GABA Calm Mind by Source Naturals & ComfortMAX by Life Extension
In addition to vitamin B6, magnesium and dimethylglycine (DMG) may result in an appearance of speech in formerly non-speaking autistic children. Magnesium, vitamin B6 and dimethylglycine (DMG) all have strong anti-seizure properties and may be effective in this regard.(5) The deficiency of another member of the B-complex, B1, has also been reported as a contributor to epileptic seizures.(6)
British researchers have found that the age-related decline in higher brain functions is due, in large part, to a lack of the inhibitory neurotransmitter, GABA. Higher brain functions, such as visual recognition and language comprehension, decline as people get older. This decline appears to be due to a reduction of GABA, which results in neurons with specific tasks being more easily fired by some other types of stimulus, slowing down processing of information in the brain.
As people age, brain neurons increasingly fire non-selectively, and interpreting information then becomes like listening to whispering in the discotheque as opposed to shouting in a quiet room.
The new research shows that GABA works as a gating mechanism to help neurons remain selective when responding to stimuli to enable the brain to make sense of the vast quantity of incoming information.
Another consideration for increasing GABA levels is via the amino acid L-glutamine. The glutamine cycle in the brain is simple and elegant. Glutamine readily crosses the blood-brain barrier. Neurons take up glutamine and convert it to glutamate or GABA (through the additional step of decarboxylating glutamate). After either glutamate or GABA are released into the synaptic junction, the supportive cells called glia take up the glutamate or GABA and re-synthesize glutamine -- detoxifying ammonia in the process. The glutamate that is not converted to l-glutamine is used by the glia as a source of energy and also to produce energy nutrients alanine and alpha-ketoglutarate which are then released to the neurons.
This product contains NO sugar, yeast, wheat, gluten, corn, soy or dairy. Contains NO artificial color, sweeteners, flavors or preservatives.
Dosage and Use: 1 capsule daily.
for GABA above:
ComfortMAX™ is a breakthrough supplement that promotes nerve health and comfort. By inhibiting inflammatory compounds in your nerve cells and encouraging healthy neurotransmitter levels in your brain, ComfortMAX™ helps to reduce discomfort. Take one convenient tablet in the morning and one at night. Live comfortably with ComfortMAX™!
Benefits at a Glance:
ComfortMAX™ delivers two breakthrough ingredients: palmitoylethanolamide or PEA and honokiol, a compound derived from Magnolia bark. By promoting nerve comfort in two separate yet complementary ways, the ingredients in ComfortMAX™ represent a revolutionary step in maintaining calm, healthy nerves.Try ComfortMAX™ today!
According to the National Institutes of Health, nearly 25 million Americans experience daily discomfort.This kind of discomfort can affect mood, mobility, and quality of life.The reasons for physical discomfort vary, but the way we experience that discomfort doesn't: Our peripheral nerves are responsible for delivering sensory information (an itch, temperature change, physical pressure, etc.) to the brain. And that's where ComfortMAX™ comes in.
Palmitoylethanolamide (or PEA) is a unique kind of fatty acid. Your body naturally produces PEA as part of a healthy inflammatory and immune response.In fact, PEA inhibits the secretion of inflammatory compounds from mast cells, a type of white blood cell. As we age, our number of mast cells decrease, causing our remaining mast cells to work harder. That can make them overly sensitive, activating inflammatory processes linked to nerve discomfort. By inhibiting inflammatory compounds released by mast cells,6-8 PEA promotes your body's natural response to uncomfortable nerve stimuli at the cellular level.9
In a randomized controlled trial following 636 patients over a period of three weeks, 600 mg of PEA every day profoundly affected scores that measured relative comfort and quality of life.10 In a smaller randomized controlled trial, patients reported that PEA outperformed standard care for discomfort when taken for two weeks.11
Honokiol is a naturally occurring lignan compound derived from several species of magnolia, several of which have been used in traditional Asian medicine for centuries.12,13 Now, scientists are discovering that honokiol has applications for nerve health and comfort.
Honokiol has been shown to support the "calming" GABA receptors in the brain,14,15 which affects the way the brain perceives discomfort.16 Furthermore, honokiol is quickly taken up into the brain in animal models,17-19 making it an ideal ingredient for nerve health and comfort.
Unique Daytime & Nighttime Formula
ComfortMAX™ has been formulated to be taken twice a day, one tablet in the morning and one tablet at night right before bed, for lasting comfort and nerve health support. Each package of ComfortMAX™ provides a 30 day supply. Try ComfortMAX™ today!
References for ComfortMAX
DMAE / Ginkgo
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