glutamate Concentration in the Cerebrospinal Fluid and Its Normalization by Pyridoxine. Ped, September 1994, 94 (3): 318-321
5. Seizures, Vitamin B6, DMG, and Sudden Speech Autism, Res Rev Intl, 1996, 10 (2): 1
6. Keyser, A. Epileptic Manifestations and Vitamin B1 Deficiency. Eur Neuro, 1991, 31: 121-125.


Enjoy the benefits of our flat rate shipping and handling!  You receive the same great service for the same shipping price whether you order one item or one hundred!

$5.97 - Within USA only - US Post Office  5-9 business days.

$29.77 - To Canada only (see warning information here) 5-9 business days to customs check point (the only way we ship - US Post Office).

$39.77 - Outside USA only
(see warning here) 7-10 business days to your country's customs check point (the only way we ship - US Post Office).

Save 8.25% on all purchases - Texans and everyone!

It's all tax free!  You will be able to review all charges before they are charged to you.

At checkout (after you click the Add button on any of the order pages), the billing address you enter must match the address where you receive your credit card (security effects).  The shipping address you enter does not have to match.

All orders placed by Noon Central Standard Time (CST) are shipped the same day.  PO Boxes Okay.

Payment by credit card is immediate.  Payment by check adds a few more business days -- as soon as funds clear.

We do not sell the information you give us to anyone.

Protecting Your Personal Information
We pledge a safe and worry-free shopping experience using the industry standard for Internet security, 128-bit Secure Sockets Layer (SSL) encryption (see an online payments diagram).  SSL scrambles your personal and credit card information as it travels the Internet during the checkout process.  We utilize the Authorize.Net payment gateway.  Your credit card information is encrypted and sent to an Authorize.Net transaction server.  This server sends the data through the network to the card's bank, using a secure, proprietary connection.  When complete, you will receive an approval or decline response.  At no point is your credit card information stored on our server.

For additional information regarding the privacy of your sensitive cardholder data, please read the Authorize.Net Privacy Policy.

SmartBodyz Nutrition Home Page
1000 West 10th, Suite 218
Fort Worth, Texas 76102
Local Telephone: 817-335-1982
Email: DG[at] - replace [at] with @
(helps prevent spam)
Copyright 1996-2017, SmartBodyz Nutrition -- all rights reserved.

Credit Card Processing

Credit Card Processing

You can shop here with safety and confidence.  We have partnered with Authorize.Net, a leading payment gateway since 1996, to offer safe and secure credit card transactions.

The information and statements made throughout this web site have not been endorsed/evaluated by the Food and Drug Administration or any other governmental authority, unless otherwise specifically noted.  We do not offer products or services for the benefits or purpose of diagnosis, prescription for, treatment of, or claims to prevent, mitigate or cure any viral or disease condition or be free from side effects.  Please, seek the advice of a competent medical professional about anything you read on our site.

BlogBlogLinks | Testimonials | Privacy | RSS Feed