GABA Calm Mind by Source Naturals & ComfortMAX by Life Extension - Side Effects, Dose

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GABA Calm Mind by Source Naturals & ComfortMAX by Life Extension

GABA (gamma-amino butyric acid) is an inhibitory neurotransmitter, helping neurons stay selective about the signals to which they respond and helping produce a state of relaxation.  Taken at bedtime, supplemental GABA may assist some people in the initiation of sleep and produce a deeper and more beneficial sleep.

Gamma-amino butyric acid (GABA), the brains major inhibitory neurotransmitter, tends to be in lower than normal levels in seizure-prone rats (1) and humans with epilepsy.(2)  Seizure-prone preeclamptic patients (hypertensive condition during late pregnancy) also have decreased brain GABA concentrations.(3)  Brain GABA levels depend on both zinc and vitamin B6.  Zinc is involved in the maintenance of pyridoxal phosphate (a form of vitamin B6) concentrations by the activation of pyridoxal kinase (enzyme participates in vitamin B6 metabolism).  Pyridoxal kinase is important in decarboxylation, and lack of this enzyme results in lowered brain levels of GABA.  Consequently, zinc deficiency may increase the risk of pre-eclamptic seizures by reducing brain GABA concentrations and lowering the seizure threshold.  Unfortunately, plasma pyridoxal phosphate measurements alone do not appear to accurately reflect vitamin B6 status or true tissue pyridoxal phosphate levels.(3)

In addition to vitamin B6, magnesium and dimethylglycine (DMG) may result in an appearance of speech in formerly non-speaking autistic children.  Magnesium, vitamin B6 and dimethylglycine (DMG) all have strong anti-seizure properties and may be effective in this regard.(5)  The deficiency of another member of the B-complex, B1, has also been reported as a contributor to epileptic seizures.(6)

British researchers have found that the age-related decline in higher brain functions is due, in large part, to a lack of the inhibitory neurotransmitter, GABA.  Higher brain functions, such as visual recognition and language comprehension, decline as people get older.  This decline appears to be due to a reduction of GABA, which results in neurons with specific tasks being more easily fired by some other types of stimulus, slowing down processing of information in the brain.

As people age, brain neurons increasingly fire non-selectively, and interpreting information then becomes like listening to whispering in the discotheque as opposed to shouting in a quiet room.  The new research shows that GABA works as a gating mechanism to help neurons remain selective when responding to stimuli to enable the brain to make sense of the vast quantity of incoming information.

When old Macaque monkeys, equivalent to 90-year-old humans, were treated with GABA and drugs that increase GABA levels in the brain, their performance on tests for brain functions improved vastly within a couple of minutes.  The fact is, all the cells are still there and functioning -- it is a transmitter problem -- its treatable.  While doctors have observed the paradoxical effect of GABA-enhancing drugs making people more alert, this is the first study to show that increasing GABA or its effects may support mental function.

Another consideration for increasing GABA levels is via the amino acid L-glutamine The glutamine cycle in the brain is simple and elegant.  Glutamine readily crosses the blood-brain barrier.  Neurons take up glutamine and convert it to glutamate or GABA (through the additional step of decarboxylating glutamate).  After either glutamate or GABA are released into the synaptic junction, the supportive cells called glia take up the glutamate or GABA and re-synthesize glutamine -- detoxifying ammonia in the process. The glutamate that is not converted to l-glutamine is used by the glia as a source of energy and also to produce energy nutrients alanine and alpha-ketoglutarate which are then released to the neurons.

Supplement Facts for GABA Calm Mind by Source Naturals 90 or 270 capsules.

Each Capsule
GABA (gamma amino butyric acid)

750 mg

Other ingredients: gelatin (capsule), silica, and magnesium stearate.  Hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.  

This product contains NO sugar, yeast, wheat, gluten, corn, soy or dairy. Contains NO artificial color, sweeteners, flavors or preservatives.

Dosage and Use: 1 capsule daily.

References for GABA above:
1. Lasley, S. M. Role of Neurotransmitter Amino Acids in Seizure Severity and Experience in the Genetically Epilepsy-Prone Rat. Brain Res, 1991; 560:63-70
2. During, M.J. and Spencer, D. D. Extracellular Hippocampal Glutamate and Spontaneous Seizure in the Conscious Human Brain. The Lancet, June 26, 1993; 341 (8861): 1607-1610
3. Anonymous. Zinc, Preeclampsia, and Gamma-Aminobutyric Acid. Am Jnl of Obst & Gyn, July 1990, 163, 1, (Part I): 242-243
4. Baumeister, F. Glutamate in Pyridoxine-Dependent Epilepsy: Neurotoxic Glutamate Concentration in the Cerebrospinal Fluid and Its Normalization by Pyridoxine. Ped, September 1994, 94 (3): 318-321
5. Seizures, Vitamin B6, DMG, and Sudden Speech Autism, Res Rev Intl, 1996, 10 (2): 1
6. Keyser, A. Epileptic Manifestations and Vitamin B1 Deficiency. Eur Neuro, 1991, 31: 121-125.


ComfortMAX™ is a breakthrough supplement that promotes nerve health and comfort. By inhibiting inflammatory compounds in your nerve cells and encouraging healthy neurotransmitter levels in your brain, ComfortMAX™ helps to reduce discomfort. Take one convenient tablet in the morning and one at night. Live comfortably with ComfortMAX™!

