Vitamin B6 (B-6, pyridoxine HCL) by Life Extension - Benefits, Deficiency, Overdose, Side Effects

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Carpal Tunnel Syndrome, Menopause, and PMS Support ... The Significance of Daily Intake
The following reprinted by permission from Dusty R. Green, M.Ed., Research Scientist

Like all nutritional supplements, a certain amount of daily consumption is needed for our bodies to achieve optimum health.  Typically, anything less, leaves our bodies open to physiological disrepair.  Many maladies are associated with nutritional deficiencies and by filling that need can often repair the affliction and side effects associated with it.  The preponderance of scientific evidence shows that most health issues may be related to lack of nutritional support.  For example, Vitamin B6 is found in foods such as eggs, brewers yeast, carrots, chicken, fish, brown rice, whole grains, and cabbage.  Unfortunately, you would have to eat thousands of calories each day of any one of these foods to get the amount of B6 your body needs to address any of the health issues mentioned below.

Carpal Tunnel Syndrome
Vitamin B6
(pyridoxine) may offer valuable support to those with carpal tunnel syndrome according to a randomized, double-blind clinical study presented at the American Academy of Nurse Practitioners.  Sixty subjects were involved of which twenty nine (29) received 200 mg daily of pyridoxine and thirty one (31) subjects (control group) received a placebo.  The pyridoxine group responded positively compared to the control group within three weeks of starting treatment of 200 mgs per day.  Other studies (see below) have shown that benefits may take longer to occur -- two to three months of consuming 200 mgs per day.

In addition, some studies show that B6 may support the break-down of atherosclerotic plaque.  Also, other studies show that B6 is a significant helper with menopause and premenstrual syndrome (PMS) issues -- especially when combined with magnesium and potassium.

Some of the best sources of potassium (but not limited to) are bananas, potatoes, oranges (or real juice), cantaloupe (& other melons), and milk.  The pill form of potassium (typically 99mg/pill) provides an insignificant amount, so it is best to get it from foods such as mentioned above.  In contrast, it is best to take magnesium in pill form (at least 500 mg/day and as high as 900 mg/day) since most food sources do not contain significant amounts.  Calcium is required for magnesium to do its job at a ratio of 2:1 over magnesium.

References:  Below

Name:  Vitamin B6, Pyridoxine by Life Extension
Description:  250 mg, 100 vegetable capsules

Supplement Facts:  Serving Size - 1 Vege Capsule

Amount/Serving  % Daily Value
Vitamin B-6 (pyridoxine) 250 mg  12,500


Other Ingredients:  Vegetable cellulose (capsules), microcrystalline cellulose, vegetable stearate.

Does Not Contain:  Yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt preservatives, artificial color, flavor and fragrance.

Vitamin B6 -- Neurotransmitters, Liver Spots, Childrens' Growth, Menopause

Vitamin B6 is essential for amino acid absorption, metabolism and transport, the formation and growth of red blood cells, and for the utilization of many substances used by the nervous system.  A deficiency of vitamin B6 may be associated with side effects associated with menopause, irritability, weakness and nervousness.

Vitamin B6 (pyridoxine) is an important component of the coenzyme PLP which metabolizes amino acids.  Because of its amino acid transfer ability, the body can produce nonessential amino acids from available amino groups as well as metabolize protein and urea.  It is essential because of its participation in more than 100 enzymatic reactions including protein metabolism, conversion of tryptophan to niacin, and neurotransmitter function, among others.

Vitamin B-6, along with B12 and folic acid, plays a beneficial role in maintaining healthy homocysteine levels (heart related).  It complements vitamin B12 in the communication process between nerve cells and is essential for childrens' growth and development.  In addition, B6 works together with vitamins A, C, and E in dissolving rancid fat deposits virtually side effects free.  Rancid fat deposits can be internal and external.  The external variety, called liver spots, can show up in various areas of our skin.

As a natural anti-inflammatory support supplement, consuming bromelain (comes from pineapple) at 1,500 mgs/day, is recommended in conjunction with B6 at 500 mg in divided doses.

Vitamin B6 Deficiency Associated With Inflammation

In a study described online on May 23, 2012 in the Journal of Nutrition, researchers at Tufts University in Boston report a relationship between low levels of plasma pyridoxal-5'-phosphate (PLP), which indicate reduced levels of vitamin B6, with an increase in markers of inflammation.

