Saffron A, Appetite Control/Suppressants, Depression, Side Effects, Compulsive Eating - References

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Curb Compulsive Eating Naturally -- Novel Spice Extract, Saffron A, Targets the Neurochemistry of Appetite - References
As seen on DoctorOz.com Show

References
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13. Alger S, Seagle H, Ravussin E. Food intake and energy expenditure in obese female bingers and non-bingers. Int J Obes Relat Metab Disord. 1995 Jan;19(1):11-6.
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15. Alger S, Seagle H, Ravussin E. Food intake and energy expenditure in obese female bingers and non-bingers. Int J Obes Relat Metab Disord. 1995 Jan;19(1):11-6.
16. Konttinen H, Mannisto S, Sarlio-Lahteenkorva S, Silventoinen K, Haukkala A. Emotional eating, depressive symptoms and self-reported food consumption. A population-based study. Appetite. 2010 Feb 4.
17. van Strien T, van der Zwaluw CS, Engels RC. Emotional eating in adolescents: A gene (SLC6A4/5-HTT) - Depressive feelings interaction analysis. J Psychiatr Res. 2010 Apr 21.
18. Clarke H, Flint J, Attwood AS, Munafo MR. Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis. Psychol Med. 2010 Apr 12:1-12.
19. Furman DJ, Hamilton JP, Joormann J, Gotlib IH. Altered timing of amygdala activation during sad mood elaboration as a function of 5-HTTLPR. Soc Cogn Affect Neurosci. 2010 Apr 1.
20. Brocke B, Armbruster D, Muller J, et al. Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle. Mol Psychiatry. 2006 Dec;11(12):1106-12.
21. Hemels ME, Koren G, Einarson TR. Increased use of antidepressants in Canada: 1981-2000. Ann Pharmacother. 2002 Sep;36(9):1375-9.
22. Zimmerman M, Galione JN, Attiullah N, et al. Underrecognition of clinically significant side effects in depressed outpatients. J Clin Psychiatry. 2010 Apr;71(4):484-90.
23. Lee KU, Lee YM, Nam JM, et al. Antidepressant-induced sexual dysfunction among newer antidepressants in a naturalistic setting. Psychiatry Investig. 2010 Mar;7(1):55-9.
24. Hosseinzadeh H, Noraei NB. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res. 2009 Jun;23(6):768-74.
25. Noury J, Bourges C. Enqute sur limpact du complment alimentaire SATIEREAL chez des femmes ayant une tendance lhyperphagie rflexe non pathologique: Nutraveris; 2006.
26. Gout B, Bourges C. Efficacy and safety of an 8-week oral supplementation with a Crocus sativus stigma extract on weight loss, satiety and snacking reduction: a prospective, randomized, double-blind, placebo-controlled trial in healthy women with moderate overweight. In press. 2010.
27. Wang Y, Han T, Zhu Y, et al. Antidepressant properties of bioactive fractions from the extract of Crocus sativus L. J Nat Med. 2010 Jan;64(1):24-30.
28. Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine. 2006 Nov;13(9-10):607-11.
29. Pitsikas N, Boultadakis A, Georgiadou G, Tarantilis PA, Sakellaridis N. Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. Phytomedicine. 2008 Dec;15(12):1135-9.
30. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res. 2005 Feb;19(2):148-51.
31. Agha-Hosseini M, Kashani L, Aleyaseen A, et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG. 2008 Mar;115(4):515-9.
32. Dye L, Blundell JE. Menstrual cycle and appetite control: implications for weight regulation. Hum Reprod. 1997 Jun;12(6):1142-51.
33. Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med. 2004 Sep 2;4:12.
34. Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N, Jamshidi AH. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol. 2005 Feb 28;97(2):281-4.
35. Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):439-42.
36. Uzun S, Kozumplik O, Jakovljevic M, Sedic B. Side effects of treatment with benzodiazepines. Psychiatr Danub. 2010 Mar;22(1):90-3.
37. Pitsikas N, Sakellaridis N. Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat. Behav Brain Res. 2006 Oct 2;173(1):112-5.
38. Pitsikas N, Zisopoulou S, Tarantilis PA, Kanakis CD, Polissiou MG, Sakellaridis N. Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats memory. Behav Brain Res. 2007 Nov 2;183(2):141-6.
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40. Abe K, Saito H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother Res. 2000 May;14(3):149-52.
41. Zhang Y, Shoyama Y, Sugiura M, Saito H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol Pharm Bull. 1994 Feb;17(2):217-21.
42. Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H. Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells. Life Sci. 2001 Nov 2;69(24):2887-98.
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45. Premkumar K, Abraham SK, Santhiya ST, Ramesh A. Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytother Res. 2003 Jun;17(6):614-7.
46. Ochiai T, Ohno S, Soeda S, Tanaka H, Shoyama Y, Shimeno H. Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci Lett. 2004 May 13;362(1):61-4.

Dosage and Use: Take one capsule twice daily (morning and evening) with food or as recommended by a healthcare practitioner.

Caution and Side Effects:  Do not exceed recommended dose. Consult with your healthcare practitioner before using this product if you are taking anti-coagulant or anti-platelet medications or if you have a bleeding disorder or kidney disease. Avoid use during pregnancy.

Warnings Information:

  • Keep Saffron A, appetite control/suppressants out of reach of children,
  • Do not exceed recommended dose,
  • If you have a bad reaction or unwanted side effects, discontinue use immediately,
  • When using Saffron A, appetite control/suppressants to lose weight, please inform your physician,
  • Results may vary from person to person concerning weight loss.
 

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