Bone Assure - Calcium Mineral Supplement Level - Information / Use / Benefit / Absorption

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Bone Assure - Calcium Mineral Supplement Level - Information / Use / Benefit / Absorption
Reprinted by permission from William Faloon of the Life Extension Foundation

We apologize but Bone Assure has been replaced by Bone Restore or Bone Strength w/KoAct, however this is a great article that pertains to the new formulas.

Order:  Bone Restore and Bone Strength w/KoAct


CALCIUM -- Keep What You Take
By William Faloon

Today, there is overwhelming evidence that most women fail to consume the nutrients that are proven to support bone mass.  Now it's easy to follow a mineral supplement program that is scientifically substantiated to help maintain strong, healthy, bones and connective tissues.

A scientific consensus on the importance of adequate calcium intake has caused calcium preparations to become popular dietary supplements.  While consumers understand the critical need of maintaining healthy bones, few supplements provide the proper amount of calcium and other nutrients required to support the prevention of osteoporosis.

The sheer number of Americans affected by osteoporosis makes it a major health problem.  There are now 25 million Americans afflicted with osteoporosis.  Hip fractures will occur in nearly one-third of all women.  Bone fractures caused by loss of bone density compete with senility as the primary reason aged people are forced into nursing homes.

Are You Absorbing Your Supplemental Calcium?
There are several different forms of calcium available to consumers.  Each form has a different degree of solubility and absorption.  Young people produce high levels of stomach hydrochloric acid and can easily solubilize and absorb almost any form of calcium.  Older people, on the other hand, often have a stomach acid deficit or take drugs that block stomach acid production.  Those with insufficient stomach acid output have been shown to absorb only about 4% of calcium carbonate supplements, whereas these same people will absorb 45% of calcium citrate supplements.  Even people with normal levels of stomach acid only absorb about 22% of calcium carbonate supplements.  Most commercial calcium preparations found in pharmacies contain low-cost calcium carbonate, including OTC (over the counter) anti-acid products that claim to have a high calcium content.  Supplement companies often promote the benefits of oyster-shell calcium, but this form is really only calcium carbonate obtained from oyster shell.  Another form of calcium that has gotten a lot of recognition is calcium hydroxyapatite, which comes from purified bone meal.  One study showed that this expensive form of calcium has an absorption rate that is about 32% less than calcium carbonate.

Since the body needs between 1000 and 2000 mg of elemental calcium a day, the rate of mineral absorption into the bloodstream is a critical consideration.  The wrong form can result in a person swallowing a lot of pills and absorbing little actual calcium into their blood stream.  Calcium citrate is most often used by the informed consumer who understands the importance of getting calcium into the bloodstream where it is used to maintain and help re-mineralize bone.

While calcium citrate is superior to most commercial calcium supplements, there are two other forms of calcium that have shown better solubility and absorption.  When the chelating agent malic acid is added to calcium citrate, calcium citrate malate is created, a compound that is 10 times more soluble than calcium citrate.

"Solubility" refers to the amount of a mineral that can be dissolved in water at a neutral ph.  If stomach acid levels are high, most forms of calcium are soluble.  But, as people grow older, the need for a soluble form of calcium can become critical.  Based on human absorption studies, calcium citrate-malate is about 30% more absorbable than calcium citrate.  Calcium is first solubilized in the stomach, and then absorbed into the bloodstream through the intestine.  A highly alkaline intestine can interfere with calcium absorption, but vitamin D3 can increase intestinal absorption.

The most absorbable form of calcium is called calcium bis-glycinate.  This form of calcium is 205 times more soluble than calcium citrate.  In human studies, calcium bis-glycinate was shown to absorb 1.8 times better (180%) than calcium citrate and 21% better than calcium citrate-malate.

Conventional nutritional scientists have long looked at "solubility" as being critical for mineral absorption.  This assumption is being challenged by studies showing that other factors are involved in calcium absorption.  The fact that calcium bis-glycinate is 1.8 times better absorbed compared to calcium citrate, but that bis-glycinate is 205 times more soluble than citrate, clearly shows that solubility is only one determinant of how much calcium is actually absorbed into the blood.

