Lithium Orotate - References

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Lithium Orotate References

1. Dhikav V, Anand KS. Is hippocampal atrophy a future drug target? Med Hypotheses. 2006 Nov 10; [Epub ahead of print].
2. Moore GJ, et al. Lithium-induced increase in human brain grey matter. Lancet 2000; 356: 1,241-1,242
3. Chuang D, Hashimoto R, Kanai H, Leeds P, Senatorov V. Lithium stimulates progenitor proliferation in cultured brain neurons. Neuroscience 2003; 117(1): 55-61

4. Bjorksten, Johan. Pathways to the decisive extension of the human specific lifespan, J American Geriatrics Soc, 1977 a, 25: 396-399.
5. Takashima A, Murayama M, Murayama O, Park J, Sato S, Sun X, Yamaguchi H. Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neuroscience Letters 2002; 321(1-2): 61-64.
6. Chuang D, Chen R, Leeds P, Qian Y, Wei H, Wei W. beta-Amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. European Journal of Pharmacology 2000; 392(3): 117-123.
7. Diaz-Nido J, Alvarez G, Avila J, Bogonez E, Munoz-Montano JR, Satrustegui J. Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration. FEBS Letters 1999; 453(3): 260-264.
8. Ibid.

9. Munoz-Montano JR, Moreno FJ, Avila J, Diaz-Nido J. Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons FEBS Letters 1997; 411(2-3): 183-188.
10. Radesater A, Peterson E, Nilsson Y, Luthman J, Leonov S, Budd SL, Bhat RV, Backstrom A. Inhibition of GSK3beta by lithium attenuates tau phosphorylation and degeneration. Society for Neuroscience Abstracts 2001; 27(1): 1,437.
11. Tyber MA. Lithium carbonate augmentation therapy in fibromyalgia. Can Med Assoc J 1990; 143: 9024.
12. Teasell RW. Lithium therapy for fibromyalgia [letter]. Can Med Assoc J 1991; 144: 1223.
13. Lewis JM, Fontrier T. Lithium and fibromyalgia. J Musculoskeletal Pain 2003; 11: 6970.
14. Tyber MA. Can Med Assoc J 1990; 143: 902-904
15. Sartori HE. Lithium orotate in the treatment of alcoholism and related conditions. Alcohol. 1986 Mar-Apr;3(2):97-100.
16. Nieper HA. The clinical application of lithium orotate. Agressologie. 1973;14(6):407-411.
17. M. Anke, W. Arnhold, B. Groppel, and U. Krause, The Biological Importance of Lithium, In: Lithium in Biology and Medicine, ed. G. N. Schrauzer and K. F. Klippel, VCH Verlagsgesellschaft, Weinheim, New York, pp. 147-167, 1991.
18. H. Klemfuss and G. N. Schrauzer, Effects of Nutritional Lithium Deficiency on Behavior in Rats, Biol. Trace Element Res. 48, 131-139, 1995.
19. A. I. Fleishman, P. H. Lenz, and M. L. Bierenbaum, Effect of Lithium upon Lipid Metabolism in Rats, Journal of Nutrition, 104, 1242-1254, 1974.
20. E. B. Dawson, The Relationship of Tap Water and Physiological Levels of Lithium to Mental Hospital Admission and Homicide in Texas. In: Lithium in Biology and Medicine, ed. G. N. Schrauzer and K. F. Klippel, VCH Verlagsgesellschaft, Weinheim, New York, pp. 147-167, 1991.
21. G. N. Schrauzer and K. P. Shrestha, Lithium in Drinking Water and the Incidences of Crimes, Suicides, and Arrests Related to Drug Addictions, Biol. Trace Element Res. 25, pp. 105-113, 1990.
22. G. N. Schrauzer, K. P. Shrestha, and M. F. Flores-Arce, Lithium in Scalp Hair of Adults, Students, and Violent Criminals, Biol. Trace Element Res. 34, 161-176, 1992.
23. McMillan TM. Lithium and the treatment of alcoholism: a critical review. British Journal of Addiction 1981; 76: 245-258.
24. Randall S et al. Effect of lithium on viral replication. In Birch NJ (editor) Lithium and the Cell: Pharmacology and Biochemistry, Academic Press, New York, 1991, pp. 99-112.
25. Amsterdam JD, Maislin G, Hooper MB. Suppression of herpes simplex virus infections with oral lithium carbonate -- a possible antiviral activity. Pharmacotherapy 1996; 16(6): 1,070-1,075.

  • Keep lithium orotate out of reach of children,
  • Do not exceed recommended dose,
  • If you have a bad reaction or side-effects, discontinue use immediately,
  • When using lithium orotate, please inform your physician,
  • Lithium should not be used by individuals with significant renal or cardiovascular diseases, severe debilitation or dehydration, or sodium depletion, and by individuals who are taking diuretics or ACE inhibitors,
  • Consult your doctor before use if you are taking anti-hypertensive drugs, anti-inflammatory drugs, analgesic drugs or insulin,
  • Lithium should not be used by pregnant women and breast-feeding mothers.

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