Resveratrol/Red Wine Structure - Wall Street Journal Article

Welcome To
SmartBodyz Nutrition
Your Online Source for Nutritional Supplements and Related Research

Resveratrol/Red Wine Structure - Wall Street Journal Article
Home Products
A-K
Products
L-Z
News / Studies Customer Service MX GuardDog Spam Blocker View Cart
Live Search
Buy anything from eBay!

Resveratrol / Red Wine Structure - Wall Street Journal Article

Research has revealed that resveratrol has anti-aging effects in some animals, extending the lifespan of yeast by 60%, worms and flies by 30%, and fish by about 60%.

Since the 1930s its been known that calorie restriction by about a third can slow the biological forces of aging.  Scientists began to claim that it's possible to mimic the anti-aging effect with a molecule from red wine called resveratrol, reports David Stipp in The Wall Street Journal (10/30/06).  See below link.

Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement.

Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals.


The Wall Street Journal
October 30, 2006; Page A1

Youthful Pursuit
Researchers Seek Key to Antiaging In Calorie Cutback

A Controversial Hypothesis Draws Scientists, Investors;  Will It Work in Humans?  Fighting Fat in Lab Mice
by DAVID STIPP

 Resveratrol in Red Wine


MSNBC -- 12-06-2010

Chemicals in Apple Skins, Wine Could Help Fight Alzheimer's by Emily Sohn

A compound found in red wine may extend the human life span and help with Alzheimer's Disease.  A report from the front lines -- http://www.msnbc.msn.com/id/40417511


Health News
by Vitamins Research Staff

Very low calorie diets are all the rage these days -- but not for the reasons you might think.  Aside from keeping you slender, research shows that if you eat 10 to 30 percent less than the average person, you can also tack years onto your life -- that is, if you can keep up with this type of diet.  For most, constant hunger pangs make drastic calorie cutbacks far too tough to maintain over the long haul.

But what if you could get all of the health benefits of caloric restriction without the grueling dietary demands?  It may sound impossible, but recent research on a unique natural compound suggests that you can have your cake and, eat it too.

Resveratrol, a phytonutrient commonly found in red grapes and wine, has attracted widespread attention for its astounding ability to put the brakes on aging.  Its effects on longevity in mammals was first investigated back in 2006, when scientists discovered that resveratrol supplementation can inhibit complications of obesity -- including enlarged liver, muscle inflammation, and early signs of heart disease and diabetes in overfed mice.1

Soon after, another study added more steam to the theory ... this time showing that large amounts of resveratrol could double physical endurance (including oxygen consumption efficiency and grip strength) in healthy young mice.  As a result, excess calories were more readily burned off and weight gain prevented.2

Scientists still arent sure how to account for these incredible benefits but they think its because resveratrol is able to mimic the effects of caloric restriction (CR) by switching on the "longevity gene" called SIRT1.  Mice with higher levels of SIRT1 (due to genetic alterations or resveratrol consumption) show greater energy expenditure, reduced weight gain, and increased insulin sensitivity -- all in spite of a high-fat, high-calorie diet.3-4  And those arent the only benefits that resveratrol and caloric restriction have in common.

In a study performed in 2007, researchers found that while mice with high-calorie diets lived longer while taking resveratrol, mice in the standard diet group also benefited from resveratrol supplementation showing improved heart function, bone density, motor function, and delayed the onset of cataracts.5  Its effects on heart health are particularly pronounced.  More recent studies reveal that resveratrol mimics the effects of caloric restriction and can inhibit cardiac aging by 90 percent.6

While starvation-free longevity might seem too good to be true, rest assured that its not.

References for "Health News" article:
1. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-342.

2. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-1122.

3. Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschp MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci USA. 2008;105(28):9793-9798.

4. Sun C, Zhang F, Ge X, et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 2007;6:307-319.

5. Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008 Aug;8(2):157-168.

6. Barger JL, Kayo T, Vann JM, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE. 2008 Jun 4;3(6):e2264.


In the August, 2009 issue of The Journal of the Federation of American Societies for Experimental Biology (FASEB Journal), researchers from the University of Singapore and the University of Glasgow in Scotland report their discovery of the mechanism supporting the ability of resveratrol, an antioxidant compound that occurs in red wine, to control acute inflammation.

"Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment," stated study coauthor Alirio Melendez, who is a senior lecturer on the faculty of medicine at Glasgow Biomedical Research Centre. "Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs. The ultimate goal of our study was to identify a potential novel therapy to help in the treatment of strong acute inflammatory diseases."

