St. Johns Wort (Wart) Side Effects, Benefits, Information - Dosage

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St. Johns Wort (Wart) Side Effects, Benefits - 60 Caps/300mg
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St. Johns Wort (Wart) Side Effects, Benefits, Information - Dosage

St. Johns Wort is a perennial flowering plant (Hypericum perforatum) that has been used for thousands of years.  Hippocrates was well aware of its benefits for the psyche.  St Johns Wart has stood the test of time, and remains a popular natural non-prescription herb today.

The way St. Johns Wort works is not completely understood, but it seems to involve serotonin reuptake inhibition and inhibition of monoamine oxidase (MAO), an enzyme that degrades serotonin, norepinephrine, and dopamine.

Many studies show St. Johns Wort (and hypericin, an extract of what may be its active ingredient) is superior to placebo and equal to or better than many other alternatives on the market.

St. Johns Wort is preferred by wide margins in Europe (German physicians prescribe 20 times more St. Johns Wart);  not so in the USA.


Supplement Facts:  60 Capsules / 300 mg each.  Serving Size - 1 Capsule

Amount / Serving
St. Johns Wort (Hypericum perforatum) powder extract (leaf and flower) 0.3% (.9mg) hypericum 300 mg

% DV

*Daily Value not established.  


Other Ingredients: Rice flour, maltodextrin, gelatin.  Contains corn and rice.  This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, or gluten. Contains NO artificial sweeteners, flavors, colors, or preservatives.


St. Johns Wort Does Not Cause Serious Side Effects, Study States


A recent study indicates that St. Johns Wort, a herb commonly used to support mental health, does not cause side effects as seen with amitriptyline.

Researchers randomly divided 12 healthy, adult males into three groups in a double-blind, crossover study.  One group received 25 mg of amitriptyline, another group received 255-285 mg of St. Johns wort extract that had 900 mcg of hypericin and a third group received a placebo three times daily for 14 days.  For the next 14 days, study participants received no treatments in order to clear their systems.  Next, subjects were switched into another treatment group until each subject had received each treatment of amitriptyline, St. Johns Wort, and placebo.

When the patients took amitriptyline, they experienced side effects of increased heart rate.  This increase was not noted when they took St. Johns wart.  Amitriptyline also decreased self-rated activity while St. Johns wort did not ... meaning the patients felt as if they were more sedated and less active when on the drug amitriptyline.

Siepmann M, Krause S, Joraschky P, Muck-Weymann M, Kirch W. The effects of St. Johns Wort extract on heart rate variability and quantitative EEG: a comparison with amitriptyline and placebo in healthy men. Br J Clin Pharmacol. 2002 Sep;54(3):277-82.



Hyla Cass, MD states:
"In my own practice, and in the many e-mails I have received from now-happy users of St. Johns Wort (SJW), I have to conclude that while SJW may not be the magic bullet for everyone, it certainly plays a significant role.  For those taking or considering taking SJW, you have nothing to worry about.  The study in JAMA (Editors note: one media generated negative study) does not negate the many fine studies published in other journals that have shown SJW to be just as good as the more expensive prescription drugs in treating "the blues."


Hyla Cass is a psychiatrist and renowned expert in nutrition and mental health.  She is Associate Clinical Professor of Psychiatry at UCLA Medical School and has written best-selling books on natural treatments including:

All About Herbs (Avery, 1999)
All About St. Johns Wort (Avery,1999)
Kava: Natures Answer to Stress, Anxiety, and Sleep Issues (Prima, 1998)
St. Johns Wort:  Natures Blues Buster (Avery, 1998)


Recommended Dosage for St. Johns Wort
Dr. Bloomfield recommends 300 mg of hypericum extract (containing 0.3% standardized hypericin) three times a day.  The adult dosage may be taken by adolescents virtually side effects free.

Cautions:  St. Johns Wart has been known to increase photosensitivity in animals and may cause this same reaction in some people (although there has never been a reported case in humans).  Nevertheless, we recommend that strong sunlight and other sources of ultraviolet light (like tanning booths) be avoided when taking St. Johns Wort.

Warnings Information:

  • For dietary supplement use only,

  • Keep out of reach of children,

  • Do not exceed recommended dosage,

  • If you have a bad reaction or side effects, discontinue use immediately,

  • When using, please inform your physician,

  • If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement,

  • If allergic reaction or side effects occur, discontinue St. Johns Wart supplements immediately.

Order:  St. Johns Wort (Wart) Supplements

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