Quercetin (Quercitin) Supports Problems Associated with Obesity, Cancer, and Heart Disease
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By Julius Goepp, MD
Quercetin’s ability to suppress cell proliferation and to minimize DNA damage has made it of natural interest as a cancer-preventive nutrient
free from negative side effects.36,37 Epidemiologic studies strongly suggest that quercetin and other flavonoid intake
is correlated with a reduced risk of certain cancers.38-43 Researchers have demonstrated quercetin’s ability to prevent or slow tumor development in experiments involving cancers of the brain, liver, colon, and other tissues.
Clinical evidence of quercetin’s positive side
effects in cancer prevention and therapy is rapidly accumulating. An early Phase
1 clinical trial of quercetin in patients with various cancer types demonstrated a decrease in activity of enzymes required for tumor growth in 9 of 11 patients
studied.48 Two patients with advanced cancers that failed to respond to standard chemotherapy experienced significant drops in chemical tumor markers during the study.
More recently, Cleveland Clinic oncologists investigated quercetin in patients who had familial adenomatous polyposis, an inherited condition producing hundreds of colonic
polyps that ultimately turn to cancer.49
They combined the quercetin with
curcumin, another nutrient with known anti-inflammatory and tumor-blocking potential. Both nutrients were taken by five patients and they were followed for six months. All patients had a reduction in both size (60%) and number of polyps (51%) over the course of treatment with minimal adverse
side effects and no evidence of
laboratory abnormalities. The researchers strongly encouraged larger controlled trials to further explore the supplements’ potential cancer-fighting abilities.
The diverse and multiple effects of quercetin on specific disease processes are overwhelming and are certain to have an effect simply by reducing the impact of chronic illness. But, there seems to be something else going on with this surprising polyphenol ... something
independent of its anti-disease activity. There is evidence that quercetin has a direct
positive side effect on prolonging life span, at least in simple laboratory organisms. For example, a Portuguese biochemistry research group has shown that, by increasing resistance to oxidative
stress, quercetin supplements prolong the life span of laboratory yeast cells in culture by 60%.4
Biologists at Humboldt University in Berlin took these findings several steps further in their work on a simple roundworm, C. elegans. They demonstrated that feeding the tiny worms flavonoid-rich diets improved overall health and longevity.50
deeper, the same group traced these powerful positive side effects to the quercetin content of the supplement. They’ve even identified a set of four specific genes that seem to be activated by quercetin, pinpointing the precision with which this nutrient acts.50,51 Other scientists have
found evidence that quercetin may mimic many beneficial biological effects of caloric restriction, which extends life span in animals and humans.5,52,53 The immediate impact on humans has also been shown by neuroscientists in Kentucky.
They discovered that brain cells could be protected from the
devastating negative side effects of the toxic protein found in Alzheimer’s disease, beta-amyloid. They pre-treated the cells with quercetin and this apparently reduced free radical damage caused by the deadly protein.54
Dosage and Safety
Health care practitioners recommend quercetin in doses ranging from 50 mg to 500 mg, one to three times daily.2,55 Quercetin is considered safe and well tolerated. Pregnant or nursing women should speak with a physician before using quercetin.2
Quercetin, a ubiquitous polyphenol found especially in apples, onions, and red grapes has been ignored for years while other members of its class took the limelight. In just the past two years, however, a virtual explosion of information has emerged about this versatile molecule. We now understand that it can affect disease processes as different as obesity, cardiovascular disease, cancer, and asthma, through its powerful antioxidant
positive side effects
along with reducing inflammation throughout the body. Even more astonishing, it is now clear that quercetin may have a direct and independent effect on prolonging life itself
through mechanisms that are becoming less mysterious as scientists focus their attention deep inside cellular processes.
- For dietary supplement use only,
- Keep Quercetin (Quercitin) Bioflavonoids
supplements out of reach of children,
- Do not exceed recommended dosage,
- If you have a bad reaction or negative side effects, discontinue use immediately,
- When using, please inform your
- If you are pregnant, lactating
or have a medical condition, consult your health care
professional before using this or any other nutritional supplement,
- If side effects of allergic
reaction occurs from taking Quercetin (Quercitin) Bioflavonoids, discontinue immediately.
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