The scientific literature is replete with information supporting the possibility of an association with lithium orotate and Alzheimer's Disease. Many Research Scientists have reported in various scientific journals and other health publications about the positive effects that lithium may have on this debilitating condition.
Dr. Ward Dean states in one of his article series, Crosslinkage Theory of Aging: Part III -- The Neurotoxic Effects of Aluminum, "The neurotoxic effects of aluminum have been known for many years. More recently, scientists have shown that aluminum accumulation may contribute to Parkinsons disease, Downs syndrome, and Alzheimers disease. And, he continues, "it is intriguing to consider that perhaps long-term treatment with low doses of lithium may be an effective way to displace protein bound aluminum in animals and humans."
Chris D. Meletis, N.D. reports in Vitamin Research News, "Studies show that lithium, in general, inhibits the atrophy of the hippocampus. Atrophy of the human hippocampus is seen in a variety of disorders including Alzheimers disease."(1)
Jonathan V. Wright, M.D. states in his one
of his newsletters,
"Medical experts at one time
believed that once our brains matured, it was all downhill from then
on. Decades of autopsies, x-rays, and, more recently, brain scans have
repeatedly shown that brains shrink measurably with aging. But,
according to their report in the Lancet, Wayne State University
(Detroit) researchers found that lithium has the ability to both
protect and renew brain cells.(2) Eight of 10 individuals who took
lithium showed an average 3 percent increase in brain grey matter in
just four weeks."
Linda Fugate, Ph.D. states in Vitamin Research News, "Professor Bjorksten demonstrated that lithium was an effective aluminum chelator and cross-linkage inhibitor. Bjorksten stated that lithium continues to be the most effective electrolyte for aluminum detachment."(4)
Jonathan V. Wright, M.D.
mentions in one of
his newsletters, "Researchers have reported that lithium inhibits beta-amyloid
secretion, and also prevents damage caused by beta-amyloid protein
once it's been formed.(5-8) Beta-amyloid peptide is a signature
protein involved in Alzheimer's Disease: the more beta-amyloid
protein, the worse the Alzheimer's. Over-activation of a brain cell protein called tau protein also
contributes to neuronal degeneration in Alzheimer's Disease, as does
the formation of neurofibrillary tangles. Lithium inhibits both of
these nerve-cell damaging problems."(9,10)
Dr. Ward Dean adds in Crosslinkage Theory of Aging: Part III -- The Neurotoxic Effects of Aluminum, "Clearly, it is important to reduce our exposure to aluminum. The most obvious steps are to drink only filtered water, and to avoid aluminum cookware, aluminum foil-wrapped food, beverages in aluminum cans, aluminum-containing anti-acids, aluminum-containing antiperspirants, and foods made with aluminum, like baking powder (not the same as baking soda) and most non-dairy coffee creamers."
Jonathan V. Wright, M.D. comments, "So it appears that lithium can protect against normal brain erosion and shrinkage that would otherwise occur over the course of our lives. But lithium also protects the brain from other less "normal" problems too, like damage caused by prescription medications and strokes."
And, Dr. Wright states, "I've been taking a lithium supplement every day for several years." He continues, "The amounts of lithium I recommend for brain anti-aging range from 10 to 20 milligrams (from lithium aspartate or lithium orotate) daily. I've actually been recommending these amounts since the 1970s." If you're interested in keeping your brain as young as possible for as long as possible, you should definitely consider lithium."
Several references in the scientific literature have been made concerning the relationship of lithium and fibromyalgia.
Dr. Norm Shealy (a holistic pain and depression specialist) recommends 20-45mg (elemental) per day in divided doses throughout the day ... such as 5 caps in the AM and 5 caps in the PM. Over the years, Dr. Shealy’s intensive pain and stress management research has resulted in numerous pioneering treatments. His published works total over 325. His seminars and workshops are given worldwide, and attended by physicians and lay persons alike. He has acted as consultant to leaders in every specialty, including the personal physicians of President’s Kennedy and Eisenhower. In 1978, Norm was instrumental in developing the American Holistic Medical Association.
Dr. Toinette Fontrier of the Department of Anesthesiology, Wake Forest University Medical Center states, "Dr. Lewis and I believe that fibromyalgia may be related to a calcium-parathyroid axis dysfunction. Lithium causes a brief rise in parathyroid hormone. Perhaps this is the reason for the drugs efficacy." She continues, "Lithium has a long history of safe use. It is inexpensive and readily available. Side effects are usually well tolerated. If large doses are needed, blood levels should be monitored. It is worth a try." (11,12,13)
Dr. Jonathan Wright adds, "One study examined three women suffering from fibromyalgia, none of whom had responded to conventional treatment. When researchers added lithium to the women's current treatment, all three noticed a marked reduction in their symptoms.(14) The authors of the study didn't explain why they didn't have the women discontinue their ineffective conventional treatments, but I've got a pretty good idea that their motives might have had something to do with the fact that the conventional treatments, as useless as they were for these women, are the "standard protocol."
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