D, L Phenylalanine (dlpa) Side Effects, Structure, Benefits - Dose

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D,L-Phenylalanine 100 VCaps 500mg by Life Extension
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D, L Phenylalanine (dlpa) Side Effects, Structure, Benefits - Dose

D,L-Phenylalanine Capsules
500 mg, 100 Vege Capsules

D-phenylalanine is unique among amino acids because the D-form (normally not found in life) has biological activity that is different from its L-stereoisomer.  D,L-phenylalanine is a 50/50 mixture of the two stereoisomers.

D, L-Phenylalanine is the precursor to another amino acid called tyrosine.  Phenylalanine is an essential amino acid, which can be converted to L-tyrosine by a complex biochemical process which takes place in the liver side effect free.  Tyrosine has the same benefits as D, L-Phenylalanine except for one factor -- eating chocolate and/or phenylalanine causes the release of beta phenylethylamine, a neuromodulator.  Tyrosine does not appear to be as active in this role as chocolate or phenylalanine.  With chocolate, however, you would have to consume mass quantities to reap the benefits.  And, eating mass quantities of chocolate can mean the side effects of unwanted calories.

D, L-Phenylalanine and tyrosine compete with other amino acids.  They have to be able to pass through the stomach and blood brain barrier without competition.

The consensus of experts recommend taking phenylalanine or tyrosine (not both) on an empty stomach 20 minutes before eating.  Nor, should we take them with other amino acids (there are a few in Life Extension Mix).  Most research scientists recommend starting with 500-1,000 mg in the morning.  Some people take another 500-1,000 mg in the afternoon for that extra boost.  Taking it too late in the day may have side effects of insomnia.  Some people build up to 2,000 mg in the morning and 2,000 mg in the afternoon.

There has to be significant amounts of vitamin B6 and vitamin C present in your blood stream in order for phenylalanine or tyrosine to work.  The ingestion of 150-200 mg of Vitamin B6 and 3,000-4,000 mg of vitamin C divided throughout the day does a great job ... not to mention other benefits.  There are 100 mg of vitamin B6 and 2,500 mg of vitamin C in the full menu of Life Extension Mix.

D, L-Phenylalanine or tyrosine works especially well with caffeine and encourages the hypothalamus in the brain to release CCK (cholecystokinin), a hormone responsible for signaling fullness.


Supplement Facts:  Serving Size - 1 cap.  Servings / Container 100

Amount / Serving


500 mg

Other ingredients:  magnesium stearate, gelatin, and water.

Dosage and Use:
  • Suggested dose is 500 to 1000 mg in the morning or afternoon,
  • More may be necessary for increasing the feeling of well-being,
  • These products are most effectively utilized when taken on an empty stomach and are virtually side effects free,
  • Consume at least 15-20 minutes prior to eating other supplements or food that contain other amino acids.  Most other aminos compete with D,L-Phenylalanine (DLPA) via the blood-brain barrier,
  • Adequate co-factors (vitamins B6 and C) should be taken along with DLPA.

Editors Note:  For those with substance abuse issues, a consideration is to use kudzu and d,l phenylalanine in association with l-glutamine for lessening the desire for alcohol and carbohydrates.  Lithium orotate also shows promise in this arena along with n-acetyl l-cysteine (NAC).  There seems to be a synergistic relationship with all of these combined compared to any one single nutrient alone.  In addition, activated charcoal/bentonite clay is the preferred choice for detoxification of toxic substances and other poisons that can build-up in our bodies.

Cautions:  canc patients, such as those with melanoma, should avoid taking L-phenylalanine and/or L-tyrosine.  The side effect insomnia may occur from over-stimulation if taken too close to bedtime.

D, L-Phenylalanine should not be confused with phenylpropanolamine (a form of amphetamine).  Phenylpropanolamine is an appetite suppressant used in several over-the-counter diet pills.  It causes the brain to use up nor-epinephrine without producing more.

Phenylalanine and tyrosine should be used with caution by those with hypertension, phenylketonuria (PKU, a rare genetic defect of the brain), or pre-existing pigmented melanoma, (a type of skin canc).  Nor, should they be used in combination with anti-depressant drugs.

  • Keep out of reach of children,
  • Do not exceed recommended dose,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using D, L Phenylalanine (dlpa), please inform your physician.

D,L Phenylalanine (DLPA ) Side Effects Page 2 | References

 Order:   D, L-Phenylalanine

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