"Low vitamin B6 status, based on plasma concentrations of pyridoxal-5-phosphate, has been identified in inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes," writes Lydia Sakakeeny of Tufts Jean Mayer USDA Human Nutrition Research Center and her colleagues.  "Our objective was to examine the association between plasma PLP and multiple markers of inflammation in a community-based cohort."

The current study included 2229 men and women enrolled in the Framingham Offspring study, who were recruited in 1971 and have undergone periodic examinations thereafter.  Blood drawn between 1998 and 2001 was analyzed for plasma PLP and 13 markers of inflammation, including C-reactive protein, fibrinogen, interluekin-6, tumor necrosis factor-alpha and other factors.

The researchers created inflammation scores based on the values of each inflammatory marker. An inverse relationship was observed between high inflammation scores and low levels of PLP.  The authors note that decreased plasma PLP levels may reflect mobilization of PLP into inflammatory sites and that a causative relationship between reduced vitamin B6 levels and inflammation cannot be determined.  However, they conclude that "This study in combination with past findings further supports our hypothesis that inflammation is associated with a functional deficiency of vitamin B6."

Caution:  Some people have reported side effects symptoms of peripheral neuropathy (tingling, numbness sensation, decreased sensation to touch or balance difficulties) when taking vitamin B6 in doses above 500 mg daily -- especially if the nutrient is taken without other B-complex vitamins.  Vitamin B6 may be toxic in doses of 2,000 mgs or more per day.  Researchers (see Schaumberg below) have reported reversible nerve damage in four of seven patients who had been taking these amounts for two to four months.  Five of the seven were women of which two were advised by their gynecologists to take the excessive amounts.  One of the two men was taking these amounts as advised by his psychiatrist.

Recommended Dosage:  One to two capsules per day (or, see above) in divided doses.  It is recommended that vitamin B-6 (pyridoxine) be taken with other members of the B complex family.  In addition, consider taking 1,500 mg of bromelain in divided doses.

Warnings Information:

  • For dietary supplement use only,
  • Consult your physician before taking this vitamin if you are taking levodopa (L-dopa),
  • Keep out of reach of children,
  • Do not exceed recommended dosage,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using, please inform your physician,
  • If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement,
  • If the effects of allergic reaction occurs, discontinue Vitamin B-6 (pyridoxine) supplements immediately.

Pricing Information:  Vitamin B6 (pyridoxine) supplements | Bromelain | Vitamin B12 methylcobalamin | Vitamin K1, K2 |
Vitamin C
| Vitamin E / Gamma E | Life Extension Mix


The American Academy of Nurse Practitioners annual meeting, Anaheim, CA, July 1, 2003.

Ellis, J.M. et al. "Response of Vitamin B6 deficiency and the carpal tunnel syndrome to pyridoxine." Proceedings of the National Academy of Science. 1982, 79:7494.

Ellis, J.M. "Free of Pain: Specific Types of Rheumatism." 1983. Southwest Publishing, Brownsville and Dallas, Texas.

Ellis, J.M. "Carpal tunnel syndrome and vitamin B6." Southern Medical Journal. 1987, 80:882.

Abraham, G.E., and Hargrove J. "Effect of vitamin B6 on premenstrual (PMS) symptomatology in women with premenstrual tension syndromes: A double-blind crossover study." Infertility. 1980, 3:155.

Kasden, M.L., and James, C.J. "Carpal tunnel syndrome and vitamin B6." Plastic and Reconstructive Surgery. 1987, 80:882.

Rinehart, J.F., and Greenberg, L.D. "Arteriosclerotic lesions in pyridoxine deficient monkeys." American Journal of Pathology. 1969, 25:481.

DiSorbo, D.M., and Nathanson, L. "High dose pyridoxal supplemented culture medium and the growth of a human malignant melanoma cell line." Nutrition and canc. 1983, 5(1):10.

DiSorbo, D.M., Wagner, R. Jr., and Nathanson, L. "In vivo and in vitro -- B16 melanoma growth and B6." Nutrition and canc. 1985, 7:43.

Baumblat, M.J., and Winston F. "Pyridoxine and the pill." Lancet. 1970, 1:832.

Adams, P.W. et al. "Influence of oral contraceptives, pyridoxine, and tryptophan on carbohydrate metabolism." Lancet. 1976, 1:759.

Schaumberg, H. et al. "Sensory neuropathy from pyridoxine abuse." New England Journal of Medicine. 1983, 309:445.


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