Grape Seed Skin Extract w/Resveratrol (Proanthocyanidins) - Side Effects Free, Benefits - Dose by Life Extension

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Grape Seed Skin Extract w/Resveratrol (Proanthocyanidins) by Life Extension

GrapeSeed Extract w/Resveratrol - 100 mg, 60 capsules (these are also ingredients in Life Extension Mix)

Grape Seed Extract is a concentration of the pure oligomeric proanthocyanidins found in grape seeds and skins.  The extraction method used to obtain Grape Seed Extract also ensures that it is free from solvent residues contributing to its side effects free status.  Grape Seed  Extract contains powerful, natural, bioflavonoid complexes, which are rapidly absorbed and distributed throughout the body.  In vitro, the antioxidant power of Grape Seed Extract is 50 times greater than vitamin E and 20 times greater than vitamin C.

Unlike other products on the market that contain only oligomeric proanthocyanidins, Grapeseed Extract with Resveratrol contains standardized levels of resveratrol, an extract that comes from grapes, vines and other plants without side effects.  Whole grape extracts contain a spectrum of polyphenols that are naturally contained in red wine such as proanthocyandins, anthocyanins, and flavonoids, that have been found by researchers to possess certain properties important in maintaining optimal health free from side effects.

This blend also provides standardized resveratrol, the polyphenol in red wine that has shown so many health benefits and the plant extract pterostilbene, which researchers have found works synergistically with resveratrol to activate ones longevity genes.

Pycnogenol is the name of a group of compounds that contain proanthocyanidins taken from a number of natural sources such as grape seeds and other plants including the French maritime pine tree (Pinus maritima).

The ingredients in Grape Seed Extract show that they:

  • Work with glutathione to restore oxidized vitamin C,
  • Bind to collagen fibers, tendons, and ligaments supporting strength,
  • Are very stable on the shelf, showing no loss of potency after 12 years of storage.

Supplement Facts:
Serving Size - 1 cap.  Servings / Container - 60. 
Amount / Serving

Vitamin C (as calcium ascorbate)

250 mg

Calcium (as calcium ascorbate)

25 mg

Proprietary Blend:

Oligomeric Proanthocyanidins (from Masquelliers OPC grape seed extract) (Vitis vinifera) {98% average content of polyphenolic compounds, procyanidolic value 90%}.  Typical profile: (to equal 98% average content of polyphenolic compounds)

100 mg

Resveratrol [from whole red grape (Vitis vinifera) and Polygonum cuspidatum (root) extract]

20 mg



OPC-precursors (catechin, epicatechin)


Gallic acid


Trans-Pterostilbene (as pure Pterospan and SMART pterostilbene)

0.125 mg

Leucoselect Grapeseed extract (Vitis vinifera) (standardized for 95% proanthocyanidins)

Other ingredients:  Rice flour, vegetable cellulose (capsule), vegetable stearate.  This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.

Before we look at some of these benefits, a quick note on the often confusing current terminology.  Different authors use different terms.  Proanthocyanidins, being short chains of catechin subunits, are also called oligomeric condensed tannins and are occasionally referred to as oligomeric proanthocyanidin complexes, or OPCs.  Anthocyanins, which are larger molecules, are sometimes called polymeric condensed tannins.  Both types of compounds, often referred to by the general term such as polyphenols, polyphenolics, or flavonoids, or even simply plant pigments, are widely distributed in plants, including peel, seeds, flowers and bark.  Various berries, dark grapes and pine bark are particularly rich sources of proanthocyanidins and anthocyanins.  Plants usually contain complex mixtures of phenolic compounds, including simple phenolic acids, quercetin, catechins, epicatechins, proanthocyanidins and anthocyanins.  Wine is estimated to contain over two hundred phenolic compounds, though it is known that proanthocyanidins are the major polyphenols.

Anthocyanins are a separate class of flavonoids from proanthocyanidins, discussed in NSN 2000;5(6):231-4.  Anthocyanins are the active component in several herbal folk medicines such as bilberry (Vaccinium myrtillus), which was used in the 12th century.  Scientists are now discovering how such anthocyanins work and are beginning to appreciate their health benefits and positive side effects.  Besides chlorophyll, anthocyanins are probably the most important group of visible plant pigments.  Approximately 4,000 different flavonoids have been identified.  We now have excellent extracts that provide standardized doses of the active polyphenols in berries and grapes.  Bilberry extract and grape seed extract are the best known; cranberry extract and elderberry extract are also available for special uses.

One of the most important properties of anthocyanins and simpler phenolic compounds such as ellagic acid and quercetin is their ability to recycle glutathione.  Glutathione is one of our most important antioxidant defenses.  It is a tri-peptide consisting of amino acids glutamate, glycine and cysteine.  Alpha lipoic acid and n-acetyl-cysteine also raise glutathione.  If you wish to take oral glutathione, it might be a good idea to take a high dose of bilberry extract with the glutathione capsule in order to help prevent glutathione from being oxidized right in the gastro-intenstinal tract.

So, it may be wise to consume plenty of berries, cherries and plums and a moderate amount of red wine -- the richest natural sources of proanthocyanidins, anthocyanins, simple phenolic acids and other phenolic compounds.  And, to initiate or continue a standard regimen.  Since even blueberries can get boring when eaten every day, it is good to try all kinds of berries and other antioxidant-rich fruit in order to enjoy variety.  Blackberries, for instance, are also an extremely rich source of phenolic.  Likewise, tart cherries, now available in the dried form, are a delicious source of anthocyanins and ellagic acid.  Unsweetened prunes are also high on the list of antioxidant-rich fruit.  Think in terms of rich, deep pigments and somewhat tart taste -- these signal the presence of the beneficial polyphenols without side effects.

In order to get the full benefits of blueberries and/or bilberry extract, you should eat an adequate amount and/or take an adequate dose.  Half a cup of blueberries a day is probably the minimum needed to provide benefits;  a whole cup may work better for optimum health.  The elderly may also consider consuming a larger amount, or else supplement their berry consumption with high-potency bilberry extract.  You may want to experiment to see what dosage range works best for you.  You might also consider taking 300 mg of grape seed extract at bedtime.  However, you can adjust the dose according to your age, body size and other antioxidants currently taken.

The general rule to create positive effects is that a synergistic mixture of antioxidants works much better than relying on a single agent.

In summary, getting sufficient doses of polyphenols/
proanthocyanidins from diet and supplements should be an important part of any serious health regimen.

Dosage and Use:  One to two capsules daily with or without food are suggested.

  • Keep out of reach of children,
  • Do not exceed recommended dose,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using Grape seed skin extract (proanthocyanidin pills), please inform your physician.

More Grape Seed Skin Information

Pricing Information:  Grape Seed Skin Extract w/Resveratrol | Resveratrol (straight) | References


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