Why Women Don't Get Enough Calcium
The body requires large amounts of calcium to maintain bone density.  The problem with commercial calcium preparations is that a lot of pills are required to be swallowed in order to get the recommended 1000 to 2000 mg of elemental calcium per day.  The greatest area of confusion is with the labeling.  A capsule that contains 1000 mg of calcium citrate provides only 220 mg of elemental calcium.  Some women mistakenly take just one or two capsules a day because the bottle may state "Calcium Citrate 1000 mg."  An examination of the label, however, will reveal that the amount of actual calcium per capsule is considerably less.

Even women who know they should be getting more supplemental calcium fail to do so because they don't want to swallow more pills.  That is why taking a highly absorbable calcium supplement is so important.  Based on human absorption studies, a woman taking 1000 mg of elemental calcium in the bis-glycinate form would be absorbing the equivalent 1820 mg of calcium if taken in the citrate form (calcium citrate).  When calcium is bound to glycine to form calcium bis-glycinate, it becomes an amino acid chelate that can be utilized by cells throughout the body.  Amino acid chelating agents promote the assimilation of the mineral into the cells to facilitate the Krebs energy cycle.  A fascinating human study on calcium absorption can be found in the journal Calcified Tissue International (1990, 46:300-304).

The recent availability of low-cost calcium bisglycinate enables people to get more calcium into their bloodstream while taking fewer capsules/tablets per day.

When calcium is in tablet form, it may not break down in the digestive tract unless it has passed the dissolution test.  The dissolution test shows tablets breaking apart in water in 30-45 minutes.

Bones Need More Than Just Calcium
While calcium by itself can aid in the prevention of some bone loss, there are other critical minerals that should be supplemented.  The hard mass characteristic of healthy bone is formed by inorganic minerals such as calcium, magnesium and phosphorous.  This hard part of the bone is sometimes referred to as the "mineral mass."  The structural framework that holds the "mineral mass" in place is called the "organic bone matrix."  The organic matrix is comprised of proteins that require adequate amounts of zinc, manganese and copper in order to properly function.  The trace minerals zinc, manganese and copper are essential co-factors for enzymes involved in the synthesis of the constituents that make up the bone matrix.

A group of scientists at the University of California San Diego began an investigation into the minerals needed for the organic bone framework after star basketball player Bill Walton developed multiple stress fractures in response to an unorthodox diet that provided very low levels of zinc, manganese and copper.  The scientists conducted a literature search, and found that animals lost bone density when placed on diets that were deficient in zinc, manganese or copper.  The findings of these animal studies demonstrated that:

  • Zinc deficiency causes a reduction in osteoblast activity along with impaired collagen and chondroitin synthesis.  Osteoblasts are bone forming cells.
  • Manganese deficiency inhibits the biosynthesis of mucopolysaccharides that are used for organic bone matrix formation.
  • Copper deficiency prevents the healthy cross-linking of elastin to collagen.
The scientists noted that mature bone matrix is a complex, highly mineralized tissue with a structural framework composed primarily of collagen along with other connective tissue cells.  The bone matrix is a living protein complex that provides the structure needed to hold calcium, magnesium and other minerals that give bone youthful strength and density.

The next step the University of California scientists undertook was a study on postmenopausal women with a mean calcium intake of 606 mg a day.  The results showed that those who consumed less than 606 mg a day of calcium have lower bone mineral densities compared to those whose calcium intake was above the mean.  These same studies showed that women with low blood levels of copper also have lower bone mineral density levels.

The final study was a two-year, placebo controlled trial on 225 postmenopausal women.  One group received calcium supplements only, the second group zinc, manganese and copper, the third group received calcium plus zinc, manganese and copper, while the fourth group received a placebo.  After two years, the only group who experienced an improvement in bone mineral density was the group taking calcium plus zinc, manganese and copper.  All the other groups (calcium only, zinc-manganese-copper only, and placebo) lost bone density.  The placebo group lost 2.23% of bone mineral density, while the calcium plus trace minerals gained 1.28%.  The calcium only group showed a 0.50% loss of bone mineral density.  The most significant difference was the large bone density reduction the placebo group compared to the increase in bone density in the group who received calcium plus zinc, manganese and copper.  This series of studies were first published in the American Journal of Clinical Nutrition (1993; Vol 12, No. 4, pp-384-389).

Magnesium may be as important as calcium.  Women with osteoporosis have lower bone magnesium levels than people with healthy bone mass.  One study involving 31 postmenopausal women found that magnesium supplementation by itself resulted in a slight improvement in bone density compared to the placebo group who showed a slight decrease in bone density.  Not only does magnesium contribute to bone mineral mass, but it is critical for the proper function of vitamin D.

