L-Theanine May Enhance Chemotherapy and Reduce Side Effects
L-Theanine Protects Healthy
Dox-induced cardiac toxicity may be associated with high levels of lipid peroxidation (fats becoming rancid) creating free radicals. A study published in 1996 shows that l-theanine may reverse lipid peroxidation in cardiac tissue. In studies on rodents, complete reversal of lipid peroxidation was achieved with 100 mg/kg of theanine. One of the supplement's actions is to help reverse the loss of glutathione peroxidase, an enzyme that is depleted by the extra free radicals.
Doxorubicin suppresses the ability of canc to spread. When combined with theanine, it appears to work even better. The same researchers conducted a study on the suppression of liver metastases in mice with ovarian sarcoma. Metastases were fewer than with dox alone.
Theanine May Assist Chemotherapy
Researchers wanted to see if l-theanine would make the drug work. In the first experiment, about one-quarter of the standard dose of idarubicin was used. At this dose, the drug doesn't usually work nor cause toxicity. When combined with theanine, however, idarubicin appeared to work without toxicity. Tumor weight was reduced by 49% and the amount of drug in the tumors doubled. In the next experiment, theanine was added to the usual therapeutic dose. Theanine supported the effectiveness of the drug and significantly lessened the usual bone marrow suppression. Leukocyte loss was reduced from 57% to 37%.
How Does it Work?
Theanine is an amino acid which is structurally similar to glutamate. This may be the key to its success. It appears to be able to fool canc cells into letting it in -- but once inside this "Trojan horse" acts very differently. Glutamatic acid, or glutamate, is one of the components of glutathione, the detoxifier. Since it looks like glutamic acid, canc cells may be mistakenly using l-theanine to create glutathione. But the glutathione they create with theanine does not detoxify like natural glutathione. Instead, this theanine-based glutathione appears to block the ability of canc cells to detoxify.
Researchers working with ovarian canc have discovered that theanine lowers the amount of glutathione in canc cells. Without this raw material, canc cells can't run their detoxification system. They lose their ability to detoxify, and thus, doxorubicin may become more toxic to them. It is likely that up to twice as much doxorubicin stays in canc cells treated with theanine.
These findings on glutamate and this detoxification system in canc cells is very important because most research on drug resistance in canc cells has been focused on a different system altogether. By showing that a non-toxic, side effect free, dietary supplement can enhance the amount of a chemotherapeutic drug, while reducing it in healthy cells, Japanese researchers have made a great leap forward. Theanine may be an ideal partner for doxorubicin chemotherapy.
In addition to using theanine as an adjunct therapy and with melinoma being in the limelight of television commercials, you may want to consider the legal ramifications of the disease by following the above link.
Note: The human equivalent dose of theanine as a chemotherapy adjuvant with doxorubicin is 500 to 1,000 mg/day. Be aware that no human studies have been conducted.
Black Cumin (Nigella
The suggested dose for l-theanine for relaxation and enhancing dopamine levels is 200 mg (1 capsule). For those seeking help with high blood pressure and/or enhance sex drive, take one l-theanine capsule 2-3 times throughout the day. The same dose applies for the benefits of continuous mood enhancement, learning and PMS support, virtually side effects free.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent side effects or any disease.
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