GABA Calm Mind by Source Naturals & ComfortMAX by Life Extension
GABA (gamma-amino butyric acid) is an inhibitory neurotransmitter, helping neurons stay selective about the signals to which they respond and helping produce a state of relaxation.
Taken at bedtime, supplemental GABA may assist some people in the initiation of sleep and produce a deeper and more beneficial
Gamma-amino butyric acid (GABA), the brains major inhibitory neurotransmitter, tends to be in lower than normal levels in seizure-prone rats (1) and humans with epilepsy.(2)
Seizure-prone preeclamptic patients (hypertensive condition during late pregnancy) also have decreased brain GABA concentrations.(3)
Brain GABA levels depend on both zinc and vitamin B6.
Zinc is involved in the maintenance of pyridoxal phosphate
(a form of vitamin B6) concentrations by the activation of pyridoxal kinase
(enzyme participates in vitamin B6 metabolism).
Pyridoxal kinase is important in decarboxylation, and lack of this enzyme results in lowered brain levels of GABA.
Consequently, zinc deficiency may increase the risk of pre-eclamptic seizures by reducing brain GABA concentrations and lowering the seizure threshold.
Unfortunately, plasma pyridoxal phosphate measurements alone do not appear to accurately reflect
vitamin B6 status or true tissue pyridoxal phosphate levels.(3)
In addition to vitamin B6,
magnesium and dimethylglycine
(DMG) may result in an appearance of speech in formerly non-speaking autistic children.
Magnesium, vitamin B6 and
(DMG) all have strong anti-seizure properties and may be effective
in this regard.(5)
The deficiency of another member of the B-complex, B1, has also been reported as a
contributor to epileptic seizures.(6)
British researchers have found that the age-related decline in higher brain functions is due, in large part, to a lack of the inhibitory neurotransmitter, GABA.
Higher brain functions, such as visual recognition and language comprehension, decline as people get older.
This decline appears to be due to a reduction of GABA, which results in neurons with specific tasks being more easily fired by some other types of stimulus, slowing down processing of information in the brain.
As people age, brain neurons increasingly fire non-selectively, and interpreting information then becomes like listening to whispering in the discotheque as opposed to shouting in a quiet room.
The new research shows that GABA works as a gating mechanism to help neurons remain selective when responding to stimuli to enable the brain to make sense of the vast quantity of incoming information.
When old Macaque monkeys, equivalent to 90-year-old humans, were treated with GABA and drugs that increase GABA levels in the brain, their performance on tests for brain functions improved vastly within a couple of minutes.
The fact is, all the cells are still there and functioning -- it is a transmitter problem
-- its treatable.
While doctors have observed the paradoxical effect of GABA-enhancing drugs making people more alert, this is the first study to show that increasing GABA or its effects
support mental function.
Another consideration for increasing
GABA levels is via the amino acid
The glutamine cycle in the brain is simple and elegant.
Glutamine readily crosses the blood-brain barrier. Neurons
take up glutamine and convert it to glutamate or GABA (through the
additional step of decarboxylating glutamate). After either
glutamate or GABA are released into the synaptic junction, the
supportive cells called glia take up the glutamate or GABA and
re-synthesize glutamine -- detoxifying ammonia in the process. The
glutamate that is not converted to l-glutamine is used by the glia
as a source of energy and also to produce energy nutrients alanine
alpha-ketoglutarate which are then released to the neurons.
Calm Mind by Source Naturals:
amino butyric acid)
Other ingredients: gelatin (capsule), silica, and magnesium stearate.
Hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
This product contains NO sugar, yeast, wheat, gluten, corn, soy or dairy. Contains NO artificial color, sweeteners, flavors or preservatives.
