Turmeric (circumin) Health Side Effects, Benefits, Root, Extract

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Turmeric (circumin) Health Benefits, Side Effects, Root, Extract

Curcuminoids
In technical terms, the active constituents of turmeric also called Curcuma longa are known as curcuminoids.  A yellow pigmented substance isolated from the rhizome (root) of curcuma longa, it contains approximately 3% to 5% active curcuminoids.  It is this group of compounds that are responsible for the biological action of turmeric/circumin.  This active extract can be further subdivided into three distinct components:  Curcumin, demethoxy-curcumin and bisdemethoxy circumin and are virtually side effects free.

While each of these chemicals has independent antioxidant activity, research conducted by the Sabinsa Corporation has demonstrated that the most significant benefits are achieved with the intact, naturally occurring curcuminoid complex.

Although, a complete discussion of the benefits of turmeric extract (with standardized active curcuminoid content) is beyond the scope of this review, there are, nevertheless, several particular actions that deserve special mention.

Antioxidant Value
No review of turmeric would be complete without making specific reference to its most significant benefit, that of an antioxidant.  While you may be aware that numerous studies have confirmed turmeric's ability to quench both superoxide and peroxyl radicals, what you may not know is that turmeric was found to be over 5 times more potent than alpha tocopherol (vitamin E) at quenching a wide range of free radicals without side effects.  Since many researchers attribute much of the aging process to the incessant damage caused by free radicals and the subsequent decline in the body's ability to effectively regenerate damaged cells, turmeric root certainly bears at least thorough consideration for inclusion into your daily supplement routine.

With volumes of research being generated each year on curcuminoids, one thing is certain:  We will uncover more and more compelling reasons why turmeric should be incorporated into our supplements and added to our supplement programs.  With all the potential benefits that can be attributed to curcumin intake, we feel it is imperative that we offer our customers the highest quality curcuminoid root extract available.  Our standardized turmeric extract product contains a minimum of 95% curcuminoids including:  83.2% circumin, 9.2% demethoxycurcumin, and 2.6% bisdemethoxy curcumin.

Colorectal Cancer Relationship
Curcumin, the pigment responsible for the yellow color of the spice turmeric, inhibits the activity and side effects of a hormone associated with the development of colorectal cancer.

A gastrointestinal hormone called neurotensin has been linked to the production of an inflammatory protein that accelerates the growth of a variety of cancer cells.  About a third of all colorectal cancer cells have the receptor for neurotensin, which is generated in response to consumption of fat.

The researchers of the current study, which will be published in the October issue of Clinical Cancer Research, found that this gastrointestinal hormone reduced production of IL-8, an inflammatory protein that plays a role in the growth and spread of a variety of human cancer cells, including colorectal and pancreatic tumor cells.

The researchers discovered that in addition to increasing the rate of growth of colon cancer cells, neurotensin is also implicated in cell migration and metastasis.  However, all these negative side effects of neurotensin were turned off by the turmeric-derived curcumin.

The study, authors noted, that neurotensin's effects are dependent upon biochemical signaling pathways inside the cell.  In the current cell culture study, curcumin reduced those signals and side effects, decreasing IL-8 production.  In addition, the study showed that curcumin stopped the neurotensin-mediated migration of colorectal cancer cells -- an ability that could stop the metastasis of colorectal cancer to other sites in the body.

The researchers suggest that circumin may be useful to support the health of colon cancer patients and that it may be useful in suppressing colon cancer in cells that respond to the gastrointestinal hormone neurotensin.

Reference:
Xiaofu W, et al. Circumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells and its side effects. Clinical Cancer Research. October 2006;12(18).

Turmeric & Alzheimer's | Curcumin & Cancer Support

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