Vitamin C by Life Extension - Side Effects, Ester, Chlorine, Facts, Benefits, Deficiency, Ascorbic Acid

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Vitamin C by Life Extension
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Vitamin C Side Effects, Benefits, Deficiency, Ester, Facts, Ascorbic Acid

Note:  All of our Vitamin C products contain only pharmaceutical-grade ascorbic acid, buffers, or ascorbates.

More vitamin C is contained in the adrenal glands than any other organ in the body and is required at higher levels during times of stress.  Physical stress on the body such as ingestion of heavy metals, cigarette smoking, infections, extreme temperatures, and chronic use of certain medications such as aspirin also signal the need for increased intake of vitamin C.

Along with ascorbic acid, vitamin C also comes in at least two other forms:  Chemically bonded to minerals as ascorbates (referred by some as ester C - see Dr. Cathcart below), and as the fat-soluble ascorbyl palmitate.  Both of these forms are non-acidic.

Concerning Ester C
According to Robert Cathcart, MD, a physician with vast experience with high dose vitamin C protocols, mineral ascorbates (ester) are generally not as effective therapeutically as ascorbic acid:

"...it was not entirely clear that the dramatic effects are always with ascorbic acid orally and sodium ascorbate intravenously.  I have not been able to achieve the ascorbate effect with mineral ascorbates orally.  Mineral ascorbates are fine forms of vitamin C but the mitochondria are failing in their refueling of the free radical scavengers with electrons.  Ascorbic acid carries 2 extra electrons per molecule where the mineral ascorbates seem to carry only one (plus per molecule the mineral ascorbates are heavier due to the mineral weighing more than the hydrogen the mineral replaces).  So, the mineral ascorbates are not potent enough to accomplish the ascorbate effect.  There may be other reasons that we do not appreciate additionally."  Robert Cathcart, III, MD.


Vitamin C
The following reprinted by permission from Dusty R. Green, M.Ed., Research Scientist / Author of
Smart Eats, Smart Supplements, and Smart Exercise

The first clinical experiment with vitamin C dates back to the 1750's when a British doctor put limes, which for foodstuffs are rich in vitamin C, in the rations of a group of sailors.  He then compared this group to another group that received the same rations but without limes.  The lime-less group developed scurvy and its side effects (non-healing wounds, bleeding gums, rough skin, and muscle atrophy).  The lime group did not get scurvy and became known as "limeys" because they took limes with them on long voyages.

Robert Fulton Cathcart III, M.D., has more clinical experience with vitamin C than probably anyone else.  In the early 1970's after reading one of Dr. Linus Pauling's book, Dr. Cathcart decided to give up his practice as an orthopedic surgeon and become a general practitioner concerned with varying doses of vitamin C and its relationship to human health.  By 1981, he was able to report his observations on 9,000 patients he treated with vitamin C and its positive or negative side effects.

Like so many of the other vitamins, it is water soluble (your body stores it for a short period of time).  We can increase blood levels by taking it throughout the day, everyday.  Dr. Cathcart found that we all have a bowel tolerance limit of vitamin C (diarrhea side effects).  His patients who had very low blood levels of vitamin C (the severely ill) could tolerate more than 200 gms (not mgs) per day before the onset of diarrhea side effects.  As the patients' illnesses improved, the amount of vitamin C could be lowered because of the increased levels of it in the blood (serum level).  The amount would then be lowered toward the normal 3-15 gm. per day range.

Your bowel tolerance limit is a barometer of vitamin C intake.  Of course, water consumption (distilled or reverse osmosis ... such that you urinate every three hours) is highly recommended, even if you do not induce diarrhea side effects with vitamin C.  Soft drinks and coffee provide water but add calories, caffeine, sugar, and an acid ph.  Most foods have water content as do fruit juices but, because of the extra calories, do not rely on them to quench your thirst.

Vitamin C has been researched extensively concerning connective tissue strength (tendons, ligaments, arterial, and vein strength).  Vitamin C is crucial for the proper function of the enzyme protocollagen hydroxylase.  Protocollagen hydroxylase produces collagen, the primary constituent of the granulation tissue and the key component in blood vessel walls.  Vitamin C must be replenished daily since it is water-soluble, and any excess is excreted rather than stored.  The scientific literature is replete with information recommending Vitamin C in amounts of at least 3 grams per day (divided doses throughout the day are best) without side effects.  Less than 3 grams per day consumption does not show significant benefits according to most studies.

