Citrate (Element, Supplements, Use, Information) - Page 3
by Ward Dean, MD -- Reprinted by permission from
Pat Whittington of Vitamin Research
||In another study, Dr. Skoryna administered
strontium (in the form of strontium gluconate) for at least three
months. The dosage of strontium was only 274 mg per day -- much lower
than the 600 to 700 mg per day he used in his bone study stated
earlier. However, since strontium gluconate is absorbed more
efficiently than strontium carbonate, less strontium was needed to achieve
the same blood level. In many cases, the results were clear-cut and
dramatic. X-rays taken before and after strontium therapy demonstrated
new mineral deposits in areas of bone that had been eroded by the aberrant
cell division. In one patient, a vertebra that appeared to be on the
verge of collapse showed extensive remineralization. Although much of
this newly deposited mineral was no doubt made up of calcium crystals, the
presence of strontium was clearly evident by its characteristic appearance
on the X-rays. These strontium deposits were still visible on X-rays
taken several months after strontium therapy had been discontinued.
Many of the people reported subjective improvements and gained weight while
receiving strontium (weight gain was a problem with this group of people due
to aberrant cell division).
Strontium and Teeth
Strontium also has been shown to support teeth. In a
10-year study, the United States Navy Dental Service examined the teeth of
about 270,000 naval recruits. Of those, 360 were found to have
stronger than usual teeth.
Curiously, 10 percent of those 360
individuals came from a small area around Rossburg, Ohio, where the water contains unusually high
concentrations of strontium. Epidemiologic studies have shown that strontium
concentrations of 6 to 10 mg/liter in the water supply are associated with a
stronger than normal teeth. Administering these levels of strontium also
showed the same in animal studies.8
Strontium and Joint Pain
Based on the studies showing that strontium supports bones, scientists at the Bone and Cartilage Metabolism Research Unit,
University Hospital, Liege, Belgium, hypothesized that strontium might also
improve cartilage metabolism.9 They performed an in
vitro investigation using cartilage-forming cells (chondrocytes) obtained
from normal adults and people with pain the joints.
cultured for 24 to 72 hours with strontium, and Proteoglycan (PG) content
was determined -- i.e., structural components of cartilage, including
glucosamine and chondroitin
sulfate. These substances -- Proteoglycans,
also known as Glycosaminoglycans -- are known to decline dramatically with
The researchers found that strontium strongly stimulated PG
production. This suggests a cartilage-growth-promoting effect of
strontium, and provides a sound basis for clinical testing of
strontium in people who experience joint pain.
Strontium in doses up to 1.7 grams per day appears to offer a safe,
effective and inexpensive approach
and may be of benefit in people with joint pain and bone-related aberrant
cell division, as well as possibly helping with teeth strength. Doses of
680 mg per day appear to be the optimum dose, although lower doses are effective.
Dr. J.Y. Reginster (2002), one of the principal strontium researchers,
cautions that co-administration of strontium with calcium appears to impair
strontium absorption.11 So, I recommend that strontium be taken on an empty
stomach, and that it especially not be taken with other multi-minerals that
usually include calcium.
Although the more recent studies used strontium ranelate, earlier studies
used other salts of strontium, including strontium carbonate, strontium
lactate, and strontium gluconate. It appears that the active ingredient is
strontium, and whatever salt of strontium used is less important than the
amount of strontium consumed.
Also, although the studies cited above used only strontium, I believe that even better results would be achieved by including
other substances such as a broad-spectrum
mineral replacement that includes
D3/boron (taken separately), vitamin K,
plus Xylitol (natural occurring sweetener found in many fruits like
strawberries, pears and plums), ipriflavone,
progesterone cream (and in
some cases, estrogen), and
DHEA. A comprehensive regimen of synergistic
bone-enhancing substances should provide the optimum regimen for supporting
bones and teeth.
1. McCaslin, F.E., Jr., and Janes, J.M. The effect of strontium lactate. Proc Staff Meetings Mayo Clin, 1959,
2. Marie, P.J., and Hott, M. Short-term effects of fluoride and strontium on
bone formation and resorption in the mouse. Metabolism, 1986, 35:547-551.
3. Marie, P.J., Skoryna, S.C., Pivon, R.J., Chabot, G., Glorieux, F.H.,
Stara, J.F. Histomorphometry of bone changes in stable strontium therapy.
In: Trace substances in environmental health XIX, edited by D.D. Hemphill,
University of Missouri, Columbia, Missouri, 1985, 193-208.
4. Meunier, P.J., Slosman, D.O., Delmas, P.D., Sebert, J.L., Brandi, M.L.,
Albanese, C., Lorenc, R., Pors-Nielsen, S., De Vernejoul, M.C., Roces, A.,
Reginster J.Y. Strontium ranelate: dose-dependent effects in established
postmenopausal women -- a 2-year randomized placebo
controlled trial. J Clin Endocrinol Metab, May 2002; 87(5):2060-6.
5. Meunier, P.J., Roux, C., Seeman, E., Ortolani, S., Badurski, J.E.,
Spector, T.D., Cannata, J., Balogh, A., Lemmel, E.M., Pors-Nielsen, S.,
Rizzoli R., Genant, H.K., Reginster J.Y. The effects of strontium ranelate in postmenopausal women.
N Engl J Med, 2004, Jan 29;350(5):459-68.
6. Ortolani S, Vai S. Strontium ranelate: An increased bone quality efficacy at all stages. Bone. 2006 Jan
30;38(2S1):19-22 [Epub ahead of print].
7. Skoryna, S.C., 1981. Effects of oral supplementation with stable
strontium. Can Med Assoc J, 125: 703-712.
8. Gaby, A.R. Preventing and Reversing, Prima Publishing,
Rocklin, CA, 1994.
9. Henrotin Y., Labasse A., Zheng S.X., Galais P., Tsouderos Y., Crielaard
J.M., Reginster J.Y. Strontium ranelate supports cartilage matrix
formation. J Bone Miner Res, 2001, Feb; 16(2):299-308.
10. Hall, D.A. The Ageing of Connective Tissue, Academic Press, San
11. Reginster, J.Y., Deroisy, R., Dougados, M., Jupsin, I., Colette, J.,
Roux, C. Early postmenopausal bone -- strontium ranelate:
the randomized, two-year, double-masked, dose-ranging, placebo-controlled
PREVOS trial. Osteo Int, 2002, Dec;13(12): 925-31.
Citrate - Page 1 | Page
Glucosamine, Chondroitin Sulfate,
MSM, Sulphate |
pH Acid/Alkaline Article