Green Coffee Side Effects of Extract= Weight Loss, Less Body Fat, Glucose Control - Page 2
As seen on the Dr. Oz Show

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Green Coffee Side Effects= Glucose Control, Chlorogenic Acid for Body Fat Weight Loss - Page 2
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Green Coffee Bean Extract Inhibits Calories and Glucose Absorption! - Page 2
As seen on the Dr. Oz Show
Reprinted by permission from Bill Faloon of The Life Extension Foundation - By Michael Downey

To investigate the weight-reducing positive side effects that had been shown in roasted and brewed coffee, scientists turned to compounds extracted directly from green coffee beans.  The green coffee beans contain higher amounts of chlorogenic acid and other polyphenol compounds that are substantially lost during the roasting process that turns them brown.

Investigators tested two agents on mice:  Chlorogenic acid, a key green coffee bean compound and green coffee bean extract.  They found that chlorogenic acid alone showed a moderate weight-reducing effect.  However, the green coffee bean extract produced greater weight loss.13  This was attributed to its ability to inhibit the absorption of fats from the intestine and enhance fat metabolism in the liver.13

Further testing involved mice that were administered a high-fat diet (37% calories from fat) causing obesity which helped confirm these findings.16

In other research with mice, coffee polyphenols enhanced energy metabolism, decreased lipogenesis (the formation of fat) and inhibited weight gain.  The researchers found a suppression of body fat which resulted from a downregulating of sterol regulatory element-binding protein and related molecules.14

Encouraged by the anti-obesity positive side effects of these extracts in animals, scientists designed new experiments to confirm that green coffee bean extract would significantly decrease body fat in humans.

In a 12-week, placebo-controlled study, scientists tested the efficacy of green coffee bean extract.  Thirty overweight or obese human volunteers took either the extract or a placebo, dissolved in instant coffee.  The extract produced an average 11 pound weight loss.  This was paralleled by a decrease in glucose absorption and an increase in glucose utilization.  The researchers reported that the lower availability of glucose that results from these side effects would cause the body to increase the metabolism of fat reserves, which would eventually decrease body fat and mass.17

By this point, scientists had accumulated substantial evidence that both caffeinated and decaffeinated coffee and especially, green coffee bean extract significantly reduce the absorption of glucose,17,19,21 and the absorption of fats.13,16  There was also evidence of a decrease in the enzyme amylase,10 which would reduce the absorption of carbohydrates.  These positive effects indicated that green coffee bean extract decreases absorption of calories and produces substantial weight loss.17

A 2011 review and meta-analysis of published and unpublished human studies involving randomized clinical trials using green coffee bean extract in doses of 180 mg to 200 mg daily concluded that there was an overall decrease in body weight.  However, the scientists concluded that further rigorous research was needed to conclusively establish the weight-loss efficacy of the extract.42

Compelling Weight-Loss Results
To determine conclusively that green coffee bean extract has a potent anti-obesity benefit, scientists set up a study of rigorous design -- a randomized, double-blind, placebo-controlled, linear dose, crossover study on humans.

In a crossover study, participants are cycled through different phases of treatment and placebo.  In this case, subjects took a high dose of green coffee bean extract for 6 weeks, a lower dose green coffee bean extract for 6 weeks, and a placebo for 6 weeks in a randomized, double-blind manner.  Between phases, there was a 2-week washout period, making the entire study 22 weeks long.

Crossover studies are considered sound because each person in the test group serves as his or her own control.  This improves the chances of getting an accurate result, because it eliminates the possibility of the outcome reflecting a difference between the active and control groups.  Instead, any difference in results can be attributed with much greater confidence to the different supplements taken.

To ensure the findings were more representative, the investigation enlisted both men and women.

Participants were restricted to those who were classified by their BMI as obese or pre-obese because those who have these conditions are subject to obesity's negative metabolic side effects and find weight loss difficult to achieve.

To avoid any confounding effect from drugs, subjects were excluded if they had taken any medications known to influence weight during the previous 6 months.

To further ensure that any effect on weight, body fat or BMI could be solely attributed to the extract, there were no significant changes in dietary calories or in the dietary percentages of carbohydrates, fat, and proteins at any time during the study.  There were also no significant changes in exercise.  The daily capsules were the only intervention, although in a non-study situation, people seeking weight reduction would ideally combine this intervention with lower calorie consumption and greater physical activity to promote maximum weight loss.

