L-Glutamine Conclusion / References
by Ivy Greenwell -- reprinted by permission from Bill Faloon of
The Life Extension Foundation
Glutamine, the most abundant
amino acid in humans, is vital to the proper functioning of our bodies.
While the role of glutamine in these
and other situations is promising, additional research is needed.
The role of glutamine in the body
and the potential advantages of glutamine
supplementation for individuals is the focus of on-going intense
research efforts throughout the world.
There is also a suspicion that toxic residues from
the compounds formerly used for bleaching white flour may have contributed to the increase
in neurodegenerative diseases -- again by inhibiting glutamine synthase. A big challenge in
neuro-protection is avoiding neurotoxins that might impair
the quick conversion of glutamate to glutamine thus, enhancing the production of
(of vitamins/minerals, etc. -- not
fasting) can likewise lead to glial
and thus to the inability of glia to remove excitatory neurotransmitters (glutamate and
aspartate) from the synaptic junctions. In summary, glutamate excitotoxicity arises only
under certain pathological conditions such as stroke, extremely high fever, certain viral
infections, the presence of neurotoxins, or severe inflammation.
It can be due
to excess release of glutamate by the neurons (stroke)
and/or to glial malfunction where the glia
are incapable of secreting enough glutamine synthase in order to convert glutamate to
glutamine. Glutamine as such cannot harm the brain. On the contrary, it is very beneficial
to the brain. Any excess glutamine simply leaves the brain, being donated to the body.
There are many reasons for taking
l-glutamine: Healthier intestines, stronger immune system, enhanced
muscle tone, helps combat fatigue and blood sugar issues and encourages a more agile brain. For therapeutic uses, glutamine is especially recommended for
people who suffer from problems such as Irritable Bowel Syndrome, colitis, Chron's Disease, frequent NSAID users who need to protect their
gastrointestinal tract, and anyone under heavy stress
(including strenuous exercise) or recovering from injury or other trauma.
It may also be
helpful as an adjunct therapy for decreasing alcohol use and/or cocaine and
its derivatives. It supports growth
release (when taken on an empty stomach before exercise or bedtime). It is also used by athletes to improve exercise
endurance since it can actually turn itself into a carbohydrate when carbohydrate depleted.
and d,l phenylalanine in association
with L-Glutamine is an additional consideration concerning lessening the desire
for alcohol and carbohydrates.
Glutamine has a long history of curbing the desire for alcohol and
Take 5-20 grams of L-Glutamine per day when needed, between 2 and 3 grams at the
onset of a desire for sweets and/or alcohol, and up to 40 grams per day for more
Even though glutamine is nontoxic, it
is recommended that you consult a health practitioner before using high doses.
canc patients, patients with advanced liver disease, and those with neurological
diseases including stroke and epilepsy should use glutamine only with the permission of
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