Luteolin - Unremitting systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to suppress these dangerous inflammatory cytokines.20-26
Benfotiamine blocks multiple destructive biochemical pathways, including AGEs formation pathway, which is induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 7485 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal.27-29 Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.30
Pyridoxal 5-Phosphate - Aging results in the formation of toxic advanced glycation end products throughout the body. Pyridoxal 5-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions.31-33
R-Lipoic Acid - Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. The microencapsulated Bio-Enhanced R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.34-39
Acetyl-L-Carnitine Arginate - The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. ArginoCarn Acetyl-L-carnitine arginate is a patented form of carnitine that has been shown in cell cultures to stimulate the growth of neurites.40-42 Taking all of these ingredients separately would be prohibitively expensive. Life Extension members can benefit from all of them in this one cost-effective, comprehensive formulation to promote mitochondrial structure, function and formation.
Mitochondrial Energy Optimizer with BioPQQ incorporates the tremendous advances in our knowledge about the importance of maintaining mitochondrial integrity as we age. Scientists now know that mitochondria decay in aging is a major driving force behind the aging process.
As the mitochondria burn fatty acids to produce cellular energy, it generates a host of free radicals in the process. That is why a mitochondrial antioxidant like lipoic acid (called R-lipoic acid) is so critical. This comprehensive formula provides a much more potent form of lipoic acid than its predecessor, ChronoForte, along with a more effective form of carnitine, called acetyl-l-carnitine-arginate.
Fatty acids that serve as the fuel for the mitochondria are pulled across the mitochondrial membrane by carnitine and other forms, like acetyl-l-carnitine. As we age, we lose the ability to pull fatty acids across the membrane because of damage that occurs inside the mitochondria. From birth we have a 1-2% leakage of reactive oxygen species from the respiratory chain in the mitochondria. That, in turn, increases dramatically with age while generating huge amounts of free radicals. We call this leakage the loss of respiratory control.
Mitochondrial Energy Optimizer formula helps restore mitochondrial respiratory control by lowering natural antioxidant leakage and boosting cellular levels of R-lipoic acid, acetyl-l-carnitine, and endogenous antioxidant enzymes.Glycation and Aging
As humans age, their proteins become irreversibly damaged by lethal glycation reactions. Glycation is the cross-linking of proteins and sugar to form nonfunctioning structures in the body, which can lead to alterations of normal cell function. Carnosine is not only the premier anti-glycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.1-5
The new Mitochondrial Energy Optimizer with BioPQQ is designed to counteract age-related structural and functional changes by providing the following unique ingredients:
Systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to suppress these dangerous inflammatory cytokines.6-11Glucose and Free Radicals
Benfotiamine blocks multiple destructive biochemical pathways, including advanced glycation end-products (AGEs) which are induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 7485 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal.12-14 Benfotiamine can correct endothelial cell defects induced by high glucose. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.15
Aging results in protein glycation and the formation of AGEs in tissues throughout our body. Pyridoxamine, a form of vitamin B6, is an efficient AGE inhibitor or cross-link breaker that has been validated to protect the bodys aging proteins against carbonyl stress via multiple independent mechanisms.16-17
Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. A new micro-encapsulated Bio-Enhanced R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market but R-lipoic acid is far more potent.18-21 The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. Acetyl-L-carnitine arginate is a patented form of carnitine that also stimulates the growth of neurites in the brain.
Other Ingredients: Other ingredients: gelatin, vegetable stearate, silica. Contains soybeans.
Dosage and Use: Take two capsules, twice a day, or as directed by a healthcare practitioner. This product can be taken with or without food.
Note: It is important to take four capsules per day of the Mitochondrial Energy Optimizer with BioPQQ in order to benefit from carnosine. The reason for this is that the body automatically metabolizes lower amounts of carnosine into an inert substance, but the body cannot neutralize the amount of carnosine (1000 mg) contained in four capsules of Mitochondrial Energy Optimizer with BioPQQ in any given 24 hour period.
Energy Optimizer w/BioPQQ |
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