Dosage and Use:
1 capsule daily.
for GABA above:
1. Lasley, S. M. Role of
Neurotransmitter Amino Acids in Seizure Severity and Experience in
the Genetically Epilepsy-Prone Rat. Brain Res, 1991; 560:63-70 2. During, M.J. and Spencer, D. D. Extracellular Hippocampal
Glutamate and Spontaneous Seizure in the Conscious Human Brain. The
Lancet, June 26, 1993; 341 (8861): 1607-1610 3. Anonymous. Zinc, Preeclampsia, and Gamma-Aminobutyric Acid. Am
Jnl of Obst & Gyn, July 1990, 163, 1, (Part I): 242-243 4. Baumeister, F. Glutamate in Pyridoxine-Dependent Epilepsy:
Neurotoxic Glutamate Concentration in the Cerebrospinal Fluid and
Its Normalization by Pyridoxine. Ped, September 1994, 94 (3):
318-321 5. Seizures, Vitamin B6, DMG, and Sudden Speech Autism, Res Rev
Intl, 1996, 10 (2): 1 6. Keyser, A. Epileptic Manifestations and Vitamin B1 Deficiency.
Eur Neuro, 1991, 31: 121-125.
ComfortMAX™ is a breakthrough supplement that promotes nerve
health and comfort. By inhibiting inflammatory compounds in
your nerve cells and encouraging healthy neurotransmitter
levels in your brain, ComfortMAX™ helps to reduce
discomfort. Take one convenient tablet in the morning and
one at night. Live comfortably with ComfortMAX™!
Benefits at a Glance:
ComfortMAX™ provides dual-action nerve support to help
PEA inhibits inflammatory factors to help calm excited
Honokiol extract supports GABA neurotransmitters
affected by discomfort
These combined actions help you stay comfortable
throughout the day
Morning and nighttime dosing for around-the-clock
ComfortMAX™ delivers two breakthrough ingredients:
palmitoylethanolamide or PEA and honokiol, a compound
derived from Magnolia bark. By promoting nerve comfort in
two separate yet complementary ways, the ingredients in
ComfortMAX™ represent a revolutionary step in maintaining
calm, healthy nerves.Try
According to the National Institutes of Health, nearly 25
million Americans experience daily discomfort.This
kind of discomfort can affect mood, mobility, and quality of
reasons for physical discomfort vary, but the way we
experience that discomfort doesn't: Our peripheral nerves
are responsible for delivering sensory information (an itch,
temperature change, physical pressure, etc.) to the brain.
And that's where ComfortMAX™ comes in.
Palmitoylethanolamide (or PEA) is a unique kind of fatty
acid. Your body naturally produces PEA as part of a healthy
inflammatory and immune response.In
fact, PEA inhibits the secretion of inflammatory compounds
from mast cells, a type of white blood cell. As we age, our
number of mast cells decrease, causing our remaining mast
cells to work harder. That can make them overly sensitive,
activating inflammatory processes linked to nerve
discomfort. By inhibiting inflammatory compounds released by
promotes your body's natural response to uncomfortable nerve
stimuli at the cellular level.9
In a randomized controlled trial following 636 patients over
a period of three weeks, 600 mg of PEA every day profoundly
affected scores that measured relative comfort and quality
a smaller randomized controlled trial, patients reported
that PEA outperformed standard care for discomfort when
taken for two weeks.11
Honokiol is a naturally occurring lignan compound derived
from several species of magnolia, several of which have been
used in traditional Asian medicine for centuries.12,13Now,
scientists are discovering that honokiol has applications
for nerve health and comfort.
Honokiol has been shown to support the "calming" GABA
receptors in the brain,14,15which
affects the way the brain perceives discomfort.16Furthermore,
honokiol is quickly taken up into the brain in animal
it an ideal ingredient for nerve health and comfort.
Unique Daytime & Nighttime Formula
ComfortMAX™ has been formulated to be taken twice a day, one
tablet in the morning and one tablet at night right before
bed, for lasting comfort and nerve health support. Each
package of ComfortMAX™ provides a 30 day supply. Try
Journal of natural products.
journal of pain: official journal of the American Pain Society.
Journal of pain research. 2016;9:457-467.
CNS & neurological disorders drug targets.
European journal of pharmacology. 1996;300(3):227-236.
Brain Behav Immun. 2011;25(6):1099-1112.
CNS & neurological disorders drug targets.
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