Indole-3-Carbinol (I3C) with Resveratrol, Extract, Benefits - Dose

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Triple-Action Indole-3-Carbinol (I3C) w/Resveratrol, Cats Claw
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 Triple-Action Cruciferous Vegetable Extract With Indole-3-Carbinol (I3C), 
Resveratrol, & Cat's Claw -- Benefits, Dose --
60 Vegetarian Capsules

Most aging people (men and women, both) are in estrogen overload.  With the dangers associated with excess estrogen, I3C acts like an estrogen vacuum cleaner.

The process begins when I3C is ingested.  Stomach acid converts it into a variety of products that ultimately induce the enzyme cytochrome P450, which signals the body to metabolize estrogen via the 2-hydroxylation pathway.  By funneling estrogen into this pathway, I3C essentially "vacuums" away the estrogen.10

Scientists have identified specific extracts from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, etc.) that modulate hormones in a way to help maintain healthy cell division.  For instance, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone.1

Indole-3-carbinol (I3C) also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals.2  Human studies support the beneficial role of I3C in positively altering estrogen metabolism. Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone.4

The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action.5

Watercress contains isothiocyanates, but in a broader spectrum than does broccoli.  The primary isothiocyanate precursor (PEiTC) in watercress functions via four specific mechanisms to maintain healthy cell division.6  Extracts from rosemary enhance liver metabolism of estradiol and estrone,7 inhibits the formation of DNA adducts,8 and have been shown to impede estrogen-induced growth promotion in certain tissues.7

Cats Claw, the Amazonian wonder herb, also known as Uncaria tomentosa or Ua de Gato, has been available for years, but there are various qualities of extracts.  Triple-Action Cruciferous Vegetable products contain only Cats Claw water extract which has naturally occurring potent compounds called carboxy alkyl esters.  These compounds, not found in typical Cats Claw products, have properties of DNA repair and anti-inflammation, and immune stimulation.  Cat's claw protects cells against oxidative stress and inhibits lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappaB.9

The Cats Claw water extract material is produced through a patented aqueous extraction process which also removes tetracyclic oxindole alkaloids (TOA).  TOA inhibit the activity of the other active compounds in Cats Claw, so it was highest priority to find a TOA-free Cats Claw to deliver maximum benefit.

The patented extraction process produces a standardized water soluble extract that can be readily absorbed by the body.

Life Extension has combined its cruciferous vegetable complex with a standardized resveratrol extract based on indications from published scientific literature that resveratrol may also be an effective plant extract for maintaining optimal health.

This organic whole-grape extract contains a spectrum of polyphenols naturally found in red wine, such as proanthocyanidins, anthocyanins, and flavonoids.

Apigenin, a powerful plant flavonoid found in plants such as parsley and celery, is also added to the formula to boost cell protection, while 25 milligrams of cabbage extract, a natural source of benzyl isothiocyanate (BITC), are included to maintain cell health.

The patented extraction process produces a standardized water soluble extract that can be readily absorbed by the body.


Supplement Facts: Serving Size - 1 capsule.  Servings Per Container - 60.

Broccoli (Brassica oleracea l.) Super Concentrate Extract (plant and sprouts) [std. to 4% glucosinolates (16 mg)]

400 mg

Watercress (Nasturtium officinale) 4:1 Extract (leaf)

50 mg

Indole-3-Carbinol (I3C)

80 mg

Rosemary (Rosmarinus officinalis) Extract (leaves) [std. to 20% diterpenic compounds (10 mg) and providing carnosic acid/carnosol]

50 mg

Cat's Claw (Uncaria tomentosa) Extract (bark) [std. to 8% carboxy alkyl esters (4 mg)]

50 mg

Trans-resveratrol [also supplying glycosides (polydatin)] [from whole red grape (Vitis vinifera) and Polygonum cuspidatum (root) extract]

20 mg

DIM (Di-indolyl-methane)

14 mg


25 mg

Cabbage (Brassica oleracea) extract (leaf)

25 mg

Other ingredients:  Vegetable cellulose (capsule), vegetable stearate, silica, maltodextrin.  Contains yeast and corn.  This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, gluten, or rice.  Contains NO artificial sweeteners, flavors, colors, or preservatives.

Caution:  May interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product.  Do not use if taking antacids, H2-receptor blockers (e.g. Zantac), or proton pump inhibitors (e.g. Nexium), as these drugs may impede the conversion of I3C to active metabolites.

Dosage and Use:

  • The suggested dose is one capsule daily for individuals weighing up to 160 pounds,
  • For those weighing over 160 pounds, one capsule twice a day is suggested,
  • This product can be taken with or without food.

Warnings Information:
  This product is not intended to treat, cure, prevent or diagnose any disease.

  • Keep out of reach of children,
  • Do not exceed recommended dose,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using Indole-3-Carbinol (I3C) with Resveratrol extract, please inform your physician.

 Order:   Indole-3-Carbinol (I3C) with Resveratrol

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1.  Biochem Pharm. 2002, 64;393-404.
2.  Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52.
3.  J Natl canc Inst. 1997 May 21;89(10):718-23.
4.  canc Detect Prevent. 2004;28:72-9.
5.  Carcinogenesis. 2002 Apr;23(4):581-6.
6.  Mol canc Ther. 2003 Oct;2(10);1045-52.
7.  Carcinogenesis. 1998 Oct;19(10):1821-7.
8.  Carcinogenesis. 1995 Sep;16(9):2057-62.
9.  Aliment Pharmacol Ther. 1998 Dec;12(12):1279-89.

10. Nutr canc. 1991;16 (1): 59-66


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