Life Extension Mix contains Vitamin C
Life Extension Mix contains the most diverse group of vitamin C compounds ever put into a multi-nutrient formula.  Four different forms of vitamin C are contained in Life Extension Mix, including three forms of water soluble vitamin C and the critically important fat soluble vitamin C compound, ascorbyl palmitate.

Pharmaceutical grade vitamin C and ascorbyl palmitate by Roche Laboratories are used in Life Extension Mix because of the extraordinary quality control Roche exercises in producing all its vitamin C products.  Roche engages in 18 different purification processes in producing vitamin C powders in order to remove all traces of toxic side-effects-laden by-products such as iron, cadmium and arsenic.  There are companies that fail to follow this kind of stringent purification protocol, selling vitamin C at far cheaper prices, but you'll never find this kind of substandard vitamin C in any product recommended by SmartBodyz Nutrition.


Note on So-called 'Natural' Vitamin C
by, The Vitamin C Foundation

There is no form of Vitamin C more "natural" than the molecule that virtually all species (except humans) manufacture in their livers or kidneys -- L-ascorbic acid.  This molecule in chemical notation is C6H8O6, and your body can't tell the difference between these molecules.

There are companies that market "natural" C-complexes to hide the fact that their vitamin C is less pure.  Unlike Vitamin E, the only difference between brands of vitamin C are impurities introduced during the manufacturing process.

Study the label of so-called 'natural' products.  If the product has more than 200 mg of vitamin C, we will bet it contains regular (manufactured) vitamin C as ascorbic acid.  If it contains less, remember you can get the same amount of vitamin C by eating a few oranges.


Note:  High-dose ascorbic acid may encourage intercourse frequency and improve moods: a randomized controlled clinical trial --  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12208645&dopt=Abstract

Caution:  Ascorbic acid is the acidic form of vitamin C, and even when encapsulated can cause side effects of gastric upset or diarrhea for some people when taken in large amounts (4 or more grams per day for most people).  This can often be alleviated by consuming it with meals.  Start with a low dose then gradually increase.  If you have a stomach ulcer, use of an antacid/buffering agent, mastic gum (highly recommended) or a buffered form of vitamin C should be considered.  Unbuffered ascorbic acid in the mouth may be harmful to tooth enamel.



Vitamin C Effectively Neutralizes Chlorine

From:  http://www.fs.fed.us/eng/php/library_card.php?p_num=0523%201301P by, Land, Brenda.  Using Vitamin C To Neutralize Chlorine in Water Systems.  0523 1301P.  San Dimas, CA: U.S. Department of Agriculture, Forest Service, San Dimas Technology and Development Center. 4 pgs, 2005.

Vitamin C effectively neutralizes chlorine and is safer to handle than sulfur-based dechlorination chemicals.  The sodium ascorbate form of vitamin C has less affect on pH than the ascorbic acid form.  When neutralizing a strong chlorine solution, both forms of vitamin C will lower slightly the dissolved oxygen of the treated water.  If passive dechlorination is not practical, we recommend some form of vitamin C.


Ascorbic Acid pH

Temperature (C)

Dissolved Oxygen (mg/L) Total Chlorine (mg/L) Free Chlorine (mg/L)
5 gal tap water 7.6 22.3 8.3 0.75 0.05
+ 15 % sodium chloride 8.0 21.7 9.7 66.6 47.8
+ 2.5gm ascorbic acid 6.2 21.1 5.7 0.00 0.02

Warnings Information:

  • For dietary supplement use only,

  • Keep Vitamin C supplements out of reach of children,

  • Do not exceed recommended dosage,

  • If you have a bad reaction or side effects, discontinue use immediately,

  • When using, please inform your physician.

Pricing Information:  Vitamin C | B Complex | Vitamin B12 methylcobalamin | Vitamin K1, K2 |
Vitamin E / Gamma E
| Life Extension Mix

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