Inositol (1000mg - hexanicotinate, hexaniacinate) Effects, Benefits - Dose

Welcome To
SmartBodyz Nutrition
Your Online Source for Nutritional Supplements and Related Research

Inositol (1000mg - hexanicotinate, hexaniacinate) - 360 Caps
Home Products
A-K
Products
L-Z
Amazon Shopping Terms and Conditions MX GuardDog Spam Blocker View Cart
Live Search
Buy anything from eBay!


Inositol (1000mg - hexanicotinate, hexaniacinate) Effects, Benefits - Dose

by Life Extension Foundation --
1000 mg, 360 capsules

Inositol is a ubiquitous carbohydrate that is present in large amounts in brain tissue and is involved in neuronal signaling and osmo-regulation.  This sugar is an essential component of the inositol signaling system, which is a post-receptor second messenger signaling system found in many cells.  Myo-inositol is the precursor of membrane inositol phospholipids, which are critically linked to a number of CNS receptor signalling systems, including muscarinic, serotonergic, adrenergic, metabotropic and histaminergic systems, and those linked to cholecystokinin, tachykinins, neurotensin, platelet activating factor and other transmitters.  Upon stimulation of these receptors, a signal is transmitted through a guanosine triphosphate (GTP)-binding protein (G(q)), which then activates the enzyme phospholipase C.  This results in the release of a second messenger, inositol 1,4,5-trisphosphate (InsPinf 3), from membrane inositol phospholipids.  InsPinf 3 then causes the release of free intracellular calcium into the cytosol, activating a number of enzymes or receptors.  Myo-inositol in the brain is derived from 3 sources: (i) receptor stimulation (a salvage pathway); (ii) de novo synthesis from glucose; and (iii) uptake of dietary myo-inositol through plasma membrane myo-inositol transporters.  Most myoinositol is probably derived from the first 2 sources, which are controlled through the lithium-sensitive enzyme myo-inositol monophosphatase (IMPase).  This enzyme acts upon myo-inositol monophosphates, hydrolysing them to release free myo-inositol.
Recent biochemical, molecular and crystallographic studies have demonstrated that the overall metabolism of brain inositol is closely modulated by this enzyme.  Lithium salts, which are commonly used in various psychiatric conditions, inhibit this enzyme, and this action has been implicated as a therapeutic mechanism of action of lithium.  A change in the availability of CNS inositol may lead to altered brain cell signaling pathways and, eventually, to the development of a disorder.  Recent evidence indicates that myo-inositol has psychoactive effects, with initial studies demonstrating effectiveness.  At present, the exact mechanism of these clinical effects is uncertain.  The development of various inositol system-based drugs may lead to future psychoactive drugs designed to modulate a second messenger cascade of events rather than a receptor system, and will lead to further understanding of the CNS from a post-receptor second messenger perspective.

Vadnal R.; Parthasarathy L.; Parthasarathy R.
Dr. R. Vadnal, Mental Hlth./Behavioural Scis. Serv., VA Medical Center, 800 Zorn Avenue, Louisville, KY 40206 United States
CNS Drugs (New Zealand) 1997, 7/1 (6-16)

Supplement Facts:  Serving Size - 1 capsule.  Servings Per Container 360

Amount Per Serving

Inositol hexanicotinate

1000 mg

Other ingredients:  Gelatin and purified water.


Found in muscles, inositol has been found to be essential for calcium and insulin metabolism.

No-Flush Niacin contains a special form of niacin, inositol hexanicotinate, an ester compound formed from a six-to-one (6:1) molecular ratio (4:1 by weight) of niacin and inositol.  Its unique properties allow for true niacin activity without niacin's characteristic flush that some people find bothersome.

Dosage and Use:  One capsule once or twice daily is suggested, or as directed by a healthcare practitioner.  This product is best utilized when taken with meals.

Caution:  High doses of inositol can cause diarrhea in some individuals.

Warnings Information:

  • Keep out of reach of children,
  • Do not exceed recommended dosage,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using inositol supplements, please inform your physician,
  • If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement.

More Information:  Inositol (500mg - hexanicotinate, hexaniacinate) Effects, Benefits, Dose

 Order:   Inositol | No-Flush Niacin (inositol hexanicotinate)

Pay it Forward - Give You and Your Loved Ones the Gift of Health!
Sale - In addition to your 25% off, you get another 10% automatic volume discount at checkout on orders of $25 or more ... all items apply (including special sale items).  SECURE SHOPPING CART CREDIT CARD PURCHASES ONLY.  Call-ins do not receive this special discount.

We Accept All Major Credit Cards or, .
Or , or send a check, money order, or cashiers check with completed order form.

 

Enjoy the benefits of our flat rate shipping and handling!  You receive the same great service for the same shipping price whether you order one item or one hundred!

$5.97 - Within USA only - US Post Office  5-9 business days.

$29.77 - To Canada only (see warning information here) 5-9 business days to customs check point (the only way we ship - US Post Office).

$39.77 - Outside USA only
(see warning here) 7-10 business days to your country's customs check point (the only way we ship - US Post Office).

Save 8.25% on all purchases - Texans and everyone!

It's all tax free!  You will be able to review all charges before they are charged to you.

At checkout (after you click the Add button on any of the order pages), the billing address you enter must match the address where you receive your credit card (security effects).  The shipping address you enter does not have to match.

All orders placed by Noon Central Standard Time (CST) are shipped the same day.  PO Boxes Okay.

Payment by credit card is immediate.  Payment by check adds a few more business days -- as soon as funds clear.

We do not sell the information you give us to anyone.


Protecting Your Personal Information
:
We pledge a safe and worry-free shopping experience using the industry standard for Internet security, 128-bit Secure Sockets Layer (SSL) encryption (see an online payments diagram).  SSL scrambles your personal and credit card information as it travels the Internet during the checkout process.  We utilize the Authorize.Net payment gateway.  Your credit card information is encrypted and sent to an Authorize.Net transaction server.  This server sends the data through the network to the card's bank, using a secure, proprietary connection.  When complete, you will receive an approval or decline response.  At no point is your credit card information stored on our server.

For additional information regarding the privacy of your sensitive cardholder data, please read the Authorize.Net Privacy Policy.

SmartBodyz Nutrition Home Page
1000 West 10th, Suite 218
Fort Worth, Texas 76102
Local Telephone: 817-335-1982
Email: DG[at]SmartBodyz.com - replace [at] with @
(helps prevent spam)
Copyright 1996-2017, SmartBodyz Nutrition -- all rights reserved.

Credit Card Processing

Credit Card Processing

You can shop here with safety and confidence.  We have partnered with Authorize.Net, a leading payment gateway since 1996, to offer safe and secure credit card transactions.

The information and statements made throughout this web site have not been endorsed/evaluated by the Food and Drug Administration or any other governmental authority, unless otherwise specifically noted.  We do not offer products or services for the benefits or purpose of diagnosis, prescription for, treatment of, or claims to prevent, mitigate or cure any viral or disease condition or be free from side effects.  Please, seek the advice of a competent medical professional about anything you read on our site.

BlogBlogLinks | Testimonials | Privacy | RSS Feed