Benefits at a Glance:

  • ComfortMAX™ provides dual-action nerve support to help inhibit discomfort
  • PEA inhibits inflammatory factors to help calm excited nerves
  • Honokiol extract supports GABA neurotransmitters affected by discomfort
  • These combined actions help you stay comfortable throughout the day
  • Morning and nighttime dosing for around-the-clock support

ComfortMAX™ delivers two breakthrough ingredients: palmitoylethanolamide or PEA and honokiol, a compound derived from Magnolia bark. By promoting nerve comfort in two separate yet complementary ways, the ingredients in ComfortMAX™ represent a revolutionary step in maintaining calm, healthy nerves.Try ComfortMAX™ today!

According to the National Institutes of Health, nearly 25 million Americans experience daily discomfort.This kind of discomfort can affect mood, mobility, and quality of life.The reasons for physical discomfort vary, but the way we experience that discomfort doesn't: Our peripheral nerves are responsible for delivering sensory information (an itch, temperature change, physical pressure, etc.) to the brain. And that's where ComfortMAX™ comes in.

Palmitoylethanolamide (PEA)

Palmitoylethanolamide (or PEA) is a unique kind of fatty acid. Your body naturally produces PEA as part of a healthy inflammatory and immune response.In fact, PEA inhibits the secretion of inflammatory compounds from mast cells, a type of white blood cell. As we age, our number of mast cells decrease, causing our remaining mast cells to work harder. That can make them overly sensitive, activating inflammatory processes linked to nerve discomfort. By inhibiting inflammatory compounds released by mast cells,6-8 PEA promotes your body's natural response to uncomfortable nerve stimuli at the cellular level.9

In a randomized controlled trial following 636 patients over a period of three weeks, 600 mg of PEA every day profoundly affected scores that measured relative comfort and quality of life.10 In a smaller randomized controlled trial, patients reported that PEA outperformed standard care for discomfort when taken for two weeks.11


Honokiol is a naturally occurring lignan compound derived from several species of magnolia, several of which have been used in traditional Asian medicine for centuries.12,13 Now, scientists are discovering that honokiol has applications for nerve health and comfort.

Honokiol has been shown to support the "calming" GABA receptors in the brain,14,15 which affects the way the brain perceives discomfort.16 Furthermore, honokiol is quickly taken up into the brain in animal models,17-19 making it an ideal ingredient for nerve health and comfort.

Unique Daytime & Nighttime Formula

ComfortMAX™ has been formulated to be taken twice a day, one tablet in the morning and one tablet at night right before bed, for lasting comfort and nerve health support. Each package of ComfortMAX™ provides a 30 day supply. Try ComfortMAX™ today!

References for ComfortMAX

  1. Journal of natural products. 1998;61(1):135-138.
  2. Pain physician. 2016;19(2):11-24.
  3. journal of pain: official journal of the American Pain Society. 2015;16(8):769-780.
  4. Journal of pain research. 2016;9:457-467.
  5. CNS & neurological disorders drug targets. 2013;12(1):78-83.
  6. European journal of pharmacology. 1996;300(3):227-236.
  7. Brain Behav Immun. 2011;25(6):1099-1112.
  8. CNS & neurological disorders drug targets. 2013;12(1):34-44.
  9. in Neurosciences. 1996;19(11):514-520.
  10. Dolor. Investigación Clínica & Terapéutica. Vol 252010:35-42.
  11. Journal of orofacial pain. 2012;26(2):99-104.
  12. The Journal of pharmacy and pharmacology. 1998;50(7):819-826.
  13. The Journal of pharmacy and pharmacology. 2000;52(11):1425-1429.
  14. Neuropharmacology. 2012;62(8):2507-2514.
  15. Neurochemical research. 1999;24(12):1593-1602.
  16. Science (New York, NY). 2000;288(5472):1765-1768.
  17. PloS one. 2011;6(4):e18490.
  18. European journal of drug metabolism and pharmacokinetics. 2016;41(5):587-594.

Supplement Facts for ComfortMAX by Life Extension.  30 AM vegetarian tablets.
Serving Size - 1 AM vegetarian tablet (white) Amount Per Serving

Calcium (as calcium carbonate)

60 mg

Palmitoylethanolamide (PEA)

600 mg

Other ingredients: microcrystalline cellulose, croscarmellose sodium, hydroxypropyl methylcellulose, stearic acid, vegetable stearate, silica, maltodextrin, hydroxypropyl cellulose, glycerin.

Supplement Facts for ComfortMAX. 30 PM vegetarian tablets

Serving Size - 1 PM vegetarian tablet (blue)

Amount Per Serving

Calcium (as calcium carbonate)

30 mg

Palmitoylethanolamide (PEA)

600 mg

Honokiol [from magnolia extract (bark)]

180 mg

Other ingredients: croscarmellose sodium, microcrystalline cellulose, hydroxypropyl methylcellulose, stearic acid, hydroypropyl cellulose, vegetable stearate, silica, maltodextrin, spirulina extract color, glycerin.


Dosage and Use
  • Take one (1) AM tablet in the morning and one (1) PM tablet before bed, with or without food, or as recommended by a healthcare practitioner.

The blue PM tablet may cause mild sedation in some people. Take at bedtime.

  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

 Order:   GABA and ComfortMAX | DMAE / Ginkgo Biloba, Acetyl-L-Carnitine, Extension IQ, Vinpocetine, Cognitex | CoQ-10 | Lithium Orotate |
TMG | Life Extension Herbal Mix (contains chlorella)

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