Epidemiological studies show that increased intake of polyphenols is associated with a reduced risk of major cardiac events. The ability of cocoa polyphenols to support endothelial function by maintaining healthy nitric oxide levels is the primary protective mechanism. The secondary benefit of suppressing dangerous inflammatory factors is another manner by which cocoa polyphenols may reduce cardiovascular risks.4-8 The Life Extension Mix formula has been upgraded to provide 30 mg of standardized cocoa polyphenols in each daily dose. Based on the research this is the minimum potency of cocoa polyphenols that healthy people will benefit from consuming each day.
Life Extension Mix also contains high potency green tea. Life Extension Mix provides 325 mg of a decaffeinated green tea extract that is standardized to contain 98% (318.5 mg) of polyphenols and 45% (146.25 mg) of epigallocatechin gallate EGCG) to which scientists attribute green tea's health benefits.9-15 The amount of polyphenols (including EGCG) in Life Extension Mix is equivalent to drinking 3-6 cups of green tea per day. Scientists have identified multiple mechanisms by which green tea extract protects against LDL oxidation, neuronal oxidation, and a host of other structural and functional age related changes.
Fruit and Vegetable Extracts - Luteolin is a flavonoid found in parsley, artichoke, basil, celery and other foods. When measured against 27 other flavonoids, luteolin provided the best DNA protection. One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. Another unique benefit is luteolin's ability to suppress excess levels of dangerous inflammatory cytokines such as interleukin-6 and interleukin 1B.16 Life Extension Mix contains a standardized dose of 8 mg luteolin.
Broccoli is touted as one of the most important vegetables to help maintain healthy DNA. Broccoli contains several active constituents with sulphoraphane being the most significant because of its unique detoxification and DNA protecting effects. Life Extension Mix provides a concentrated broccoli mixture that provides standardized extracts of sulphoraphane and glucosinolates, two compounds attributed to broccoli's multiple protective benefits. Broccoli is also a natural source of gene protecting chlorophyll.17-21
D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli and Brussels sprouts. D-glucarate effectively supports a detoxification process that helps to remove DNA toxins from the body.22,23 The daily dose of Life Extension Mix provides 200 mg D-glucarate.
Lutein, an extract found in spinach and collard greens, has been shown to help maintain critical pigments in the eye macula, while the carotenoid alpha-carotene has demonstrated antioxidant activity far greater than beta-carotene. Lycopene is the red carotenoid in tomatoes has shown potent effects in helping to maintain healthy DNA structure. Lycopene also protects against LDL oxidation, and aids in maintaining a healthy prostate. Life Extension Mix contains 60 times more lutein and 10 times more lycopene compared to Centrum. Most multivitamin supplements provide no vegetable extracts.
The media has publicized the multiple benefits of fruits such as blackberry, cranberry, elderberry, cherry, plums and persimmon. Life Extension Mix has a customized blend of these and other fruits that studies indicate provide multiple favorable effects in the body. Wild blueberry extract, concentrated and standardized, has been added to provide optimal beneficial effects. Pomegranate extract standardized to provide the punicalagins and other polyphenols found in up to 2.6 ounces of pomegranate juice.
Olive oil consumption is one of the important factors behind the health benefits of the "Mediterranean Diet."24,25 Researchers have discovered that there are up to 300 times more polyphenol compounds in olive water compared to olive oil.26,27 Olive polyphenols have been the subject of numerous studies pointing toward their benefits in many different areas. Olive polyphenols help to protect against LDL oxidation, suppress free radicals, and stabilize cell membranes.28-30 Life Extension Mix contains a potent olive juice extract standardized to contain 7 percent of the best-documented polyphenol called hydroxytyrosol.31 The amount of hydroxytyrosol in Life Extension Mix is equivalent to drinking one ounce of virgin olive oil per day.32-33
Sesame lignans enhance the effects of vitamin E. Sesame and its lignans have a broad range of applications in human health. This includes increasing human tissue levels of vitamin E by facilitating carrier proteins in the liver to deliver nutrients to cells throughout the body.34,35
Sesame lignans increase the anti-inflammatory index of fish oils and help maintain healthy cholesterol/LDL levels in those already within normal range.36-39 Life Extension Mix contains 10 mg sesame lignan extract to provide the direct benefits of the lignans and augment the effects of vitamin E and other nutrients in the body such as gamma-tocopherol and gamma-linolenic acid (GLA).
Pterostilbene is a compound naturally found in blueberries and grapes that has been shown to have beneficial, antiaging effects on gene expression and to promote healthy cognitive function.