During the high-dose phase, subjects took 350 mg of extract, three times daily.  The lower dose phase included 350 mg of extract, taken twice daily. The placebo phase involved a 350 mg dose three times daily of an inert capsule containing an inactive substance.

In January 2012, the Scientists Reported the Striking Results
Although there were no changes in calorie intake or exercise over the 22-week trial, the investigators found that all subjects experienced an impressive reduction in body weight, BMI, and body fat during both the high-dose and low-dose phases of the study, but not in the placebo phase!  After just 12 weeks of administering 350 mg green coffee bean extract three times a day over the course of the 22-week study, the scientists found that:28

  • Weight decreased by over 17.6 pounds on average with some subjects losing more than 22.7 pounds!
  • BMI decreased by an average of 2.92!
  • Body fat decreased by an average 4.44%, with some subjects losing 6.44% of their body fat!
  • Heart rate decreased by a significant average of 2.56 beats per minute!

The substantial anti-obesity impact was clearly reflected in the positive side effects findings that a remarkable 37% of participants who were assessed as having pre-obesity (25-30 BMI) at the start of the study had their condition reversed to the normal-weight range!28

A study follow-up showed that, contrasting with food-restriction diets, a surprising 87.5% of the test subjects were able to maintain their weight loss after completing the study.28  No negative side effects were observed.

Exploring the Biochemical Mechanisms
Research into exactly how green coffee bean extract produces its dramatic pound-shedding effect is in its early stages.  However, existing evidence indicates that this powerful coffee extract has the ability to safely decrease the intestinal uptake of glucose, fats, and carbohydrates and reduce the negative side effects of the absorption of calories!  Research shows that it also interferes with glucose transport and the production and storage of fats while promoting utilization of glucose and breakdown of body fat.  Scientists speculate that its multiple biochemical mechanisms may work to:

  • Inhibit the enzyme amylase, which would decrease the gastrointestinal tract absorption of sugar and calories10
  • Interfere with glucose-6-phosphatase, an enzyme involved in creation of often surplus blood glucose from protein and fats19
  • Suppress accumulation of hepatic triglycerides13
  • Alter body-fat distribution16
  • Downregulate fatty acid and cholesterol biosynthesis16
  • Upregulate fatty acid oxidation and expression of peroxisome proliferator-activated receptor alpha (PPAR-alpha) -- a key regulator of lipids and glucose15,16
  • Interfere with glucose transport21
  • Inhibit pancreatic lipase -- an enzyme that breaks down fats in the digestive tract11
  • Retard absorption of fats from the intestine, and activate fat metabolism in the liver13
  • Enhance energy metabolism14
  • Reduce lipogenesis and fat accumulation by downregulating sterol regulatory element-binding protein and similar molecules14
  • Inhibit the enzyme alpha-glucosidase, which breaks apart complex sugars and enhances their absorption into the blood43
  • Increase the signal protein for insulin receptors in liver cells, increasing insulin sensitivity and decreasing glucose levels22
  • Antagonize glucose uptake in the proximal small intestine, shifting absorption to more distal regions of the small intestine, thus reducing overall glucose uptake21
  • Promote synthesis of the homeodomain transcription factor IDX-1, which helps the insulin-regulating beta cells respond to the positive side effects of increases in plasma glucose24
  • Promote dispersal of the sodium ion (Na+) electrochemical gradient, in turn reducing glucose absorption27
  • Enhance whole-body metabolism, as shown by greater oxygen consumption14

Whatever the mechanism through which green coffee bean extract delivers its beneficial effects, it has been shown to have a unique anti-obesity benefit:  It substantially reduces body weight and body fat -- even without a change in exercise or calorie consumption!28

Summary
Obesity increases the risk of chronic diseases and puts its victims at a 200-300% greater risk of death.3,4

The good news is that scientists have found that green coffee bean extract can intervene in a unique way to inhibit the process behind obesity.  Its compounds can reduce levels of fat11-16 and glucose14,15,17-27 in the body and can decrease the absorption of calories!10

In a recent, placebo-controlled study on humans, green coffee bean extract decreased weight by a remarkable average of over 17.6 pounds!28  And, 37% of participants reversed their pre-obesity status back to the normal-weight range!28  These results confirm that green coffee bean extract is a unique and potent intervention to alter obesity in a positive direction.

Warnings Information:

  • Keep green coffee beans for weight loss out of reach of children,
  • Do not exceed recommended dose,
  • If you have any kind of negative side effects, discontinue use immediately,
  • When using green coffee, please inform your physician,
  • Results may vary from person to person concerning weight loss or blood glucose control.
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