Preventing Excessive Urinary Excretion of Calcium and Magnesium
A mineral that regulates estrogen and testosterone metabolism in postmenopausal women is boron.  Published studies consistently show that the administration of small amounts of boron (2-3 mg/day) reduce the amount of calcium and magnesium urinary excretion.  The effect of boron in preserving critical minerals is more apparent when dietary intake of magnesium is low.  In response to boron supplementation, estrogen and testosterone levels increase in postmenopausal women when magnesium intake is low.  The findings on boron indicate that 3 mg a day will help prevent excessive urinary loss of calcium and magnesium and thus reduce age-associated bone demineralization.

Active Vitamin D3 Has A Direct Anabolic Effect on Bone
Vitamin D is often combined with calcium supplements to enhance absorption of calcium into the bloodstream and improve the utilization of serum calcium into the bone matrix.  Some human studies show that vitamin D3 and calcium improve bone density, but that calcium by itself does not.  Vitamin D3 consistently shows its hormone-like properties by directing serum calcium to the bone and suppressing excess parathyroid hormone levels (that can pull calcium from the bone).

The active bone building metabolite of vitamin D3 is a hormone called calcitriol.  Those with severe osteoporosis are prescribed calcitriol in the form of a prescription drug, but for prevention and general treatment purposes, vitamin D3 itself provides calcitriol in a safer form than by taking the calcitriol drug.

In a meticulous study published in the journal Endocrinology (1998, Vol 139, No 10), the ovaries of female rats were removed for the purpose of inducing an estrogen and progesterone deficiency.  The effects of estrogen-progesterone ablation was a severe 90% reduction in tibial bone and a 43% reduction in vertebral bone.  This structural deterioration of bone was seen throughout the skeleton and provides an acute view of the catabolic effects of hormonal deprivation.  The scientists administered varying doses of calcium and/or active vitamin D3 to these hormone-deprived rats and measured the effects on bone density.  After three months, relative to the rats not given the supplements, there was a 22.5% average increase in bone mass in the rats receiving low-dose active vitamin D3 alone or with calcium, and a 36.5% average increase in bone mass in the group receiving high-dose active vitamin D3 alone or with calcium.  The results of this study showed that active vitamin D3 by itself produced a direct anabolic effect on bone that was not dependent on supplemental calcium.  The scientists concluded by cautiously recommending that human osteoporosis patients might benefit by taking higher doses of active vitamin D3 with only maintenance levels of calcium.

How Prevalent is Osteoporosis in Men?
Men experience substantially less overall bone loss than women, but there are some skeletal sites where men have a high rate of fractures.  Men suffer an accelerated loss of cortical (outer layer) bone density that starts at age 40 and then begin to lose vertebral bone mass starting after age 50.  About 25% of hip fractures occur in men.  A study published in Calcified Tissue International (1998, Vol 63, pp-197-201) showed that intestinal calcium absorption in men decreases progressively with advancing age and this impaired absorption is caused by a lack of vitamin D3 combined with inadequate dietary calcium intake.  There is a significant decrease in vertebral bone mass in aging men that directly correlates to blood levels of vitamin D3 and dietary calcium.  Scientists speculate that a vitamin D3 deficiency causes a slight increase in the release of parathyroid hormone (PTH) that results in calcium being pulled from the bone.  The effect of over-secretion of PTH is especially damaging to bone when dietary sources of calcium are low.

Bone loss patterns in men are different than women, but one study shows that men and women suffer equal loss of bone density to the spine.  This reduction in vertebral bone mass could explain why aged men and women develop spinal deformities that result in a humped-over-posture.

A review of the published literature indicates that healthy men approaching age 40 should take about two-thirds the amount of calcium as women.  So, if women are supposed to take six capsules a day of a bone-building calcium formula, men should take four capsules.  Men who undergo testosterone ablation therapy to treat the prostate are at a great risk for losing significant bone mass over a relatively brief period of time.  These men should take at least as much calcium as women.  Anyone taking chronic doses of corticosteroid drugs, drinking excess amounts of caffeine or alcohol, smoking cigarettes or not exercising may need extra calcium and other minerals required to maintain the protein (organic) structural bone framework and the inorganic (mineral) bone mass.