High potency vitamin D3: Doctors used to be concerned that too much vitamin D could be toxic. Over the past few years, however, an increasing body of evidence indicates that it takes much higher doses of vitamin D (perhaps over 10,000 IU/day) to result in toxicity in a healthy person. The concern expressed by researchers today is that fear of vitamin D toxicity is keeping many people from supplementing with enough vitamin D which is critical for maintaining bone density. In response to studies showing that even those who take standard vitamin D supplements are not obtaining adequate amounts, Life Extension Mix provides 800 IU vitamin D3 per daily dose. In addition, consider the fact that approximately 20 minutes of midday sun exposure (at least 40% of skin exposed) equates to absorbing approximately 20,000 IU into the typical Caucasian body. Those with darker skin require significantly more exposure to get the same effect.
Life Extension Mix contains only the dry powder form of vitamin E. This natural form of vitamin E (succinate) has been shown to promote healthy DNA better than other forms.
Minerals - Some scientific evidence suggests that consumption of selenium may reduce the risk of certain forms of cancer. Life Extension Mix contains a superior form of selenium as 50% se-methylselenocysteine, 25% L-selenomethionine (yeast free) (SelenoPure4), and 25% sodium selenate.
Zinc is often poorly absorbed so as a result, The Life Extension Foundation includes two of the most bioavailable forms of zinc in Life Extension Mix.
Boron is not only needed to maintain healthy bone density but may also help promote healthy prostate cell development.
Life Extension Mix contains a superior and biologically active trivalent chromium complex. It is a unique food form of a bio-organic water soluble matrix. Chromium, along with magnesium and biotin, are nutrients required to maintain healthy blood sugar levels in those already within normal range.40,41
A higher potency magnesium, included in Life Extension Mix, is needed for more than 300 biochemical reactions in the body. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, supports a healthy immune system, and keeps bones strong. Magnesium also helps maintain healthy blood sugar and blood pressure levels in those already within normal range, and is known to be involved in energy metabolism and protein synthesis.
Cholinergic Nutrients: Maintaining high levels of acetylcholine in the brain by consuming choline helps correct mild memory problems associated with aging and helps protect against age-associated mental decline.
Life Extension Mix saves time and money by combining the most popular nutrient supplements in one product, eliminating the need to take separate bottles of B-complex, vitamins C and E, mineral supplements and much more that would be required to achieve the same effects. Life Extension Mix supplies the most powerful antioxidants, including water and fat soluble vitamin C, the ideal form of alpha vitamin E, and plant extracts that help protect against cellular DNA damage. Other ingredients in Life Extension Mix enhance beneficial DNA methylation patterns, and help maintain glycemic control and healthy levels of LDL in those already within normal range. Life Extension uses standardized herbal extracts to ensure that our products contain the highest level of biological activity.
Extra Niacin: The formulas with extra niacin contain 862 mg opposed to 190 mg as shown below.
Who Should Not Take Copper: Some people appear to be especially sensitive to copper supplementation. Those with Wilsons disease should avoid copper supplements altogether. Wilsons disease is a genetic disorder that causes copper to accumulate in the liver and then be abnormally delivered in large pools to different parts of the body where it may inflict damage. Also, cancer patients who are on a physician-supervised copper depletion therapy should avoid copper supplementation. As such, we offer versions of Life Extension Mix without any copper for those who are already obtaining enough copper from other sources or those who should avoid supplements containing copper.
The ingredients below pertain to all formulas except the ones without copper. The without copper formulas contain everything you see below except copper.
Other Ingredients: Other ingredients: Dicalcium phosphate, stearic acid, microcrystalline cellulose, maltodextrin, vegetable stearate, croscarmellose sodium, silica, pharmaceutical glaze. Contains soybeans. Contains corn and sesame.
Betatene is a registered trademark of Cognis Nutrition and Health.
It is rare but some people may experience a "die-off" effect, also called the Herxheimer Reaction. A die-off effect is caused by a rapid increase in volume of stored waste material (mercury, fomaldehyde, aluminum, cosmetics, etc.) and pathogens in the body. They can end up in the lymph system due to the binding/cleansing action of several of the nutrients included in Life Extension Mix. Reactions to the die-off effect can include fatigue, diarrhea, headaches, muscle/joint achiness, and flu-like symptoms. These reactions are temporary and will pass once your body has expelled the circulating toxins. If these detoxifying symptoms are too uncomfortable, reduce the amount of Life Extension Mix you consume temporarily. Once your body is free of poisons, you will have achieved an important step in optimizing your health. This is one of the reasons we suggest you build-up to full menu (if you are starting out or have been off for awhile).
Dosage and Use: Dedicated Life Extensionists consume the full menu which is 9 tablets per day - 3 as the first dose, 3 more 6 hours later, and the last 3 in another 6 hours. Or, if you are taking capsules -- 14 capsules taken in divided doses. Or, if your are taking the powder, 3 scoops of the powder in divided doses. Read how to build-up to the full menu here.
The niacin in this product may cause flushing (a feeling of warmth and reddening of the skin). This effect is temporary and harmless. Refrigeration of product (or a cool dark storage place) is recommended.
Caution: This product should not be used by individuals who have an allergy to sesame.
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