Triple-Action Cruciferous Vegetable Extract with Cat's Claw
60 Vegetarian Capsules
Most aging people (men and women, both) are in
estrogen overload. With the dangers associated with excess estrogen,
I3C acts like an estrogen vacuum cleaner.
The process begins when I3C is
ingested. Stomach acid converts it into a variety of products that
ultimately induce the enzyme cytochrome P450, which signals the body to
metabolize estrogen via the 2-hydroxylation pathway. By funneling
estrogen into this pathway, I3C essentially
"vacuums" away the estrogen.10
Scientists have identified specific
extracts from cruciferous vegetables (broccoli, cauliflower,
Brussels sprouts, etc.) that modulate hormones in a way to help
maintain healthy cell division. For instance, animal studies have
shown that the cruciferous vegetable extract
estrogen hormones by favorably changing the ratio
of protective 2-hydroxyestrone versus the damaging
16-hydroxyestrone.1 Indole-3-carbinol also induces phase I and II detoxifying enzymes
that can help neutralize estrogen metabolites and xenobiotic
estrogen-like environmental chemicals.2
Human studies support the beneficial role of I3C in positively
altering estrogen metabolism.3
Di-indolyl-methane (DIM), a phytonutrient found in cruciferous
vegetables, has been shown in animal studies to help maintain
normal levels of a potentially damaging estrogen called
The glucosinolates are major
constituents of cruciferous vegetables that have been shown to
promote normal apoptosis and induce the expression of the
beneficial p53 gene via an estrogen-independent action.5
Watercress contains isothiocyanates,
but in a broader spectrum than does broccoli. The primary
isothiocyanate precursor (PEiTC) in watercress functions via four
specific mechanisms to maintain healthy cell division.6
Extracts from rosemary enhance liver metabolism of estradiol and
estrone,7 inhibits the
formation of DNA adducts,8
and have been shown to impede estrogen-induced growth promotion in
Cats Claw, the Amazonian wonder
herb, also known as Uncaria tomentosa or Ua de Gato,
has been available for years, but there are various qualities of
extracts. Dual-Action Cruciferous Vegetable products contain only
Cats Claw water extract which has naturally occurring potent
compounds called carboxy alkyl esters. These compounds, not found
in typical Cats Claw products, have properties of DNA repair
and anti-inflammation, and immune stimulation. Cat's claw protects
cells against oxidative stress and inhibits lipopolysaccharide-induced
iNOS gene expression, nitrite formation, cell death and inhibited
the activation of NF-kappaB.9
The Cats Claw water extract
material is produced through a patented aqueous extraction process
which also removes tetracyclic oxindole alkaloids (TOA). TOA
inhibit the activity of the other active compounds in Cats
Claw, so it was highest priority to find a TOA-free Cats Claw
to deliver maximum benefit.
Apigenin, a powerful plant flavonoid
found in plants such as parsley and celery, is also added to the
formula to boost cell protection, while 25 milligrams of cabbage extract, a natural source of
benzyl isothiocyanate (BITC), are included to maintain cell
The patented extraction process
produces a standardized water soluble extract that can be readily
absorbed by the body.
Supplement Facts: Serving
Size - 1
Per Container - 60.
oleracea l.) Super Concentrate Extract
(plants and sprouts) [std. to 4% glucosinolates
officinale) 4:1 Extract (leaf)
officinalis) Extract (leaves) [std. to 20%
diterpenic compounds (10 mg), providing carnosic
Cat's Claw (Uncaria
tomentosa) Extract (bark) [std. to 8%
carboxy alkyl esters (2 mg)]
Cabbage (Brassica oleracea) extract
Other ingredients: Rice flour,
vegetable capsule, magnesium stearate, silica. Contains corn
and yeast. This product contains NO milk, egg, fish, peanuts,
crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts,
wheat, yeast, or gluten. Contains NO sugar, and no artificial
sweeteners, flavors, colors, or preservatives.
Dosage and Use:
- One capsule daily for
individuals weighing up to 160 pounds,
- Those weighing over 160
pounds, take two capsules daily,
- This product can be taken
with or without food.
May interfere with oral
contraceptives. If pregnant or intending to become pregnant,
do not use this product. Do not use if taking antacids, H2-receptor
blockers (e.g. Zantac ), or proton-pump inhibitors (e.g. Nexium),
as these drugs may impede the conversion of I3C to active
This product is not intended to treat, cure,
prevent or diagnose any disease.
- Keep Indole-3-Carbinol (I3C)
extract out of reach of children,
- Do not exceed recommended dose,
- If you have a bad reaction or
discontinue use immediately,
- When using Indole-3-Carbinol (I3C) extract,
please inform your physician.
1. Biochem Pharm. 2002, 64;393-404.
2. Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52.
3. J Natl canc Inst. 1997 May 21;89(10):718-23.
4. canc Detect Prevent. 2004;28:72-9.
5. Carcinogenesis. 2002 Apr;23(4):581-6.
6. Mol canc Ther. 2003 Oct;2(10);1045-52.
7. Carcinogenesis. 1998 Oct;19(10):1821-7.
8. Carcinogenesis. 1995 Sep;16(9):2057-62.
9. Aliment Pharmacol Ther. 1998 Dec;12(12):1279-89
10. Nutr canc. 1991;16 (1): 59-66
Information: Indole-3-Carbinol (I3C)