Minerals Support the Prevention of Cardiovascular Disease
Magnesium has been clearly established to aid in the protection against cardiovascular disease.  In a study published in the journal Epidemiology (1999; 10:4-6, pp331-36), researchers examined the levels of magnesium and calcium from 16 different municipalities in Sweden.  They then obtained information on all women in the study areas who died between the ages of 50 and 69 years from 1982 to 1993 and compared the causes of death to the different water supplies where the women lived.  The researchers concluded that higher levels of both calcium and magnesium in drinking water appeared to protect women's hearts.  For men, water calcium had no effect on heart attack, but for women, a low level of calcium appeared to be a risk factor.

Women have a higher need for calcium than men and Bone Assure reflects this need.  Since the body's calcium level drops during sleep, calcium containing formulas should be taken in the evening.  The form of calcium in Bone Assure has been shown to maintain bone density better than the standard forms of calcium used in commercial calcium supplements.

Commercial calcium supplements provide limited protection against the demineralization of bone that occurs with aging.  The scientific literature, on the other hand, documents a wide range of minerals that are vital to maintaining strong healthy bones.

For those who have already lost bone density, the proper combination of nutrients can help restore bone mass by rebuilding the organic matrix that holds minerals such as calcium and magnesium in place.

Bone Assure is a comprehensive formula that can help support the prevention of osteoporosis in 5 different ways:

  • Provides potent amounts of elemental magnesium and a highly absorbable form of calcium (bis-glycinate) that has been shown to assimilate 1.8 times better than calcium citrate, one of the best known forms of calcium.
  • Maintains the organic bone matrix with the minerals zinc, manganese, silica and copper that are required for the formation of collagen (along with Vitamin C) and other living connective tissues.  Manganese has been shown to specifically act as an anabolic catalyst in the development and maintenance of the organic bone matrix.
  • Facilitates the absorption of calcium into the blood stream by providing vitamin D3.  Once in the bloodstream, vitamin D3 then acts as a hormone to direct calcium into the bone matrix.
  • Prevents excessive urinary excretion of calcium and magnesium by providing the trace mineral boron.
  • Bone Assure lowers toxic homocysteine levels that have been shown to damage the organic bone matrix by providing small amounts of folic acid, vitamin B6, and TMG.

Bone Assure provides the best absorbing form of calcium in the world.  You can obtain this complete formula at a lower cost than commercial mineral preparations.  Commercial preparations typically contain inferior forms of calcium and do not contain all the nutrients that have been shown in the scientific literature to help prevent osteoporosis.  It comes in capsules that burst open within 5 minutes of ingestion.  Most commercial preparations take much longer to break down and/or pass through your system without ever breaking down.

According to Robert Barefoot, research scientist and expert on the subject of the effects of calcium on the human body, you could get enough calcium for your daily needs from two gallons of milk, 23 pounds of spinach plus 17 pounds of broccoli, approximately 23 pounds of cabbage.

Another important aspect of keeping adequate levels of minerals in your body is the alkaline PH influence.  As a result, calcium and/or mineral supplements may be better antacids than commercial antacids.  For the most part, commercial antacids use inferior form of calcium.  Most people are in an acid PH state which can expose them to various maladies.  Even slight pH variations -- that is, more acidity -- can result in imbalances such as candida, indigestion, allergies, and low immune function.

Also, Vitamins K, C, gelatin, and the ingredients in Nutri-Joint or Drinkables Joint Repair are essential components for supporting the bone and connective tissue matrix.

Editors Note:  Vitamin D has gotten a lot of press as the bone vitamin.  Bone maintenance requires many factors; among them, parathyroid hormone, estrogen, calcium and calcitonin (another thyroid hormone).  When all of these factors plus vitamin K are present in adequate amounts, the skeleton will be totally replaced every 8 to 10 years with good, dense bone.

Dosage and Use:  Suggested use for this product for men is:  4 capsules daily -- preferably 1 in the AM and 3 in the PM after your last meal.

Suggested use for this product for women is:  6 capsules daily -- preferably 1 in the AM, 1 in the afternoon and the last 4 in the PM after your last meal.

  • Check the calcium and mineral level of other supplements you may be using and also estimate the amount of calcium you may be receiving in your diet to determine how many of the above you need for absorption.
  • This product is most effectively utilized when taken in divided doses with low level fiber meals for best absorption.
  • Total calcium level intake of greater than 2000 mg elemental per day provides no added benefits.
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