L-lysine / BHT FAQs - Herpes/Cold Sores Support & References

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L-lysine / BHT FAQs - Herpes/Cold Sores Support & References
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L-Lysine / BHT
FAQs for Herpes
/Cold Sores Support and References

Below are a few questions/comments concerning the use of l-lysine / BHT answered by Tom who is a Research Scientist with The Life Extension Foundation.

Mike asks a question concerning cold sores:  Does the use of Arginine promote cold sores?  I have read articles which suggest that Arginine is used by the herpes/cold sores virus to multiply.  I would appreciate any information you may have on the subject.  I would like to use the Arginine prior to workouts.  Thanks!

Tom Answers:  If you have had herpes (and therefore still have the virus latent within you) then you are best to stay away from l-arginine.  However, BHT and l-lysine can do much to alleviate any herpes/cold sores outbreak. -- Tom

Doug asks:  Is it possible to become toxic on l-lysine or to be poisoned by using it too long?

Tom Answers:  No.  Any excess lysine will simply be metabolized, used as fuel, or excreted.

Judy asks:  I read in Sandy Shaw and Durk Pearson's book (Life Extension) that BHT (Butylated Hydroxytoluene) may be an anti-viral good for herpes simplex (cold sores) in combination with lysine.  I have used this successfully over the years but have read elsewhere that BHT should not be used as it can be harmful.  Is it a safe product to use periodically for a week or so?

Tom answers:  Unless you have a compromised liver or are taking it in large daily doses chronically (more than 1 gram), it is safe enough to take and appears to have some benefits for many things.  I am not taking it currently, but I did for many years.


References:
Flodin NW. The metabolic roles, pharmacology, and toxicology of l-lysine. J Am Coll Nutr 16(1): 7—21, 1997.

Griffith RS, Walsh DE, and Myrmel KH. Use of L-lysine therapy in frequently recurrent herpes/cold sores simplex infection. Treatment and prophylaxis. Dermatologica 175: 183—190, 1987.

McCune MA, Perry HO, Muller SA, et al. Support of recurrent herpes simplex infections with l-lysine monohydrochloride. Cutis 34: 366—373, 1984.

DiGiovanna JJ and Blank H. Use of l-lysine in frequently recurrent herpes simplex infection: treatment and prophylaxis. Arch Dermatol 120: 48—51, 1984.

Kritchevsky D, et al. Gallstone formation in hamsters: influence of specific amino acids. Nutr Rep Int 29: 117, 1984.

Lexzczynski DE, et al. Excess dietary lysine induces hypercholesterolemia in chickens. Experientia 38: 266—267, 1982.

Wehner M, Schrader T, Finocchiaro P, Failla S, Consiglio G. A chiral sensor for l-arginine and l-lysine. Org Lett. 2000 Mar 9;2(5):605-8. [MEDLINE record in process]

Algert SJ, Stubblefield NE, Grasse BJ, Shragg GP, Connor JD. Assessment of dietary intake of lysine and arginine in patients with herpes/cold sores simplex.  J Am Diet Assoc. 1987 Nov;87(11):1560-1.

Griffith RS, DeLong DC, Nelson JD. Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture.  Chemotherapy. 1981;27(3):209-13.

Griffith RS, Norins AL, Kagan C. A multicentered study of lysine therapy in herpes/cold sores simplex infection. Dermatologica. 1978;156(5):257-67.

 

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