Inositol (1000mg - hexanicotinate, hexaniacinate) Effects, Benefits - Dose

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Inositol (1000mg - hexanicotinate, hexaniacinate) - 360 Caps
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Inositol (1000mg - hexanicotinate, hexaniacinate) Effects, Benefits - Dose
by Life Extension Foundation --
1000 mg, 360 capsules

Inositol is a ubiquitous carbohydrate that is present in large amounts in brain tissue and is involved in neuronal signaling and osmo-regulation.  This sugar is an essential component of the inositol signaling system, which is a post-receptor second messenger signaling system found in many cells.  Myo-inositol is the precursor of membrane inositol phospholipids, which are critically linked to a number of CNS receptor signalling systems, including muscarinic, serotonergic, adrenergic, metabotropic and histaminergic systems, and those linked to cholecystokinin, tachykinins, neurotensin, platelet activating factor and other transmitters.  Upon stimulation of these receptors, a signal is transmitted through a guanosine triphosphate (GTP)-binding protein (G(q)), which then activates the enzyme phospholipase C.  This results in the release of a second messenger, inositol 1,4,5-trisphosphate (InsPinf 3), from membrane inositol phospholipids.  InsPinf 3 then causes the release of free intracellular calcium into the cytosol, activating a number of enzymes or receptors.  Myo-inositol in the brain is derived from 3 sources: (i) receptor stimulation (a salvage pathway); (ii) de novo synthesis from glucose; and (iii) uptake of dietary myo-inositol through plasma membrane myo-inositol transporters.  Most myoinositol is probably derived from the first 2 sources, which are controlled through the lithium-sensitive enzyme myo-inositol monophosphatase (IMPase).  This enzyme acts upon myo-inositol monophosphates, hydrolysing them to release free myo-inositol.
Recent biochemical, molecular and crystallographic studies have demonstrated that the overall metabolism of brain inositol is closely modulated by this enzyme.  Lithium salts, which are commonly used in various psychiatric conditions, inhibit this enzyme, and this action has been implicated as a therapeutic mechanism of action of lithium.  A change in the availability of CNS inositol may lead to altered brain cell signaling pathways and, eventually, to the development of a disorder.  Recent evidence indicates that myo-inositol has psychoactive effects, with initial studies demonstrating effectiveness.  At present, the exact mechanism of these clinical effects is uncertain.  The development of various inositol system-based drugs may lead to future psychoactive drugs designed to modulate a second messenger cascade of events rather than a receptor system, and will lead to further understanding of the CNS from a post-receptor second messenger perspective.

Vadnal R.; Parthasarathy L.; Parthasarathy R.
Dr. R. Vadnal, Mental Hlth./Behavioural Scis. Serv., VA Medical Center, 800 Zorn Avenue, Louisville, KY 40206 United States
CNS Drugs (New Zealand) 1997, 7/1 (6-16)

Supplement Facts:  Serving Size - 1 capsule.  Servings Per Container 360

Amount Per Serving

Inositol hexanicotinate

1000 mg

Other ingredients:  Gelatin and purified water.


Found in muscles, inositol has been found to be essential for calcium and insulin metabolism.

No-Flush Niacin contains a special form of niacin, inositol hexanicotinate, an ester compound formed from a six-to-one (6:1) molecular ratio (4:1 by weight) of niacin and inositol.  Its unique properties allow for true niacin activity without niacin's characteristic flush that some people find bothersome.

Dosage and Use:  One capsule once or twice daily is suggested, or as directed by a healthcare practitioner.  This product is best utilized when taken with meals.

Caution:  High doses of inositol can cause diarrhea in some individuals.

Warnings Information:

  • Keep out of reach of children,
  • Do not exceed recommended dosage,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using inositol supplements, please inform your physician,
  • If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement.

More Information:  Inositol (500mg - hexanicotinate, hexaniacinate) Effects, Benefits, Dose

Pricing Information:  Inositol | No-Flush Niacin (inositol hexanicotinate)

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