The scientists tested the effect of pretreatment with several concentrations of resveratrol in cultured white blood cells known as neutrophils derived from mice and humans to which a proinflammatory agent was administered. "Pretreatment of human and mouse neutrophils with resveratrol significantly blocked oxidative burst, leukocyte [white blood cell] migration, degranulation, and inflammatory cytokine production," the authors report. "The anti-inflammatory action of resveratrol was a function of inhibition of sphingosine kinase activity within 5 minutes of exposure, its membrane location, and sphingosine kinase1-mediated calcium ion release. We also provide evidence that the sphingosine kinase inhibitory effect of resveratrol was mediated via its ability to block phospholipase D activity."

In another experiment using mice in which peritonitis was induced with the same proinflammatory agent, pretreatment by injection with resveratrol prevented the strong inflammatory response that was observed in the non-pretreated group. Increases in vascular permeability and neutrophil migration and recruitment were blocked, and levels of proinflammatory cytokines including interleukin-6, interleukin-1B, and tumor necrosis factor-alpha were significantly reduced.

The authors suggest an upstream role for sphingosine kinase in the nuclear factor kappa-beta pathway of inflammation. "In light of its pharmacological safety and promising anti-inflammatory activity, resveratrol presents as an attractive compound for phase-1 clinical trials for the assessment of pharmacovigilance, pharmacokinetics and pharmacodynamics in patients with inflammatory conditions," they conclude.

"The therapeutic potential of red wine has been bottled up for thousands of years," FASEB Journal Editor-in-Chief Gerald Weissmann, MD observed, "and now that scientists have uncorked its secrets, they find that studies of how resveratrol works can lead to new treatments for life-threatening inflammation."

Resveratrol 20mg Dose/Info | 100 mg Dose/Info | References

 Order:   Resveratrol Extract | Grape Seed-Skin Extract

Pay it Forward - Give You and Your Loved Ones the Gift of Health!
Sale - In addition to your 25% off, you get another 10% automatic volume discount at checkout on orders of $25 or more ... all items apply (including special sale items).  SECURE SHOPPING CART CREDIT CARD PURCHASES ONLY.  Call-ins do not receive this special discount.
All major credit cards accepted! or, PayPal.
Or , or send a check, money order, or cashiers check with completed order form.

 

Enjoy the benefits of our flat rate shipping and handling!  You receive the same great service for the same shipping price whether you order one item or one hundred!

$5.97 - Within USA only - US Post Office  5-9 business days.

$29.77 - To Canada only (see warning information here) 5-9 business days to customs check point (the only way we ship - US Post Office).

$39.77 - Outside USA only
(see warning here) 7-10 business days to your country's customs check point (the only way we ship - US Post Office).

Save 8.25% on all purchases - Texans and everyone!

It's all tax free!  You will be able to review all charges before they are charged to you.

At checkout (after you click the Add button on any of the order pages), the billing address you enter must match the address where you receive your credit card (security effects).  The shipping address you enter does not have to match.

All orders placed by Noon Central Standard Time (CST) are shipped the same day.  PO Boxes Okay.

Payment by credit card and PayPal is immediate.  Payment by check adds a few more business days -- as soon as funds clear.

We do not sell the information you give us to anyone.


Protecting Your Personal Information
:
We pledge a safe and worry-free shopping experience using the industry standard for Internet security, 128-bit Secure Sockets Layer (SSL) encryption (see an online payments diagram).  SSL scrambles your personal and credit card information as it travels the Internet during the checkout process.  We utilize the Authorize.Net payment gateway.  Your credit card information is encrypted and sent to an Authorize.Net transaction server.  This server sends the data through the network to the card's bank, using a secure, proprietary connection.  When complete, you will receive an approval or decline response.  At no point is your credit card information stored on our server.

For additional information regarding the privacy of your sensitive cardholder data, please read the Authorize.Net Privacy Policy.

SmartBodyz Nutrition Home Page
1000 West 10th, Suite 218
Fort Worth, Texas 76102
Local Telephone: 817-335-1982
Email: DG[at]SmartBodyz.com - replace [at] with @
(helps prevent spam)
Copyright 1996-2016, SmartBodyz Nutrition -- all rights reserved.

Credit Card Processing

Credit Card Processing

You can shop here with safety and confidence.  We have partnered with Authorize.Net, a leading payment gateway since 1996, to offer safe and secure credit card transactions.  We also offer PayPal Checkout.

Order Anything
Amazon Shopping

The information and statements made throughout this web site have not been endorsed/evaluated by the Food and Drug Administration or any other governmental authority, unless otherwise specifically noted.  We do not offer products or services for the benefits or purpose of diagnosis, prescription for, treatment of, or claims to prevent, mitigate or cure any viral or disease condition or be free from side effects.  Please, seek the advice of a competent medical professional about anything you read on our site.

BlogBlogLinks | Testimonials | Privacy | RSS Feed